Ulusoy, SeyhanAkalın, Ramadan BilginÇevikbaş, HalimeBerisha, AvniOral, AyhanBosgelmez-Tinaz, Gulgun2023-04-202023-04-2020221746-09131746-0921https://doi.org/10.2217/fmb-2021-0174https://hdl.handle.net/20.500.11776/10880Aim: To investigate the hypothesis that zeolites interfere with quorum-sensing (QS) systems of Chromobacterium violaceum and Pseudomonas aeruginosa by adsorbing N-acyl homoserine lactone (AHL) signal molecules. Methods: QS inhibition by zeolite 4A was investigated using an AHL-based bioreporter assay. The adsorption of the AHLs was evaluated by performing inductively coupled plasma-optical emission spectroscopy and confirmed by Monte Carlo and molecular dynamic simulations. Results: Zeolite 4A reduced the violacein production in C. violaceum by over 90% and the biofilm formation, elastase and pyocyanin production in P. aeruginosa by 87, 68 and 98%, respectively. Conclusion: Zeolite 4A disrupts the QS systems of C. violaceum and P. aeruginosa by means of adsorbing 3-oxo-C6-AHL and 3-oxo-C12-AHL signaling molecules and can be developed as a novel QS jammer to combat P. aeruginosa-related infections.en10.2217/fmb-2021-0174info:eu-repo/semantics/closedAccessBiofilmsModelingPseudomonas AeruginosaQuorum SensingQuorum Sensing InhibitorsBiofilm FormationEssential OilsGenesDerivativesAdsorptionExpressionVirulenceEnzymeSteelArticle1711861871Q3WOS:00080621510000135658574