Behzatoğlu, KemalYıldız, PelinÖznur, MeltemBozkurt, Erol Rüştü2022-05-112022-05-1120122036-36052036-3613https://doi.org/10.4081/rt.2012.e45https://hdl.handle.net/20.500.11776/8469Abundant myxoid stroma rarely occurs in urothelial carcinomas, and may cause diagnostic challenges when cells with eosinophilic cytoplasm forming nests and cords in a myxoid background are seen, particularly in the absence of typical carcinomatous appearance. Microscopic examination of transurethral resection specimen of a 71-year-old male patient revealed non-cohesive oval or elongated tumor cells with eosinophilic cytoplasm arranged in cord-like filigree pattern in an abundant myxoid stroma. Immunohisto chemically the tumor was positive for cytokeratin 7, cytokeratin 20, and 34BE12. About 90 to 100% nuclear staining was observed with p63, p53, and Ki-67. A second neoplasm with a flat overlying urothelial epithelium and a complete inverted cellular growth pattern was also noted. The neoplasm exhibited less than 2% and 10% nuclear staining with Ki-67 and p53, respectively. Considering histological, histochemical, and immunohistochemical findings, a diagnosis of synchronous urothelial carcinoma with abundant myxoid stroma and inverted papilloma was made.en10.4081/rt.2012.e45info:eu-repo/semantics/openAccessurinary bladderurothelial carcinomatransitional cell carcinomamyxoidinverted papillomaArticle43145147N/AWOS:0002196633000112-s2.0-8486650719723087801Q4