Prognostic Value of Renal Dysfunction Indicators in Normotensive Patients With Acute Pulmonary Embolism

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dc.authorid0000-0002-5014-4972
dc.authorid0000-0001-6779-9070
dc.authorid0000-0002-2481-0978
dc.authorwosidOz, Ibrahim Ilker/AAM-4318-2020
dc.authorwosidAltinsoy, Bulent/A-9666-2017
dc.contributor.authorAltinsoy, Buelent
dc.contributor.authorÖz, İbrahim İlker
dc.contributor.authorÖrnek, Tacettin
dc.contributor.authorErboy, Fatma
dc.contributor.authorTanriverdi, Hakan
dc.contributor.authorUygur, Firat
dc.contributor.authorTor, Müge Meltem
dc.contributor.authorAltıntaş, Nejat
dc.date.accessioned2022-05-11T14:39:48Z
dc.date.available2022-05-11T14:39:48Z
dc.date.issued2017
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.description.abstractIntroduction: Glomerular filtration rate (GFR) and blood urea nitrogen (BUN) are important prognostic indicators for cardiovascular disease. However, data on the relationship between renal dysfunction (RD) and prognosis in patients with acute pulmonary embolism (APE) are limited. The estimated-GFR (eGFR), based on the Modification of Diet in Renal Disease (MDRD) equation, has been suggested as a possible prognostic marker in patients with APE; however, at present, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation is thought to be more accurate than the MDRD equation for the estimation of RD. Objective: We investigated whether eGFR(CKD-EPI) or BUN could predict adverse outcomes (AOs) better than eGFR(MDRD) in normotensive patients with APE. Methods: Ninety-nine normotensive patients with APE (aged 22-96, 56% male) were enrolled in the study retrospectively. Adverse outcomes were defined as the occurrence of any of the following: death, cardiopulmonary resuscitation, use of vasopressors, thrombolysis, or mechanical ventilation. Results: In univariate analyses, age, gender (male), heart rate (>110 bpm), serum creatinine, BUN, cardiac troponin (cTn) positivity, right ventricle-left ventricle ratio, eGFR(MDRD), and eGFR(CKD-EPI) were found to be significantly different between those with and without AOs. Comparing area under the curves for AO, we found statistically significant differences between eGFR(CKD-EPI) and eGFR(MDRD) (P = .01) but not between BUN and eGFR(CKD-EPI) or BUN and eGFR(MDRD). Furthermore, 30-day mortality was 36% versus 11% in cTn-positive patients with an eGFR(CKD-EPI) < and 60 mL/min, respectively. Conclusion: There is a close relationship between RD and APE prognosis. We conclude eGFR(CKD-EPI) is a potential prognostic marker for risk stratification in normotensive patients with APE.
dc.identifier.doi10.1177/1076029616637440
dc.identifier.endpage561
dc.identifier.issn1076-0296
dc.identifier.issn1938-2723
dc.identifier.issue6en_US
dc.identifier.pmid27013086
dc.identifier.startpage554
dc.identifier.urihttps://doi.org/10.1177/1076029616637440
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8728
dc.identifier.volume23
dc.identifier.wosWOS:000407813600006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorAltıntaş, Nejat
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofClinical and Applied Thrombosis-Hemostasis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectpulmonary embolism
dc.subjectrenal failure
dc.subjecturemia
dc.subjectChronic Kidney-Disease
dc.subjectCkd-Epi
dc.subjectBroad-Spectrum
dc.subjectCystatin C
dc.subjectRisk
dc.subjectPrevalence
dc.subjectMortality
dc.subjectEquation
dc.subjectAdmission
dc.subjectBiomarker
dc.titlePrognostic Value of Renal Dysfunction Indicators in Normotensive Patients With Acute Pulmonary Embolism
dc.typeArticle

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