Association of selenoprotein W1 (rs3786777) polymorphism, maternal plasma selenoprotein W (SelW), and selenium levels in patients with pre-eclampsia

dc.authorid0000-0002-1192-6242
dc.authorid0000-0003-2420-8415
dc.authorwosidYILDIZ, Mustafa/P-9934-2015
dc.authorwosidCinemre, Hakan/AAD-7506-2021
dc.authorwosidTüten, Abdullah/E-2856-2019
dc.authorwosidBAHTİYAR, NURTEN/D-6468-2019
dc.contributor.authorCinemre, Fatma Behice Serinkan
dc.contributor.authorCinemre, Hakan
dc.contributor.authorErdoğan, Elif
dc.contributor.authorDilaveroğlu, Nilgün
dc.contributor.authorTüten, Abdullah
dc.contributor.authorKaya, Baris
dc.contributor.authorAydemir, Birsen
dc.contributor.authorKızıler, Ali Rıza
dc.date.accessioned2022-05-11T14:41:19Z
dc.date.available2022-05-11T14:41:19Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.description.abstractObjective: To investigate the role of selenoprotein W1 (SEPW1) single nucleotide polymorphism (SNP) in etiopathogenesis of pre-eclampsia (PE) and its association with maternal selenoprotein W (SelW) and selenium levels. Materials and methods: In this study, 98 pregnant women who were diagnosed with PE and 100 healthy pregnant controls were investigated. To identify the polymorphism of the SEPW1 gene (rs3786777), allele-specific polymerase chain reaction (ASPCR) analysis was used. Serum selenium levels and plasma SelW levels were measured by graphite-furnace atomic absorption spectrophotometry and by ELISA, respectively. Results: Maternal selenium levels (mu g/L) were 92.56 +/- 6.10 and 86.26 +/- 6.33 in pregnant women with and without PE, respectively (p > 0.05). On the other hand, SelW levels (ng/mL) were significantly lower in PE (72.08 +/- 8.10) compared to controls (89.29 +/- 6.99) (p < 0.01). The frequencies of the CC, CA, and AA genotypes were found to be 26%, 61%, and 13% in pregnant women with PE and 28%, 55%, and 17% in healthy pregnant controls. The distribution of the SEPW1 genotypes and alleles did not differ significantly among subjects with and without PE. In PE patients, SelW levels were lower in CC and CA genotypes compared to controls (p < 0.05 and p < 0.001). Conclusion: SEPW1 gene polymorphism did not seem to affect risk of PE in our population. However, SelW levels were low in some genotypes of the gene, suggesting that SelW might have played a role in the etiopathogenesis of PE.
dc.identifier.doi10.5414/TEX01542
dc.identifier.endpage67
dc.identifier.issn0946-2104
dc.identifier.issue2en_US
dc.identifier.startpage61
dc.identifier.urihttps://doi.org/10.5414/TEX01542
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9144
dc.identifier.volume36
dc.identifier.wosWOS:000461900500002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.institutionauthorKızıler, Ali Rıza
dc.language.isoen
dc.publisherDustri-Verlag Dr Karl Feistle
dc.relation.ispartofTrace Elements and Electrolytes
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectpre-eclampsia
dc.subjectSEPW1 gene polymorphism
dc.subjectselenium
dc.subjectselenoprotein-W
dc.subjectCell-Cycle Progression
dc.subjectAntiangiogenic Factors
dc.subjectLipid-Peroxidation
dc.subjectTrace-Elements
dc.subjectDisease
dc.subjectSerum
dc.subjectExpression
dc.subjectDepletion
dc.subjectCancer
dc.subjectSepw1
dc.titleAssociation of selenoprotein W1 (rs3786777) polymorphism, maternal plasma selenoprotein W (SelW), and selenium levels in patients with pre-eclampsia
dc.typeArticle

Dosyalar