Endothelial dysfunction in children with low birth weight, born at term

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dc.authorid0000-0002-4060-0583
dc.authorid0000-0001-5992-9488
dc.authorwosidDonma, Metin/AAB-6079-2020
dc.authorwosidDonma, Mustafa Metin/ABF-2169-2021
dc.authorwosidDonma, Orkide/AAI-1853-2019
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorAkkoyun, Dursun Çayan
dc.contributor.authorNalbanto?lu, Burçin
dc.contributor.authorTopçu, Birol
dc.contributor.authorTülübaş, Feti
dc.contributor.authorDonma, Mustafa Metin
dc.date.accessioned2022-05-11T14:09:55Z
dc.date.available2022-05-11T14:09:55Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractThe aim of our study was to assess whether endothelial function of the brachial artery is normal or impaired in children born at term with low birth weight (LBW) compared with their normal birth weight (NBW) peers, because there are still few data on this subject in children born at term with LBW. We compared brachial artery flow mediated dilatation (FMD) in children with LBW (n= 55, 30 male) and NBW (n= 45, 24 male) who were born at term. Age, gender, weight, height, waist and hip circumference, body mass index, body mass Z score, fasting glucose, total cholesterol, triglycerides, low density lipoprotein-cholesterol, high density lipoprotein- cholesterol, calcium, C-reactive protein, hemoglobin, serum insulin concentration, homeostatic model assessment index, creatinine values, brachial artery baseline diameter and brachial artery post dilatation diameter were similar in both groups (all p values >0.05). Compared with the NBW group, the LBW group had lower FMD (%) (6.68 +/- 2.1 vs. 7.8 +/- 1.9, p = 0.004). Brachial artery FMD was negatively correlated with waist circumferences (r = - 0.521, p < 0.001). A general linear analysis model, FMD as the dependent variable revealed significant effect of waist circumference (ss +/- SE:- 0.07 +/- 0.02, p<0.001) and LBW controlling for age (ss +/- SE: -0.028 +/- 0.01, p = 0.004). LBW closely affects to FMD. Therefore, the children with LBW born at term may be potentially at risk for early atherosclerosis compared with their peers.
dc.identifier.doi10.5455/GMJ-30-2013-164
dc.identifier.endpage14
dc.identifier.issn2564-7784
dc.identifier.issn2564-7040
dc.identifier.issue1en_US
dc.identifier.startpage10
dc.identifier.urihttps://doi.org/10.5455/GMJ-30-2013-164
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5202
dc.identifier.volume20
dc.identifier.wosWOS:000439222100003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorAkkoyun, Dursun Çayan
dc.institutionauthorNalbanto?lu, Burçin
dc.institutionauthorTopçu, Birol
dc.institutionauthorTülübaş, Feti
dc.institutionauthorDonma, Mustafa Metin
dc.language.isoen
dc.publisherAves Press Ltd
dc.relation.ispartofEuropean Journal of Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAtherosclerosis
dc.subjectbirth weight
dc.subjectchildhood
dc.subjectflow mediated dilatation
dc.titleEndothelial dysfunction in children with low birth weight, born at term
dc.typeArticle

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