Effect of U-92032, T-Type Ca(2+)Channel Blocker, on Rats with Genetic Absence Epilepsy

Basit Öğe Kaydı
dc.authorid0000-0003-4649-3632
dc.authorid0000-0002-1519-3170
dc.authorid0000-0001-8717-4342
dc.authorwosidGülhan, Rezzan/ABE-8378-2021
dc.authorwosidYANANLI, Hasan/AAB-2578-2021
dc.authorwosidDemirkapu, Mahluga Jafarova/AAI-3130-2020
dc.authorwosidAKER, REZZAN GULHAN/A-2995-2010
dc.contributor.authorYananlı, Hasan Raci
dc.contributor.authorDemirkapu, Mahluga Jafarova
dc.contributor.authorSakallı, Halil Eren
dc.contributor.authorGülhan, Rezzan
dc.contributor.authorOnat, Filiz Yılmaz
dc.date.accessioned2022-05-11T14:05:10Z
dc.date.available2022-05-11T14:05:10Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractIntroduction:Absence epilepsy is associated with diffuse spike-and-wave discharges (SWD) on the electroencephalogram (EEG). Recent studies have demonstrated that the primary somatosensory cortex is also implicated in the generation of the SWDs.Objective:This study investigated the effects of systemic and local administrations of U-92032 into the brain of Genetic Absence Epilepsy Rats from Strasbourg (GAERS).Methods:GAERS animals underwent stereotaxic surgery for the placement of EEG recording electrodes and guide cannulas for U-92032 administration into the lateral ventricle (intracerebroventricular [i.c.v.]), upper lips area (S1Ulp) or barrel field area (S1B) of primary somatosensory cortex. Following 7 days of recovery, electrical activity was recorded continuously for 1 h before and 6 h after intraperitoneal (0.25; 1; 5 mg/kg i.p.) or local U-92032 or dimethyl sulfoxide (DMSO) injections.Results:No changes were detected in the cumulative duration, mean duration, and number of SWDs following i.p. U-92032 injections. Local i.c.v. injections of U-92032 caused a significant decrease in the cumulative duration (i.c.v., 50 and 100 nmol/L), mean duration (i.c.v., 50, 100, and 250 nmol/L), and the number (i.c.v., 250 nmol/L) of SWDs compared to DMSO groups. Intra-cortical (S1Ulp and S1B) U-92032 injections caused a significant decrease in all 3 parameters compared to DMSO groups, as well.Conclusion:Intra-cortical injection of U-92032 caused almost complete removal of SWDs in GAERS and i.c.v. administration resulted in a significant reduction. However, systemic i.p. administration did not cause a significant change with the applied -doses.
dc.identifier.doi10.1159/000505215
dc.identifier.endpage567
dc.identifier.issn0031-7012
dc.identifier.issn1423-0313
dc.identifier.issue45574en_US
dc.identifier.pmid32101873
dc.identifier.startpage561
dc.identifier.urihttps://doi.org/10.1159/000505215
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4910
dc.identifier.volume105
dc.identifier.wosWOS:000579124400009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorDemirkapu, Mahluga Jafarova
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofPharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEpilepsy
dc.subjectCalcium channel blocker
dc.subjectSpike-and-wave discharges
dc.subjectCortex
dc.subjectRats
dc.subjectCalcium-Channel
dc.subjectMolecular Characterization
dc.subjectEthosuximide
dc.subjectSeizures
dc.subjectExpression
dc.subjectThalamus
dc.subjectCloning
dc.subjectMembers
dc.subjectModel
dc.titleEffect of U-92032, T-Type Ca(2+)Channel Blocker, on Rats with Genetic Absence Epilepsy
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
4910.pdf
Boyut:
329.62 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Tıp Fakültesi Koleksiyonu