Callioglu, NihalGul, Derya K.Arslan, Ilke O.Geyikoglu, IpekDemircivi, Erguel2024-10-292024-10-2920240379-52841658-3175https://doi.org/10.15537/smj.2024.45.8.20240404https://hdl.handle.net/20.500.11776/14550Objectives: To uncover the predictive value of systemic immune-inflammatory index (SII) and systemic inflammatory response index (SIRI) on early pregnancy loss. Methods: A total of 535 individuals were enrolled in this retrospective analysis. The early pregnancy losses (EPL) group included patients between 18-35 years old who experienced EPL. The control group comprised healthy pregnant women who gave birth at >= 37 weeks. Results: The EPL group had significantly lower plateletcrit (p=0.04), platelet distribution width (PDW, p<0.0001), and RDW (p<0.0001) and higher monocyte (p<0.0001) and SIRI (p<0.0001) values than the control group. The hemoglobin, white blood cells, platelet count, neutrophil count, lymphocyte count, mean platelet volume, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and SII values were not significantly different between the EPL and control groups (p>0.05). The cut-off value for the SIRI that offers the best sensitivity/specificity balance was 1.48 (sensitivity of 63%; specificity of 63%) in the receiver operating characteristics curve. Among the inflammatory parameters for predicting EPL, PDW had highest specificity (84%), and RDW had the highest sensitivity (80%). Conclusion: This study provides compelling evidence that various inflammatory pathways may significantly contribute to EPL pathogenesis. Moreover, our findings suggest that SIRI could be a more effective marker than NLR, PLR, MLR, and SII in predicting EPL in an ongoing pregnancy, thereby potentially revolutionizing early pregnancy loss diagnostics.en10.15537/smj.2024.45.8.20240404info:eu-repo/semantics/openAccessearly pregnancy losssystemic immune- inflammatory indexsystemic inflammatory response indexsystemic immune- inflammatory indexsystemic inflammatory response indexmean platelet volumeinflammatory biomarkersArticle458808813N/AWOS:0013020494000062-s2.0-8520010173439074885Q3