Prognostic markers of mortality in patients with methanol poisoning

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dc.authoridpayza, umut/0000-0002-5297-1066
dc.authorwosidpayza, umut/V-3421-2017
dc.contributor.authorKayalı, Ahmet
dc.contributor.authorPayza, Umut
dc.contributor.authorİriağaç, Yakup
dc.contributor.authorBilgin, Serkan
dc.contributor.authorEfgan, Mehmet Göktuğ
dc.contributor.authorCinaroglu, Osman Sezer
dc.date.accessioned2023-05-06T17:23:34Z
dc.date.available2023-05-06T17:23:34Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı
dc.description.abstractAim: Methanol is a kind of alcohol, which is used in industry in numerous different products. Methanol intoxication entails high mortality and morbidity rates. In this study, we aimed to investigate the effectiveness of laboratory parameters in determining the severity of exposure in patients presenting with methanol intoxication. Material and Methods: The study was performed in the university hospital between January 1, 2015, and January 1, 2020. All data were obtained retrospectively from the hospital automation system. Receiver Operating Characteristic (ROC) curve was used to determine ideal cut-off values. A logistic regression model was used to perform univariate and multivariate analyses. Results: The study included 49 patients and 3 of them were women. Thirty (61%) received both hemodialysis and intravenous ethanol for treatment. Univariate analysis revealed increased mortality in patients with pH below 7.00, HCO3 below 8.40 (mmol/L), lactate 4.35 (mmol/L), glucose 183 (mg/dl) and above, PCO2 42.7 (mmHg), high osmolarity, and a high anion gap. The results of multivariate logistic regression analysis for model 1 is (pH, bicarbonate, lactate, glucose, PCO2, osmolarity, and anion gap); pH <7.00 (OR:0.016, %95 CI <0.01-0.15, p<0.001) and for model 2 is (bicarbonate, lactate, glucose, PCO2, osmolarity, and anion gap); lactate >= 4.35 (OR:31.66, 95% CI 3.25-308.5, p=0.003) and PCO2 >= 42.7 (OR: 7.01, 95% CI 1.12-43.96, p=0.038). Discussion: Laboratory parameters would predict mortality. PH emerged as a predictive mortality marker, while blood lactate and high partial carbon dioxide pressure were capable of predicting mortality if pH was excluded. Starting on the treatment with clinical diagnoses decreases mortality in methanol intoxication.
dc.identifier.doi10.4328/ACAM.21225
dc.identifier.endpage1111
dc.identifier.issn2667-663X
dc.identifier.issue10en_US
dc.identifier.startpage1107
dc.identifier.urihttps://doi.org/10.4328/ACAM.21225
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12165
dc.identifier.volume13
dc.identifier.wosWOS:000886534700010
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorİriağaç, Yakup
dc.language.isoen
dc.publisherBayrakol Medical Publisher
dc.relation.ispartofAnnals Of Clinical And Analytical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMethanol
dc.subjectEmergency Department
dc.subjectPrognostic Markers
dc.subjectEthylene-Glycol
dc.subjectEpidemiology
dc.subjectOutbreak
dc.subjectIran
dc.titlePrognostic markers of mortality in patients with methanol poisoning
dc.typeArticle

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