The effect of long-term systemic immunosuppressive drug use on druse formation: a new perspective to age-related macular degeneration

dc.authorid0000-0003-1537-2192
dc.authorscopusid50263136900
dc.authorscopusid56086888000
dc.authorwosidmercan, ridvan/W-3342-2017
dc.contributor.authorSever, Özkan
dc.contributor.authorMercan, Rıdvan
dc.date.accessioned2022-05-11T14:12:44Z
dc.date.available2022-05-11T14:12:44Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground/aim: To evaluate the effect of the long-term use of systemic immunosuppressive drugs on druse formation in patients aged over 50 years. Materials and methods: The current retrospective cohort study includes 420 eyes of 420 patients. 210 eyes of 210 patients who used immunosuppressive drugs (Group 1) at least for the last 5 years and 210 eyes of 210 control patients (Group 2) who did not use any drugs were compared. All patients were older than 50 years and selected among patients who were followed by rheumatology and ophthalmology clinic at a tertiary university hospital. All patients had complete ophthalmic examination, fundus photography and optical coherence tomography (OCT). The primary outcome of this study is the difference in macular and paramacular druse formation rates between two groups. Results: Small, intermediate, large, soft, and paramacular druse formation rates were significantly lower in Group 1 than those in Group 2 (P = 0.028, P = 0.001, P = 0.001, P = 0.001, and P = 0.001, respectively). Conclusion: Patients who used long-term systemic immunosuppressive drugs had significantly lower hard and soft druse formation rate than age and sex matched control subjects.
dc.identifier.doi10.3906/sag-2001-36
dc.identifier.endpage1969
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue8en_US
dc.identifier.pmid33128358
dc.identifier.scopus2-s2.0-85098800608
dc.identifier.scopusqualityQ3
dc.identifier.startpage1963
dc.identifier.urihttps://doi.org/10.3906/sag-2001-36
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5657
dc.identifier.volume50
dc.identifier.wosWOS:000600735500027
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSever, Özkan
dc.institutionauthorMercan, Rıdvan
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDruse
dc.subjectsystemic immunosuppression
dc.subjectinflammation
dc.subjectage-related macular degeneration
dc.subjectComplement Factor-H
dc.subjectBruchs Membrane
dc.subjectActivation
dc.subjectInflammation
dc.subjectIndividuals
dc.subjectMechanism
dc.subjectVariant
dc.subjectCommon
dc.titleThe effect of long-term systemic immunosuppressive drug use on druse formation: a new perspective to age-related macular degeneration
dc.typeArticle

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