A preliminary study for evaluation of SARS-COV-2 RNA present on atherosclerotic plaques SARS-CoV-2 on the atherosclerotic plaques

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dc.contributor.authorDonbaloglu, Mehmet Okan
dc.contributor.authorGurkan, Selami
dc.contributor.authorGur, Ozcan
dc.contributor.authorUyar, Yavuz
dc.contributor.authorArtik, Yakup
dc.date.accessioned2024-10-29T17:59:41Z
dc.date.available2024-10-29T17:59:41Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractAim: The aim of this study is to investigate the presence of SARS-CoV-2 RNA genome in atherosclerotic plaques in patients with a history of COVID-19 who are scheduled for surgery due to peripheral artery disease. Material and Methods: Between the relevant dates, 40 patients with COVID-19 disease who were operated for peripheral artery disease in our clinic were included in the study. Of the 40 samples, 20 were aortic tissue and 20 were endothelial tissue. These tissues consist of samples taken from the patient at the Cardiovascular Surgery Department. The samples were transferred to the Microbiology laboratory and extracted by PCR procedure. Laboratory diagnosis with the kit was performed by multiplex RT-qPCR targeting SARS-CoV-2 ORF1ab and N genes in a real-time PCR device. Results: Eight out of 20 patients in the endothelial group were female and 12 were male. Ten out of 20 patients in the aortic group were female and 10 were male. All samples were found as negative by PCR for SARS-CoV-2 at two study groups (aortic and endothelial tissues). Discussion: This valuable study was conducted under limited resources and challenging pandemic conditions. We believe that this study will serve as a preliminary investigation shedding light on the effects of atherosclerotic plaques in patients with COVID-19 and PCR positivity in long-term and large-scale cases.
dc.identifier.doi10.4328/ACAM.21905
dc.identifier.endpage287
dc.identifier.issn2667-663X
dc.identifier.startpage283
dc.identifier.urihttps://doi.org/10.4328/ACAM.21905
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14810
dc.identifier.volume14
dc.identifier.wosWOS:001087343700015
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherBayrakol Medical Publisher
dc.relation.ispartofAnnals of Clinical and Analytical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAtherosclerotic Plaque
dc.subjectSARS-CoV-2
dc.subjectReal Time PCR
dc.subjectPeripheral Tissue
dc.subjectVascular Tissue
dc.titleA preliminary study for evaluation of SARS-COV-2 RNA present on atherosclerotic plaques SARS-CoV-2 on the atherosclerotic plaques
dc.typeArticle

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