Investigation of reduced glycopeptid susceptibility among methicillin resistant staphylococci

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dc.contributor.authorGüneş, Hayati
dc.contributor.authorÇetin, Emel Sesli
dc.contributor.authorKaya, Selcuk
dc.contributor.authorAridogan, Buket Cicioglu
dc.date.accessioned2022-05-11T14:42:10Z
dc.date.available2022-05-11T14:42:10Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractIncidence of vancomycin intermediate Staphylococcus aureus (VISA) and vancomycin hetero-intermediate Staphylococcus aureus (h-VISA) has been increasing in the world and our country. We aimed to determine whether there is any difference between the minimal inhibitory concentration (MIC) of glycopeptide antibiotics against meticillin susceptible and resistant staphylococci and investigate the prevalence of VISA and h-VISA among Staphylococcus aureus strains. 60 MRSA, MSSA, MRCNS and MSCNS isolated in our laboratory between April 2007-2008, were included in this study. Bacteria were inoculated onto a BHI agar supplemented with 6 mu g/ml vancomycin, strains which have shown growth on screen agar were evaluated for being VISA/hVISA by determining PAP-AUC ratio. Vancomycin and teicoplanin MIC values of the strains were determined by microdilution and E-test methods. Two of MRSA strains which grew on screen agar were excepted as suspicious VISA/h-VISA and they were confirmed as h-VISA by PAP-AUC method. Among all strains, methicillin resistant strains showed higher MIC values for glycopeptides than methicillin susceptible strains. We suggested that clinicians should be aware of h-VISA and VISA strains which are being increasingly reported in the world. More clinically supported multisentric studies must be performed in our country to clarify these prevalence rates and determine the clinical relevance of this resistance profile.
dc.description.sponsorshipScientific Research Unit of Suleyman Demirel UniversitySuleyman Demirel University [1669-TU-08]
dc.description.sponsorshipThis project was supported by the Scientific Research Project Unit of Suleyman Demirel University under project number 1669-TU-08.
dc.identifier.doi10.5897/AJMR11.1445
dc.identifier.endpage459
dc.identifier.issn1996-0808
dc.identifier.issue2en_US
dc.identifier.startpage453
dc.identifier.urihttps://doi.org/10.5897/AJMR11.1445
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9260
dc.identifier.volume6
dc.identifier.wosWOS:000303765800036
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorGüneş, Hayati
dc.language.isoen
dc.publisherAcademic Journals
dc.relation.ispartofAfrican Journal of Microbiology Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectStaphylococci
dc.subjectmeticillin resistance
dc.subjectglycopeptid susceptibility
dc.subjectvancomycin intermediate Staphylococcus aureus (VISA)
dc.subjectvancomycin hetero-intermediate Staphylococcus aureus (h-VISA)
dc.subjectAureus Heterogeneously Resistant
dc.subjectVancomycin
dc.subjectEpidemiology
dc.subjectEmergence
dc.subjectStrains
dc.titleInvestigation of reduced glycopeptid susceptibility among methicillin resistant staphylococci
dc.typeArticle

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