Role of Quercetin in Cadmium-Induced Oxidative Stress, Testicular Damage, and Apoptosis in Rats

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dc.authorwosidAktas, Cevat/D-8468-2011
dc.authorwosidyarali, Oguzhan/AAK-4187-2021
dc.contributor.authorKanter, Mehmet
dc.contributor.authorAktoz, Tevfik
dc.contributor.authorAktaş, Cevat
dc.contributor.authorÖzen, Aliz
dc.contributor.authorYarali, Oguzhan
dc.contributor.authorKanter, Betul
dc.date.accessioned2022-05-11T14:42:04Z
dc.date.available2022-05-11T14:42:04Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractOBJECTIVE: The aim of this study was to investigate the role of quercetin on cadmium-induced oxidative stress, testicular damage, and apoptosis in rat testes. STUDY DESIGN: The rats were randomly allotted into 1 of 3 experimental groups: control, cadmium-treated, and cadmium-treated with quercetin; each group con- tained 10 animals. Control animals received daily injec- tions of the saline vehicle alone. The cadmium-treated group was injected subcutaneously with cadmium chloride (CdCl2) dissolved in saline at a dose of 2 mL/kg/ day for 30 days, resulting in a dosage of 1 mg/kg cadmium. The rats in quercetin-treated groups were given quercetin (15 mg/kg body weight) once a day i.p., starting 2 days prior to the cadmium injection during the study period. All animals were sacrificed and testes tissues were removed for histopathological and biochemical (malondialdehyde [MDA], superoxide dismutase [SOD], glutathione peroxidase [GSH-Px], and serum testosterone levels) investigation. RESULTS: The mean seminiferous tubule diameter, Johnsen's mean testicular biopsy score values, biochemical parameters (MDA, SOD, GSH-Px, and serum testosterone levels), and amount of germ cell apoptosis were significantly decreased in the cadmium-treated groups as compared to the control group. Furthermore, the quercetin-treated animals showed improved histological and biochemical parameters in the cadmium-treated group. CONCLUSION: The present study showed that quercetin treatment protected testes against toxic effects of cadmium. We believe that further preclinical research into the utility of quercetin may indicate its usefulness as a potential treatment for spermatogenesis after testicular injury caused by cadmium-treated rats.
dc.identifier.endpage51
dc.identifier.issn0884-6812
dc.identifier.issue1en_US
dc.identifier.pmid27363066
dc.identifier.startpage45
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9196
dc.identifier.volume38
dc.identifier.wosWOS:000381062100007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorAktaş, Cevat
dc.language.isoen
dc.publisherSci Printers & Publ Inc
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject3,3 ',4 ',5,7-pentahydroxyflavone
dc.subjectantioxidants
dc.subjectapoptosis
dc.subjectcadmium
dc.subjectcadmium poisoning
dc.subjectoxygen radicals
dc.subjectquercetin
dc.subjectreactive oxygen species
dc.subjecttestes
dc.subjecttesticles
dc.subjecttestis
dc.subjecttestosterone
dc.subjectCumin Nigella-Sativa
dc.titleRole of Quercetin in Cadmium-Induced Oxidative Stress, Testicular Damage, and Apoptosis in Rats
dc.typeArticle

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