Is it possible to predict morbidities in neonates born to mothers with immune thrombocytopenic purpura?: A retrospective cross-sectional study

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dc.authoridAslan, Mustafa Torehan/0000-0002-3966-4635
dc.contributor.authorAslan, Mustafa Torehan
dc.contributor.authorInce, Zeynep
dc.contributor.authorBilgin, Leyla
dc.contributor.authorIsguder, Cigdem Kunt
dc.contributor.authorCoban, Asuman
dc.date.accessioned2024-10-29T17:58:40Z
dc.date.available2024-10-29T17:58:40Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractImmune thrombocytopenic purpura (ITP) comprises similar to 1% to 4% of thrombocytopenia cases during pregnancy. Factors predicting neonatal thrombocytopenia and associated morbidities due to maternal ITP are unclear. The present study aimed to assess the neonatal outcomes of pregnant women with ITP. Fifty-five pregnant women with ITP and their babies, born between January/2013 and April/2021, were retrospectively reviewed. Maternal and neonatal thrombocytopenia cases other than ITP were excluded from the study. Physical examination, blood count, and cranial/abdominal ultrasonography findings of the newborns were recorded. Neonatal thrombocytopenia was defined as a platelet count < 150 x 10(9)/L. Relationship between neonatal thrombocytopenia and maternal factors was investigated. Thrombocytopenia was detected in 17/55 babies (30.9%), and 8/17 (47.1%) had symptoms of bleeding, all but one being mild bleeding. There was a significant correlation between neonatal platelet counts of < 100 x 10(9)/L and maternal splenectomy history. Incidence of moderate and severe thrombocytopenia was higher (statistically insignificant) in neonates of mothers with ITP. No significant correlation was determined between maternal and neonatal platelet counts. There was a weak insignificant correlation between platelet counts of neonates of mothers with or without thrombocytopenia. A significant correlation was found between the presence of splenectomy before delivery in the mother and a platelet count of < 100 x 10(9)/L in the neonate. Moderate and severe thrombocytopenia was higher in neonates of mothers diagnosed with ITP before pregnancy and needed treatment during pregnancy and/or delivery, but the difference was insignificant. Close follow-up of babies born to mothers with ITP after birth is crucial since there is no significant prediction criterion for developing neonatal thrombocytopenia and associated morbidities.
dc.identifier.doi10.1097/MD.0000000000038587
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.issue25en_US
dc.identifier.pmid38905433
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000038587
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14444
dc.identifier.volume103
dc.identifier.wosWOS:001252260600064
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofMedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcorticosteroid
dc.subjectimmune thrombocytopenic purpura
dc.subjectintravenous immunoglobulin
dc.subjectneonatal thrombocytopenia
dc.titleIs it possible to predict morbidities in neonates born to mothers with immune thrombocytopenic purpura?: A retrospective cross-sectional study
dc.typeArticle

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