Yıkmış, SeydiAksu, FilizSandıkçı Altunatmaz, SemaÇöl, Başak Gökçe2022-05-112022-05-1120212304-8158https://doi.org/10.3390/foods10081703https://hdl.handle.net/20.500.11776/5057In recent years, non-thermal technology has been used for the enrichment of ultrasound bioactive components. For this purpose, it was applied to tomato vinegar and modeled with response surface methodology (RSM) and artificial neural network (ANN). At the end of the RSM, cupric reducing antioxidant capacity (68.64%), 1,1-diphenyl-2-picrylhydrazyl (62.47%), total flavonoid content (2.44 mg CE/mL), total phenolic content (12.22 mg GAE/mL), total ascorbic acid content (2.53 mg/100 mL) and total lycopene (5.44 ?g/mL) were determined. The ANN model has higher prediction accuracy than RSM. The microstructure, microbiological properties, sensory analysis, ACE (angiotensin-converting-enzyme) inhibitor and antidiabetic effects of the ultrasound-treated tomato vinegar (UTV) (8.9 min and 74.5 amplitude), traditional tomato vinegar (TTV) and pasteurized tomato vinegar (PTV) samples were then evaluated. UTV was generally appreciated by the panelists. It was determined that the microbiological properties were affected by the ultrasound treatment. UTV was found to have more effective ACE inhibitor and antidiabetic properties than other vinegar samples. As a result, the bioactive components of tomato vinegar were enriched with ultrasound treatment and positive effects on health were determined. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.en10.3390/foods10081703info:eu-repo/semantics/openAccessAce inhibitorAntidiabeticArtificial neural networkResponse surface methodologyUltrasoundVinegarArticle108Q1WOS:0006892353000012-s2.0-85111646887Q1