Incidence, etiology, and antibiotic resistance patterns of Gram-negative microorganisms isolated from patients with ventilator-associated pneumonia in a medical-surgical hospital in Istanbul, intensive care unit of a teaching Turkey (2004-2006)

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dc.authorid0000-0002-4983-6613
dc.authorwosidInan, Asuman/D-5679-2014
dc.contributor.authorErdem, İlknur
dc.contributor.authorÖzgültekin, Asu
dc.contributor.authorİnan, Asuman Şengöz
dc.contributor.authorDinçer, Emine
dc.contributor.authorTuran, Güldem
dc.contributor.authorCeran, Nurgül
dc.contributor.authorGöktaş, Paşa
dc.date.accessioned2022-05-11T14:37:21Z
dc.date.available2022-05-11T14:37:21Z
dc.date.issued2008
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.description.abstractThe identification of microorganisms causing ventilator-associated pneumonia (VAP) is important for formulating appropriate therapies. In this study, we report the incidence, etiology, and antibiotic resistance patterns of Gram-negative microorganisms isolated from patients diagnosed with VAP in our medical-surgical intensive care unit (ICU) during the years 2004-2006. VAP was diagnosed by using the clinical criteria of the Centers for Disease Control and Prevention. Antibiotic resistance patterns of isolated microorganisms were defined by standard methods. The VAP incidence rate was 22.6/1,000 ventilator days. The most frequently isolated pathogens were Acinetobacter spp., methicillin-resistant Staphylococcus aureus, and Pseudomonas aeruginosa. Ninety percent of Acinetobacter spp. isolates were resistant to ceftazidime, 64% to imipenem, and 80% to ciprofloxacin. Fifty-nine percent of P. aeruginosa isolates were resistant to ceftazidime, 32% to imipenem, and 62% to ciprofloxacin. Cefoperazone-sulbactam was the most active agent against Acinetobacter spp. In conclusion, the incidence of VAP and the prevalence of multidrug-resistant microorganisms are quite high in our ICU. Comparison of the resistance rates of isolates demonstrates that certain antibiotic agents are more effective than others.
dc.identifier.endpage342
dc.identifier.issn1344-6304
dc.identifier.issn1884-2836
dc.identifier.issue5en_US
dc.identifier.pmid18806338
dc.identifier.startpage339
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8664
dc.identifier.volume61
dc.identifier.wosWOS:000259753900002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorErdem, İlknur
dc.language.isoen
dc.publisherNatl Inst Infectious Diseases
dc.relation.ispartofJapanese Journal of Infectious Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntimicrobial Resistance
dc.subjectSusceptibility Patterns
dc.subjectDiagnosis
dc.subjectSurveillance
dc.subjectPathogens
dc.titleIncidence, etiology, and antibiotic resistance patterns of Gram-negative microorganisms isolated from patients with ventilator-associated pneumonia in a medical-surgical hospital in Istanbul, intensive care unit of a teaching Turkey (2004-2006)
dc.typeArticle

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