A new marker of coronary collateral flow in patients presenting with acute myocardial infarction

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dc.authoridAydin, Cihan/0000-0002-1401-5727
dc.authoridCELIKKOL, ALIYE/0000-0002-3799-4470
dc.contributor.authorDemirkiran, A.
dc.contributor.authorAydin, C.
dc.contributor.authorYilmaz, A.
dc.contributor.authorCelikkol, A.
dc.contributor.authorAlpsoy, S.
dc.contributor.authorDonbaloglu, O.
dc.contributor.authorTopcu, B.
dc.date.accessioned2024-10-29T18:00:20Z
dc.date.available2024-10-29T18:00:20Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractOBJECTIVE: Multimerin-2 is an adhesion substrate between pericytes and basal membranes during angiogenesis. The present study aimed to assess the relationship between serum Multimerin-2 and coronary collateral flow grade. PATIENTS AND METHODS: Between April 2022 and August 2022, 88 patients with subacute ST-elevation myocardial infarction were included in this study. The main inclusion criteria were patients who present 12-48 hours after symptom onset and aged between 18 and 90 years. The patients were divided into two groups according to the Rentrop classification: poor collateral group (Rentrop grade 0-1) and good collateral group (Rentrop grade 2-3). Biochemical and hematological parameters were measured before coronary angiography. RESULTS: Serum Multimerin-2 levels were found to be significantly different between the two groups, and levels were higher in the Rentrop 2-3 group than in the Rentrop 0-1 group (3,527.9 +/- 1,194.2 pg/ml and 946.7 +/- 249.1 pg/ml; p < 0.00). Receiver operating characteristic curve analysis indicated that the area under the curve was 0.918 ( p = 0.001), and the best cut-off value of 849 pg/ ml had a sensitivity of 90.1% and a specificity of 84.1% for predicting Rentrop grade 2- 3 coronary flow. The number of patients with low left ventricular ejection fraction ( LVEF) by echocardiography at 30 days was significantly higher in patients with poor collateralization. CONCLUSIONS: Multimerin-2 levels were found to be higher in patients with Rentrop grade 2-3 coronary flow than Rentrop grade 0-1 coronary flow after myocardial infarction. We detected a potential relationship between MMR-2 and good coronary collateral formation.
dc.identifier.endpage6263
dc.identifier.issn1128-3602
dc.identifier.issue13en_US
dc.identifier.pmid37458637
dc.identifier.startpage6256
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14980
dc.identifier.volume27
dc.identifier.wosWOS:001045159300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMultimerin-2
dc.subjectCoronary collateral flow grade
dc.subjectMyocardial infarction
dc.subjectRentrop classification
dc.titleA new marker of coronary collateral flow in patients presenting with acute myocardial infarction
dc.typeArticle

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