Central nervous system metastatic epithelial ovarian cancer. Clinical parameters and prognostic factors: a multicenter study of Anatolian Society of Medical Oncology

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dc.authorid0000-0002-6236-9829
dc.authorid0000-0003-4533-0620
dc.authorid0000-0001-9081-2405
dc.authorid0000-0001-9081-2405
dc.authorid0000-0002-5609-9658
dc.authorwosidGumusay, Ozge/AAT-3435-2021
dc.authorwosidKaraağaç, Mustafa/AAQ-8875-2021
dc.authorwosidseber, selcuk e/H-3327-2017
dc.authorwosidseber, selcuk/T-9539-2019
dc.contributor.authorŞeber, Erdoğan Selçuk
dc.contributor.authorTürkmen, E.
dc.contributor.authorHarputoğlu, H.
dc.contributor.authorYeşil, H.
dc.contributor.authorArpacı, Erkan
dc.contributor.authorMenekşe, S.
dc.contributor.authorYetişyiğit, Tarkan
dc.date.accessioned2022-05-11T14:40:55Z
dc.date.available2022-05-11T14:40:55Z
dc.date.issued2017
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı
dc.description.abstractCentral nervous system (CNS) metastasis is a rare event in the course of late stage epithelial ovarian cancer (EOC); however its incidence is increasing in parallel with prolonged survival of patients. Objective: The authors assessed the clinical parameters and potential prognostic features in patients with CNS metastatic disease. Materials and Methods: Clinical data of the 33 patients from the participating centers were retrospectively collected and analyzed. Median age at the time of CNS metastasis was 57 years. Median time from the diagnosis of primiuy EOC until CNS metastatic disease was 22 months. Nearly half (45.5%) of the patients had single CNS metastatic lesions and all patients in the study group except two received radiotherapy as palliative treatment. Median overall survival (OS) from the time of CNS metastasis was 15 months (0-66). At univariate analysis only number of brain metastatic lesions (p = 0.001) and presence of extracranial disease (p = 0.004) were strongly associated with OS whereas multimodal treatment, size of metastatic lesions, platinum sensitivity, age, grade, and disease stage at presentation were not. Development of CNS metastasis carries a poor prognosis, however patients with single metastatic lesions and only intracranial metastatic disease can have prolonged survival after appropriate palliative management of their disease.
dc.identifier.doi10.12892/ejgo3465.2017
dc.identifier.endpage231
dc.identifier.issn0392-2936
dc.identifier.issue2en_US
dc.identifier.pmid29953785
dc.identifier.startpage227
dc.identifier.urihttps://doi.org/10.12892/ejgo3465.2017
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8976
dc.identifier.volume38
dc.identifier.wosWOS:000396649000012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorŞeber, Erdoğan Selçuk
dc.institutionauthorYetişyiğit, Tarkan
dc.language.isoen
dc.publisherCanada Inc
dc.relation.ispartofEuropean Journal of Gynaecological Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCentral nervous system epithelial ovarian cancer
dc.subjectMetastasis
dc.subjectPalliative management
dc.subjectBrain Metastases
dc.subjectCerebral Metastases
dc.subjectRadiation-Therapy
dc.subjectCarcinoma
dc.titleCentral nervous system metastatic epithelial ovarian cancer. Clinical parameters and prognostic factors: a multicenter study of Anatolian Society of Medical Oncology
dc.typeArticle

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