Colistin nephrotoxicity increases with age

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dc.authorid0000-0001-6133-9604
dc.authorid0000-0001-6133-9604
dc.authorid0000-0002-4543-8853
dc.authorid0000-0002-8977-5931
dc.authorid0000-0003-3055-9334
dc.authorid0000-0002-0244-4006
dc.authorid0000-0003-1514-1685
dc.authorwosidHakyemez, Ismail Necati/C-2271-2015
dc.authorwosidHakyemez, Ismail/J-2404-2015
dc.authorwosidbalkan, ilker inanc/AAI-1578-2019
dc.authorwosidOzkan, Ahmet Selim/ABH-2918-2020
dc.authorwosidAkbas, Sedat/ABI-6053-2020
dc.authorwosidDurdu, Bulent/I-7851-2016
dc.authorwosidTabak, Ömer Fehmi/A-1192-2018
dc.contributor.authorBalkan, İlker İnanç
dc.contributor.authorDoğan, Mustafa
dc.contributor.authorDurdu, Bülent
dc.contributor.authorBatırel, Ayşe
dc.contributor.authorHakyemez, İsmail N.
dc.contributor.authorÇetin, Birsen
dc.contributor.authorTabak, Fehmi
dc.date.accessioned2022-05-11T14:37:22Z
dc.date.available2022-05-11T14:37:22Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Colistin (COL) has become the backbone of the treatment of infections due to extensively drug-resistant (XDR) Gram-negative bacteria. The most common restriction to its use is acute kidney injury (AKI). Methods: We conducted a retrospective cohort study to evaluate risk factors for new-onset AKI in patients receiving COL. The cohort consisted of 198 adults admitted to 9 referral hospitals between January 2010 and October 2012 and treated with intravenous COL for >= 72 h. Patients with no pre-existing kidney dysfunction were compared in terms of risk factors and outcomes of AKI graded according to the RIFLE criteria. Logistic regression analysis was used to identify associated risk factors. Results: A total of 198 patients met the inclusion criteria, of whom 167 had no pre-existing kidney dysfunction; the mean patient age was 58.77 (+/- 18.98) y. Bloodstream infections (34.8%) and ventilator-associated pneumonia (32.3%) were the 2 most common indications for COL use. New-onset AKI developed in 46.1% of the patients, graded as risk (10%), injury (15%), and failure (21%). Patients with high Charlson co-morbidity index (CCI) scores (p = 0.001) and comparatively low initial glomerular filtration rate (GFR) estimations (p < 0.001) were more likely to develop AKI, but older age (p = 0.001; odds ratio 5.199, 95% confidence interval 2.684-10.072) was the major predictor in the multivariate analysis. In-hospital recovery from AKI occurred in 58.1%, within a median of 7 days. Conclusions: COL-induced nephrotoxicity occurred significantly more often in patients older than 60 y of age and was related to low initial GFR estimations and high CCI scores, which were basically determined by age.
dc.identifier.doi10.3109/00365548.2014.926021
dc.identifier.endpage685
dc.identifier.issn0036-5548
dc.identifier.issn1651-1980
dc.identifier.issue10en_US
dc.identifier.pmid25073536
dc.identifier.startpage678
dc.identifier.urihttps://doi.org/10.3109/00365548.2014.926021
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8669
dc.identifier.volume46
dc.identifier.wosWOS:000342202800002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorDoğan, Mustafa
dc.language.isoen
dc.publisherInforma Healthcare
dc.relation.ispartofScandinavian Journal of Infectious Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectColistin
dc.subjectnephrotoxicity
dc.subjectage
dc.subjectNegative Bacterial-Infections
dc.subjectCritically-Ill Patients
dc.subjectIntravenous Colistin
dc.subjectRisk-Factors
dc.subjectToxicity
dc.subjectTherapy
dc.subjectCohort
dc.subjectMethanesulfonate
dc.subjectAcinetobacter
dc.subjectPolymyxins
dc.titleColistin nephrotoxicity increases with age
dc.typeArticle

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