Purine Catabolic Enzymes and Nitric Oxide in Patients with Iron Deficiency Anemia

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dc.authorid0000-0002-2270-2965
dc.authorwosidYilmaz, Ahsen/ABB-1083-2021
dc.authorwosidAvcı, Okan/ABG-8782-2021
dc.contributor.authorOran, Mustafa
dc.contributor.authorAydın, Murat
dc.contributor.authorMete, Rafet
dc.contributor.authorTülübaş, Feti
dc.contributor.authorAvcı, Okan
dc.contributor.authorYılmaz, Ahsen
dc.contributor.authorGürel, Ahmet
dc.date.accessioned2022-05-11T14:14:03Z
dc.date.available2022-05-11T14:14:03Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractIntroduction: To clarify the mechanism of oxidative damage,which affects many tissues and organ systems in iron deficiency anemia, comes into prominence in the treatment and avoiding the complications of the disease. In the present study, serum uric acid, ADA, XO, and nitric oxide (NO) levels were measured in patients with iron deficiency anemia and healthy controls in order to ascertain the function of the above parameters in oxidative stress metabolism. Materials and method: A total of 36 patients (27 female and 9 male with a mean age of 31.1 +/- 6.9 years) with iron deficiency anemia and 36 healty controls (29 female and 7 male with a mean age of 29.8 +/- 7.7 years) were included in the study. The patients blood parameters, serum iron level, total iron binding capacity and ferritin levels were determined by using commercial kits.Serum adenosine deaminase, xanthine oxidase and nitric oxide measurements were performed spectrophotometrically with manual methods. Results: The levels of xanthine oxidase and uric acid in patients with iron deficiency anemia were found to be significantly lower than healthy controls (p=0.01 and 0.003, respectively), while nitric oxide levels were found to be significantly higher (p = 0.003). Adenosine deaminase levels in patients with iron deficiency anemia were significantly lower than in healthy controls, but the difference was not statistically significant. Discussion: It is known that, oxidative stress increases in iron deficiency anemia due to both increased oxidant molecules and the inadequate capacity of the antioxidant enzyme systems. Decreased levels of xanthine oxidase and uric acid and increased nitric oxide in patients with iron deficiency anemia compared to healthy population is considered to be a result of increased oxidative stress.
dc.identifier.endpage283
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue1en_US
dc.identifier.startpage279
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5761
dc.identifier.volume30
dc.identifier.wosWOS:000335937700046
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.institutionauthorOran, Mustafa
dc.institutionauthorAydın, Murat
dc.institutionauthorMete, Rafet
dc.institutionauthorTülübaş, Feti
dc.institutionauthorAvcı, Okan
dc.institutionauthorYılmaz, Ahsen
dc.institutionauthorGürel, Ahmet
dc.language.isoen
dc.publisherCarbone Editore
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIron deficiency anemia
dc.subjectAdenosine deaminase
dc.subjectXanthine oxidase
dc.subjectUric acid
dc.subjectNitric oxide
dc.subjectUric-Acid
dc.subjectOxidative Stress
dc.subjectGlutathione-Peroxidase
dc.subjectSuperoxide-Dismutase
dc.subjectLipid-Peroxidation
dc.subjectXanthine-Oxidase
dc.subjectSerum Ferritin
dc.subjectChildren
dc.subjectHypoxia
dc.subjectDisease
dc.titlePurine Catabolic Enzymes and Nitric Oxide in Patients with Iron Deficiency Anemia
dc.typeArticle

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