Evidence for the involvement of neuronal nitric oxide synthase and soluble guanylate cyclase on cognitive functions in rats

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dc.authorid0000-0001-7341-4907
dc.authorid0000-0003-0952-0742
dc.authorid0000-0003-0895-3490
dc.authorid0000-0001-5848-3680
dc.authorscopusid35331721100
dc.authorscopusid11440747800
dc.authorscopusid13405968200
dc.authorscopusid6603418006
dc.authorscopusid10638814800
dc.authorscopusid7003362092
dc.authorwosidgocmez, semil selcen/G-2401-2018
dc.authorwosidUtkan, Tijen/G-2398-2018
dc.authorwosidMUTLU, OGUZ/F-5952-2018
dc.authorwosidAricioglu, Feyza/ABI-4003-2020
dc.authorwosidARICIOGLU, FEYZA/AAR-5704-2020
dc.authorwosidCelikyurt, Ipek Komsuoglu/F-7363-2018
dc.contributor.authorKomsuoglu-Çelikyurt, Ipek
dc.contributor.authorGöçmez, Semil Selcen
dc.contributor.authorMutlu, Oğuz
dc.contributor.authorGacar, Nejat
dc.contributor.authorArıcıoğlu, Feyza
dc.contributor.authorUtkan, Tijen
dc.date.accessioned2022-05-11T14:41:08Z
dc.date.available2022-05-11T14:41:08Z
dc.date.issued2011
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractAims: The influence of 3-bromo-7-nitroindazole (3-Br 7-NI), a potent and selective neuronal nitric oxide synthase (nNOS) inhibitor, and [1H-[1,2,4]-oxadiazole[4,3a]-quinoxaline-1-one] (ODQ), a highly selective, irreversible inhibitor of soluble guanylate cyclase (sGC), on working and reference memory and emotional learning was investigated in rats. Main methods: The effects were assessed in the three-panel runway and step-down passive avoidance task. respectively. Key findings: 3-Br 7-NI (5, 10, and 20 mg/kg) and ODQ (5, 10, and 20 mg/kg) significantly increased the number of errors and latency of both working and reference memory performance of rats and impaired retention for the passive avoidance task. The effect of 3-Br 7-NI was reversed by L-arginine (250 mg/kg). Significance: Findings of the study supported the hypothesis that nNOS inhibition disrupts reference and working memory processes in terms of an impairment in the strategies used for solving learning tasks, and, according to these results, nNOS-sGC may be required for emotional learning and both reference and working memory. (C) 2011 Elsevier Inc. All rights reserved.
dc.description.sponsorshipKocaeli UniversityKocaeli University [2007-2010/39]
dc.description.sponsorshipThis study was supported by a grant from Kocaeli University Research Fund (Project number: 2007-2010/39) and preliminary findings of the study was presented at the 9th World Congress of Biological Psychiatry, June 28-July 2, 2009, Paris-France.
dc.identifier.doi10.1016/j.lfs.2011.09.017
dc.identifier.endpage910
dc.identifier.issn0024-3205
dc.identifier.issn1879-0631
dc.identifier.issue23-24en_US
dc.identifier.pmid21993262
dc.identifier.scopus2-s2.0-81255135817
dc.identifier.scopusqualityQ1
dc.identifier.startpage905
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2011.09.017
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9081
dc.identifier.volume89
dc.identifier.wosWOS:000297486100012
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGöçmez, Semil Selcen
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofLife Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject3-bromo-7-nitroindazole
dc.subjectODQ
dc.subjectNO
dc.subjectGuanylate cyclase
dc.subjectWorking memory
dc.subjectReference memory
dc.subjectEmotional learning
dc.subjectRats
dc.subjectLong-Term Potentiation
dc.subjectMemory Formation
dc.subjectImpairs Retention
dc.subjectProtein-Kinase
dc.subjectInhibition
dc.subjectCgmp
dc.subjectMice
dc.subjectNitration
dc.subjectTask
dc.subjectNeurodegeneration
dc.titleEvidence for the involvement of neuronal nitric oxide synthase and soluble guanylate cyclase on cognitive functions in rats
dc.typeArticle

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