Is Biochemical Assessment of Pheochromocytoma Necessary in Adrenal Incidentalomas with Magnetic Resonance Imaging Features Not Suggestive of Pheochromocytoma?

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dc.authorid0000-0001-5584-4954
dc.authorid0000-0001-8084-848X
dc.authorwosidÖzel, Alper/AAL-3619-2020
dc.authorwosidÖztürk, Feyza Yener/AAL-3013-2020
dc.authorwosidZuhur, Sayid/AAC-6839-2020
dc.contributor.authorKuzu, İdris
dc.contributor.authorZuhur, Sayid Shafi
dc.contributor.authorÖzel, Alper
dc.contributor.authorÖztürk, Feyza Yener
dc.contributor.authorAltuntaş, Yüksel
dc.date.accessioned2022-05-11T14:39:54Z
dc.date.available2022-05-11T14:39:54Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: Currently, it is unclear whether pheochromocytomas can be ruled out based on low intensity on T2-weighted sequences and signal loss on out-of-phase magnetic resonance imaging (MRI) sequences. Hence, in this study, we investigated whether biochemical screening for pheochromocytoma in patients with adrenal incidentalomas (AIs) showing MRI features not suggesting pheochromocytoma would prove beneficial. Methods: We performed MRI for 300 AIs in 278 consecutive patients. All patients were screened for pheochromocytoma with plasma metanephrine and normetanephrine. Patients with high plasma levels of metanephrine and/or normetanephrine were also assessed for pheochromocytoma by urinary metanephrines. Results: Hyperintensity was detected on T2-weighted MRI sequences in 28 (9.3%) of the 300 AIs. Among these 28 incidentalomas, pheochromocytoma was diagnosed in 13 (46.4%) of the cases by histopathologic analysis. Hyperintensity on T2-weighted MRI was significantly higher in pheochromocytomas compared to the remaining AIs (P<.001). All 13 pheochromocytomas were characterized by hyperintensity on T2-weighted sequences and the absence of signal loss on out-of-phase MRI sequences. Pheochromocytoma was not detected in any of the 272 AIs that appeared hypointense or isointense on T2-weighted MRI sequences or in the 250 cases with signal loss on outof- phase sequences. Conclusion: The results of this study suggest that AIs that appear hypointense or isointense on T2-weighted MRI sequences and those with signal loss on out-of-phase sequences may not require routine biochemical screening for pheochromocytoma. Further studies including a higher number of pheochromocytomas are required to confirm our results.
dc.identifier.doi10.4158/EP151060.OR
dc.identifier.endpage539
dc.identifier.issn1530-891X
dc.identifier.issn1934-2403
dc.identifier.issue5en_US
dc.identifier.pmid26684154
dc.identifier.startpage533
dc.identifier.urihttps://doi.org/10.4158/EP151060.OR
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8789
dc.identifier.volume22
dc.identifier.wosWOS:000377969400002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorZuhur, Sayid Shafi
dc.language.isoen
dc.publisherAmer Assoc Clinical Endocrinologists
dc.relation.ispartofEndocrine Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectClinical-Practice Guideline
dc.subjectChemical-Shift
dc.subjectLipid Degeneration
dc.subjectMasses
dc.subjectCt
dc.subjectAdenomas
dc.subjectMri
dc.subjectDifferentiation
dc.subjectAppearances
dc.subjectMimicking
dc.titleIs Biochemical Assessment of Pheochromocytoma Necessary in Adrenal Incidentalomas with Magnetic Resonance Imaging Features Not Suggestive of Pheochromocytoma?
dc.typeArticle

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