The effect of long-term systemic immunosuppressive drug use on druse formation: a new perspective to age-related macular degeneration

Yükleniyor...
Küçük Resim

Tarih

2020

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Tubitak Scientific & Technical Research Council Turkey

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Background/aim: To evaluate the effect of the long-term use of systemic immunosuppressive drugs on druse formation in patients aged over 50 years. Materials and methods: The current retrospective cohort study includes 420 eyes of 420 patients. 210 eyes of 210 patients who used immunosuppressive drugs (Group 1) at least for the last 5 years and 210 eyes of 210 control patients (Group 2) who did not use any drugs were compared. All patients were older than 50 years and selected among patients who were followed by rheumatology and ophthalmology clinic at a tertiary university hospital. All patients had complete ophthalmic examination, fundus photography and optical coherence tomography (OCT). The primary outcome of this study is the difference in macular and paramacular druse formation rates between two groups. Results: Small, intermediate, large, soft, and paramacular druse formation rates were significantly lower in Group 1 than those in Group 2 (P = 0.028, P = 0.001, P = 0.001, P = 0.001, and P = 0.001, respectively). Conclusion: Patients who used long-term systemic immunosuppressive drugs had significantly lower hard and soft druse formation rate than age and sex matched control subjects.

Açıklama

Anahtar Kelimeler

Druse, systemic immunosuppression, inflammation, age-related macular degeneration, Complement Factor-H, Bruchs Membrane, Activation, Inflammation, Individuals, Mechanism, Variant, Common

Kaynak

Turkish Journal of Medical Sciences

WoS Q Değeri

Q4

Scopus Q Değeri

Q3

Cilt

50

Sayı

8

Künye