Is Tc-99m-MDP whole body bone scintigraphy adjuvant to F-18-FDG-PET for the detection of skeletal metastases?

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dc.authorid0000-0002-3650-8258
dc.authorwosidELBOGA, UMUT/AAH-1320-2020
dc.authorwosidAKCAN, ABDULLAH BARIS/Q-3855-2019
dc.authorwosidSahin, Ertan/AAG-8999-2020
dc.contributor.authorŞahin, Ertan
dc.contributor.authorZincirkeser, Sabri
dc.contributor.authorAkcan, Abdullah Barış
dc.contributor.authorElboğa, Umut
dc.date.accessioned2022-05-11T14:40:53Z
dc.date.available2022-05-11T14:40:53Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nükleer Tıp Ana Bilim Dalı
dc.description.abstractPurpose: Due to the fact that fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG-PET/CT) and technetium-99m-methylenediphosphonate (Tc-99m-MDP) whole body scans identify bone metastases by different mechanisms, i.e. by using glucose metabolism and osteoblastic response in the bone, respectively, it can be expected that there may be some differences between these two methods in the number of lesions identified. The aim of this study was to compare the sensitivity,specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) in detecting bone metastases between F-18-FDG-PET/CT and conventional Tc-99m-MDP whole body scans. Methods: Between 2006-2009, 121 patients with malignancies (62 male and 59 female, mean age 59.3 +/- 10.8 years, range 37-84) were examined with F-18-FDG-PET/CT and conventional Tc-99-.MDP whole-body scans for detection of bone metastases. Results: For F-18-FDG-PET/CT and for (TC)-T-99m-MDP, sensitivity, specificity, accuracy, PPV and NPV for detecting all studied bone metastases were 88.3, 83.6, 86.7, 91.7, 77.8% and 91.7, 71.0, 84.9, 86.6, 80.8%, respectively. For bone metastases of breast and lung cancers, the specificity and accuracy of PET/CT was higher than that of bone scintigraphy. On the other hand, the sensitivity of bone scintigraphy was higher than PET/CT in breast and lung cancers groups and all patients. In the detection of osteolytic and osteosclerotic metastases no difference was found between the two methods, while for osteolytic lesions the mean standardized uptake value (SLIV) max was higher than for osteosclerotic lesions. Conclusion: For the detection of bone metastases the spesificity and accuracy of F-18-FDG-PET/CT were higher compared to bone scintigraphy, while the sensivity was lower. It is the opinion of the authors that both studies are complementary to final diagnosis.
dc.identifier.endpage296
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue1en_US
dc.identifier.pmid24659678
dc.identifier.startpage291
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8946
dc.identifier.volume19
dc.identifier.wosWOS:000334153000043
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorŞahin, Ertan
dc.language.isoen
dc.publisherImprimatur Publications
dc.relation.ispartofJournal of Buon
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbone metastases
dc.subjectbone scintigraphy
dc.subjectFDG-PET
dc.subjectTc-99m-MDP
dc.subjectPositron-Emission-Tomography
dc.subjectFdg-Pet
dc.subjectBreast-Cancer
dc.subjectScan
dc.subjectDiagnosis
dc.titleIs Tc-99m-MDP whole body bone scintigraphy adjuvant to F-18-FDG-PET for the detection of skeletal metastases?
dc.typeArticle

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