Clinicopathological roles of Vasobin-2 in colorectal cancers
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bayrakol Medical Publisher
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Vasohibin-2(VASH2) is a pro-angiogenic molecule synthesized from mononuclear cells. The biological characteristics of colorectal cancer (CRC) cells and their microenvironment are not known yet. In the present study, the purpose was to investigate the clinicopathological roles of VASH2 in colorectal cancers. Material and Methods: Three-micron sections were made for Immunohistochemistry (IHC) Analysis of the paraffin block tissues of 159 patients who underwent curative surgery for CRC. Immunohistochemical staining was performed with anti-CD34 and anti-D2-40' and anti-Vasohibin-2 antibodies as lymphatic vessel markers on vascular endothelial cells. The density of newly formed vessels in the peripheral stroma of the tumor with CD34 and D240 and the presence of VASH-2 were investigated in these vessels. Results: It was determined in the relationship analysis of the variables that VASH2 positivity showed a positive relationship with tumor diameter (p<0.05). No significant relationships were detected with other prognostic factors. Advanced age, perineural invasion (PNI), and pathological stage were the parameters that predicted survival in the Cox Regression Analysis, in which many variables were included (p<0.05), and VASH2 positivity showed negative predictive characteristics together with CD 34 positivity (p<0.05). No relationship was detected between VASH2 expression levels and CD34 and D-240 in cancer stroma and paracancerous tissue. VASH2 expression was significantly lower in cancer stroma and VASH2, CD34, and D-240 levels were higher in paracancerous tissue; however, no relationship was detected in this respect. Discussion: In the present study, a significant relationship was detected between VASH2 and tumor diameter. However, no statistically significant differences associated with prognosis were detected. Further studies of its other roles in the tumor microenvironment as well as the pro-angiogenic characteristics of VASH2 will help to reveal the effects of this molecule in cancer angiogenesis.
Açıklama
Anahtar Kelimeler
Angiogenesis Stimulating Agents, Endothelial Cells, Immunohistochemistry, Vasohibin
Kaynak
Annals of Clinical and Analytical Medicine
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
14
Sayı
11
