Preparation of pH and temperature sensitive microspheres having magnetic properties and controlled drug delivery system

Doksoz, DermanTaşdelen, Betül2022-05-112022-05-112017978-1-5386-0440-3https://hdl.handle.net/20.500.11776/6164Scientific Meeting on Electric Electronics, Computer Science, Biomedical Engineerings (EBBT) -- APR 20-21, 2017 -- Istanbul Arel Univ, Istanbul, TURKEYIn this study, thermoresponsive hydrogel microspheres, namely, poly(N-isopropylacrylamide) (PNIPAAm) were prepared by using an inverse suspension polymerization technique. The radiation-induced modification of PNIPAAm microspheres with itaconic acid (IA) was applied for synthesizing pH and thermoresponsive PNIPAAm-co-poly(itaconic acid) microspheres (PNIPAAm-co-PIA). The PNIPAAM-co-PIA microspheres were simply immersed with iron (Fe2+, Fe3+) ions. In order to investigate drug release behavior of the prepared microspheres, 5-Fluorouracil as a model drug, namely, anti-cancer drug.trinfo:eu-repo/semantics/closedAccessN-isopropylacrylamideitaconic acidmagneticdrugdrugmicrospherePreparation of pH and temperature sensitive microspheres having magnetic properties and controlled drug delivery systemManyetik özelliklere sahip sicaklik ve pH'a duyarli mikrokörelerin sentezi ve ilaç salim davranişlarinin incelenmesi]Conference ObjectN/AWOS:0004136866000182-s2.0-85025465536