The effect of silymarin on hepatic regeneration after partial hepatectomy: is silymarin effective in hepatic regeneration?

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dc.authorid0000-0003-2716-6222
dc.authorid0000-0002-9121-536X
dc.authorid0000-0002-9121-536X
dc.authorid0000-0003-2006-9198
dc.authorid0000-0001-9111-2734
dc.authorwosidtokgöz, serhat/F-1573-2016
dc.authorwosidErol, Huseyin Serkan/Q-3962-2019
dc.authorwosidSözen, Selim/ABA-6337-2020
dc.authorwosidErol, Huseyin Serkan/B-5793-2016
dc.authorwosidCetinkunar, Suleyman/AFP-2813-2022
dc.contributor.authorÇetinkunar, Süleyman
dc.contributor.authorTokgöz, Serhat
dc.contributor.authorBilgin, Bülent Çağlar
dc.contributor.authorErdem, Hasan
dc.contributor.authorAktimur, Recep
dc.contributor.authorCan, Serpil
dc.contributor.authorPolat, Yılmaz
dc.contributor.authorSözen, Selim
dc.date.accessioned2022-05-11T14:39:53Z
dc.date.available2022-05-11T14:39:53Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractAim: Silymarin from Silybum marianum was found to reduce liver injury. The aim of the present study was to investigate the effects of silymarin on hepatic regeneration in partially hepatectomized rats. Methods: Thirty Wistar-Albino rats were divided into 3 groups of 10 animals as sham, control and experimental groups. In the sham group (n= 10) abdominal incision was closed after laparotomy. In the control group (n= 10), the rats underwent 70% hepatectomy after laparotomy. In the experimental group (n= 10) after partial 70% hepatectomy, silymarin (200 mg/kg/d) were given to rats for 10 days. Rats in three groups were sacrificed on 10 days. Aspartate (AST) and alanine transaminase (ALT), gamma glutamyl transferase (GGT), ALP, LDH and total bilirubin levels were measured using intracardiac blood samples. Tissue malondialdehyde (MDA) and tissue glutathion (GSH) and Superoxide dismutase (SOD) levels were measured. To reveal the increase in the mass of the remnant liver tissue in the control and experimental groups relative weight of the liver was calculated. Histopathological analysis of the liver was performed using a semi-quantitative scoring system. Results: A statistically significant difference among three groups was not shown for AST and ALT levels. A statistically significant difference was found between the groups as for total bilirubin and gamma glutamyl transferase levels. Increases in relative liver weights were seen with time in Groups 2 and 3. A statistically significant difference was not found for tissue malondialdehyde, Glutathion and Superoxide dismutase levels between hepatectomy and hepatectomy + silymarin groups. On liver tissue sections of the rats in the hepatectomy + silymarin group, increased regeneration and lipid peroxidation were observed accompanied by decreased antioxidant response. Conclusion: It has been observed that silymarin with many established functions such as antiproliferative, anti-inflammatory and energy antioxidant effects, does not contributed to proliferative regeneration of the liver-which has very important metabolic functions -after partial hepatectomy; instead it will decrease serum levels of transaminases.
dc.identifier.endpage2585
dc.identifier.issn1940-5901
dc.identifier.issue2en_US
dc.identifier.pmid25932204
dc.identifier.startpage2578
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8782
dc.identifier.volume8
dc.identifier.wosWOS:000355306000120
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorSözen, Selim
dc.language.isoen
dc.publisherE-Century Publishing Corp
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSilymarin
dc.subjecthepatic regeneration
dc.subjecthepatectomy
dc.subjectLiver-Regeneration
dc.subjectRat-Liver
dc.subjectLipid-Peroxidation
dc.subjectOxidative Stress
dc.subjectInjury
dc.subjectSilibinin
dc.subjectDiseases
dc.subjectSize
dc.titleThe effect of silymarin on hepatic regeneration after partial hepatectomy: is silymarin effective in hepatic regeneration?
dc.typeArticle

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