Association of Fetuin-A with Carotid Intima-Media Thickness and Vascular Diseases

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dc.contributor.authorAkyüz, Aydın
dc.coverage.doi10.1007/978-94-007-7678-4
dc.date.accessioned2022-05-11T14:40:08Z
dc.date.available2022-05-11T14:40:08Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractFetuin-A, also known as alpha 2-Heremans-Schmid glycoprotein (AHSG), is a member of the cystatin superfamily of cysteine protease inhibitors and has different functions in human physiology and pathophysiology. Most studies suggest a biphasic effect of fetuin-A depending on the stages of atherosclerosis. Serum levels of fetuin-A are decreased in cases of acute inflammation. Therefore, it is known as a negative acute-phase protein. Fetuin-A inhibits insulin signaling and pathological calcification and has emerged as a diabetogenic agent. Fetuin-A levels are also found to be related to visceral obesity and dyslipidemia. Some authors have claimed that fetuin-A has a proatherogenic role, but it is still unclear whether high fetuin-A levels accelerate atherosclerosis except in the case of diabetes mellitus (DM). One of the most important reasons for this uncertainty is the fact that there is a very weak compatibility between fetuin-A measurements performed by two different commercial enzyme-linked immunosorbent assay (ELISA) kits. Because the early sign of atherosclerosis is carotid intima-media thickness (CIMT), attention has been drawn to the relationship between CIMT and fetuin-A, especially in patients with DM. A number of studies in the literature have demonstrated an inverse correlation between fetuin-A and CIMT in patients who had chronic inflammatory disease but not DM. In addition, there is no association between fetuin-A and CIMT in subjects without known clinical cardiovascular disease. However, it seems that high fetuin-A levels accelerate atherosclerosis in DM and that diabetic patients exhibit a positive correlation between fetuin-A and CIMT.
dc.identifier.doi10.1007/978-94-007-7678-4_16
dc.identifier.endpage196
dc.identifier.isbn978-94-007-7678-4
dc.identifier.isbn978-94-007-7677-7
dc.identifier.issn2542-3657
dc.identifier.startpage177
dc.identifier.urihttps://doi.org/10.1007/978-94-007-7678-4_16
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8880
dc.identifier.wosWOS:000425058500010
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorAkyüz, Aydın
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofBiomarkers in Cardiovascular Disease, Vols 1 and 2
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFetuin-A
dc.subjectCarotid intima-media thickness
dc.subjectArterial stiffness
dc.subjectAtherosclerosis
dc.subjectInflammation
dc.subjectAlpha(2)-Heremans-Schmid Glycoprotein/Fetuin-A
dc.subjectCoronary-Artery-Disease
dc.subjectAmino-Acid-Sequence
dc.subjectSubclinical Atherosclerosis
dc.subjectCardiovascular-Disease
dc.subjectMyocardial-Infarction
dc.subjectInsulin-Resistance
dc.subjectTyrosine Kinase
dc.subjectRisk-Factors
dc.subjectSerum
dc.titleAssociation of Fetuin-A with Carotid Intima-Media Thickness and Vascular Diseases
dc.typeBook Chapter

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