Evaluation of heavy metal blood concentrations in patients with essential tremor: A preliminary study

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dc.authoridBahtiyar, Nurten/0000-0003-2420-8415
dc.contributor.authorKorucu, Ibrahim
dc.contributor.authorGundogdu, Asli Aksoy
dc.contributor.authorBahtiyar, Nurten
dc.date.accessioned2025-04-06T12:23:38Z
dc.date.available2025-04-06T12:23:38Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractEssential Tremor (ET) is one the most common mobility disorders, affecting 1% of the population. Both genetic and environmental factors may trigger the pathophysiology that eventually causes ET. Pb blood levels in ET patients have been studied. However, there are no clear data in the literature evaluating the blood levels of other heavy metals (aluminum, chromium, manganese, nickel, copper, zinc, cadmium, antimony, tin) in ET patients. We aimed to investigate the relationship between heavy metal blood levels and tremor characteristics of ET patients. A total of 110 ET patients and 146 healthy controls were included. The control group was subdivided into control-1 (52 patients' household members) and control-2 (94 unrelated healthy individuals). The average age of patients was 52.10 +/- 17.00 and that of the control group was 46.00 +/- 15.85. All patients underwent a detailed neurological examination, and scores on the Basic Tremor Evaluation Scale and Fahn-Tolosa-Marin Tremor Scales were recorded for the patient group. Peripheral blood samples were collected from all participants and heavy metal levels were examined and analyzed. The Al, Cd, Cr and Sb blood levels were statistically signifi- cantly higher in ET patients than in the control group (for Al: chi 2 =8.684, p=0.013, for Cd: F=7.883, p<0.001, for Cr: chi 2 =8.175, p=0.017, for Sb: chi 2 =9.075, p=0.011). The duration of the disease was found to be positively correlated with Al blood levels (r=0.227, p=0.017). Our results revealed that ET is associated with elevated blood levels of Al, Cd, Cr and Sb. Investigating the etiological role of heavy metals will enable the establishment of novel therapeutic approaches to prevent or cure ET.
dc.identifier.doi10.5601/jelem.2024.29.3.3373
dc.identifier.endpage1003
dc.identifier.issn1644-2296
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage987
dc.identifier.urihttps://doi.org/10.5601/jelem.2024.29.3.3373
dc.identifier.urihttps://hdl.handle.net/20.500.11776/17090
dc.identifier.volume29
dc.identifier.wosWOS:001417875600004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherPolish Society Magnesium Research
dc.relation.ispartofJournal of Elementology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250406
dc.subjectessential tremor
dc.subjectheavy metal
dc.subjectetiology
dc.subjecttoxicity
dc.subjectspectrometry
dc.titleEvaluation of heavy metal blood concentrations in patients with essential tremor: A preliminary study
dc.typeArticle

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