Relationship between Microfibrillar-Associated Protein 4 Levels and Subclinical Myocardial Damage in Chronic Kidney Disease

Basit Öğe Kaydı
dc.authorid0000-0002-5923-953X
dc.authorwosidYilmaz, Ahsen/ABB-1083-2021
dc.contributor.authorKara, Sonat Pınar
dc.contributor.authorÖzkan, Gülsüm
dc.contributor.authorÖzkaramanlı Gür, Demet
dc.contributor.authorEmeksiz, Gaye Kübra
dc.contributor.authorYılmaz, Ahsen
dc.contributor.authorBayrakçı, Nergiz
dc.contributor.authorGüzel, Savaş
dc.date.accessioned2022-05-11T14:02:44Z
dc.date.available2022-05-11T14:02:44Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractIntroduction:Chronic kidney disease (CKD) is a widespread health problem, in which mortality is most frequently due to cardiovascular diseases. Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix protein. MFAP4 is involved in several biological processes, particularly the maintenance of vascular integrity and extracellular matrix remodeling. Our review of the literature revealed no data concerning MFAP4 levels in CKD and its relationship with myocardial functions.Objective:The purpose of this study was therefore to investigate MFAP4 levels in CKD, parameters affecting these, and the relationship with myocardial functions.Materials and Methods:Seventy-nine CKD patients and 30 healthy controls were included in the study. Routine biochemical tests and echocardiography were performed once demographic data had been recorded. Blood specimens were collected for MFAP4 analysis, and the results were subjected to statistical analysis.Results:MFAP4 levels were significantly higher in the patient group than in the control group (p< 0.001). Doppler parameters revealed more frequent LV diastolic impairment in the patient group. Tissue Doppler systolic velocity and global longitudinal strain were significantly impaired, revealing the subclinical LV systolic dysfunction in CKD patients. MFAP4 elevation in the patient group was positively correlated with aortic root (AR), global circumferential strain (GCS), and GCS rate.Conclusion:Our results showed MFAP4 elevation in CKD for the first time in the literature, and that this elevation may be related to GCS and AR dilation. We think that, once supported by further studies, MFAP4 may constitute a marker in the evaluation of myocardial functions in CKD.
dc.identifier.doi10.1159/000506827
dc.identifier.endpage265
dc.identifier.issn1664-3828
dc.identifier.issn1664-5502
dc.identifier.issue4en_US
dc.identifier.pmid32268335
dc.identifier.startpage257
dc.identifier.urihttps://doi.org/10.1159/000506827
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4457
dc.identifier.volume10
dc.identifier.wosWOS:000546455800006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorKara, Sonat Pınar
dc.institutionauthorÖzkan, Gülsüm
dc.institutionauthorÖzkaramanlı Gür, Demet
dc.institutionauthorEmeksiz, Gaye Kübra
dc.institutionauthorYılmaz, Ahsen
dc.institutionauthorBayrakçı, Nergiz
dc.institutionauthorGüzel, Savaş
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofCardiorenal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChronic kidney disease
dc.subjectChronic renal failure
dc.subjectMicrofibrillar-associated protein 4
dc.subjectMFAP4
dc.subjectMyocardial functions
dc.subjectEuropean Association
dc.subjectAmerican Society
dc.subjectEchocardiography
dc.subjectRecommendations
dc.subjectUpdate
dc.titleRelationship between Microfibrillar-Associated Protein 4 Levels and Subclinical Myocardial Damage in Chronic Kidney Disease
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
4457.pdf
Boyut:
378.25 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Tıp Fakültesi Koleksiyonu