Cyclooxygenase-2 and Vascular Endothelial Growth Factor Expression and Their Correlation with Angiogenesis in Gastric Carcinomas

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dc.authorwosidAktepe, Fatma/AAF-2184-2019
dc.contributor.authorEkici, Özlem
dc.contributor.authorTokyol, Çiğdem
dc.contributor.authorDilek, Fatma Hüsniye
dc.contributor.authorAktepe, Fatma
dc.contributor.authorŞahin, Onder
dc.contributor.authorŞahin, Dursun Ali
dc.date.accessioned2022-05-11T14:36:55Z
dc.date.available2022-05-11T14:36:55Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractObjective: The aim of this study was to investigate the expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in gastric carcinomas and lymph node metastasis and their relationship with angiogenesis and prognostic histopathological parameters. Materials and Methods: COX-2 and VEGF expression and microvessel density (MVD) grade identified by antibodies against CD34 were investigated immunohistochemically in 33 patients with gastric carcinoma. Results: The expression of COX-2 was 96.9% in normal mucosa and 87.8% in gastric carcinoma. Although COX-2 expression in mucosa was higher than in carcinoma, the difference was not statistically significant. The COX-2 positivity rates in lymph nodes were significantly higher in patients with vascular invasion (p<0.01). The expression of VEGF was 100% in normal mucosa and 93.9% in gastric carcinoma. VEGF levels in mucosa were significantly higher than in carcinoma (p=0.05). MVD grade in mucosa was significantly higher than in gastric carcinoma (p<0.01). MVD values were significantly higher in poorly differentiated carcinomas than in well and moderately differentiated carcinomas (p<0.05). There was no association between COX-2 and VEGF expression and MVD grade in tumor tissues and metastatic lymph nodes. There was no correlation of clinicopathological parameters with COX-2 and VEGF expression and MVD grade. Conclusion: Our results suggest that the MVD in gastric carcinoma may correlate with tumor grade, but the precise roles of COX-2 and VEGF in gastric cancers are not yet fully understood. Further studies with large series are needed to clarify the importance of COX-2, VEGF and MVD in cancer progression.
dc.identifier.doi10.4274/meandros.1038
dc.identifier.endpage10
dc.identifier.issn2149-9063
dc.identifier.issue1en_US
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.4274/meandros.1038
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8481
dc.identifier.volume17
dc.identifier.wosWOS:000406499800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorŞahin, Onder
dc.language.isotr
dc.publisherGalenos Yayincilik
dc.relation.ispartofMeandros Medical and Dental Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCOX-2
dc.subjectVEGF
dc.subjectangiogenesis
dc.subjectgastric carcinoma
dc.subjectimmunohistochemistry
dc.subjectCell Lung-Cancer
dc.subjectInvasive Breast-Carcinoma
dc.subjectPrognostic-Significance
dc.subjectMicrovessel Density
dc.subjectTumor Angiogenesis
dc.subjectOverexpression
dc.subjectAdenocarcinoma
dc.subjectMetastasis
dc.subjectInduction
dc.subjectNeoplasia
dc.titleCyclooxygenase-2 and Vascular Endothelial Growth Factor Expression and Their Correlation with Angiogenesis in Gastric Carcinomas
dc.typeArticle

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