Mechanical Impedance of Rat Glabrous Skin and Its Relation With Skin Morphometry

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dc.authorid0000-0003-4119-617X
dc.authorwosidDEVECIOGLU, ISMAIL/H-4523-2018
dc.contributor.authorGok, Caglar
dc.contributor.authorDevecioğlu, İsmail
dc.contributor.authorGüçlü, Burak
dc.date.accessioned2022-05-11T14:03:02Z
dc.date.available2022-05-11T14:03:02Z
dc.date.issued2022
dc.departmentFakülteler, Çorlu Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.description.abstractThe mechanical impedance of intact and epidermis-peeled rat glabrous skin was studied at two sites (digit and sole) and at two frequencies (40 Hz and 250 Hz). The thicknesses of skin layers at the corresponding regions were measured histologically from intact- and peeled-skin samples in every subject. Compared to intact sole skin, digital rat skin has thicker layers and higher mechanical resistance, and it is less stiff. The resistance of the skin significantly decreased after epidermal peeling at both the digit and the sole. Furthermore, peeling caused the reactance to become positive due to inertial effects. As the frequency was increased from 40 to 250 Hz, the resistance and stiffness also increased for the intact skin, while the peeled skin showed less frictional (i.e., resistance) but more inertial (i.e., positive reactance) effects. We estimated the mechanical properties of epidermis and dermis with lumped-element models developed for both intact and peeled conditions. The models predicted that dermis has higher mass, lower stiffness, and lower resistance compared to epidermis, similar to the experimental impedance results obtained in the peeled condition which consisted mostly of dermis. The overall impedance was simulated more successfully at 40 Hz. When both frequencies are considered, the models produced consistent results for resistance in both conditions. The results imply that most of the model parameters should be frequency-dependent and suggest that mechanical properties of epidermis can be related to its thickness. These findings may help in designing artificial skin for neuroprosthetic limbs.
dc.description.sponsorshipBogazici University Research FundBogazici University [10XP1]; Society for Neuroscience Abstracts [224.13]
dc.description.sponsorshipThis study was supported by Bogazici University Research Fund (BAP No. 10XP1) granted to Professor Guclu. Preliminary results were previously published as an abstract (C. Gok and B. Guclu (2017) Effects of morphometric variables and epidermal peeling on the mechanical impedance of rat glabrous skin, Society for Neuroscience Abstracts, 43, Program No. 224.13). The authors report no conflicts of interest.
dc.identifier.doi10.1115/1.4052225
dc.identifier.issn0148-0731
dc.identifier.issn1528-8951
dc.identifier.issue2en_US
dc.identifier.pmid34423811
dc.identifier.urihttps://doi.org/10.1115/1.4052225
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4583
dc.identifier.volume144
dc.identifier.wosWOS:000732721400005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorDevecioğlu, İsmail
dc.language.isoen
dc.publisherAsme
dc.relation.ispartofJournal Of Biomechanical Engineering-Transactions Of The Asme
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectglabrous skin
dc.subjectrat
dc.subjectvibration
dc.subjectmechanical impedance
dc.subjectstratum corneum
dc.subjectviable epidermis
dc.subjectdermis
dc.subjectneuroprosthetics
dc.subjectIn-Vivo
dc.subjectMeissner Corpuscles
dc.subjectStratum-Corneum
dc.subjectTactile
dc.subjectBehavior
dc.subjectResponses
dc.subjectModels
dc.subjectBiomechanics
dc.subjectCompression
dc.subjectSensitivity
dc.titleMechanical Impedance of Rat Glabrous Skin and Its Relation With Skin Morphometry
dc.typeArticle

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