Zeolite 4A as a jammer of bacterial communication in Chromobacterium violaceum and Pseudomonas aeruginosa

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dc.authoridOral, Ayhan/0000-0003-4965-8754
dc.authoridTinaz, Gulgun/0000-0003-1080-4419
dc.contributor.authorUlusoy, Seyhan
dc.contributor.authorAkalın, Ramadan Bilgin
dc.contributor.authorÇevikbaş, Halime
dc.contributor.authorBerisha, Avni
dc.contributor.authorOral, Ayhan
dc.contributor.authorBosgelmez-Tinaz, Gulgun
dc.date.accessioned2023-04-20T08:01:20Z
dc.date.available2023-04-20T08:01:20Z
dc.date.issued2022
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü
dc.description.abstractAim: To investigate the hypothesis that zeolites interfere with quorum-sensing (QS) systems of Chromobacterium violaceum and Pseudomonas aeruginosa by adsorbing N-acyl homoserine lactone (AHL) signal molecules. Methods: QS inhibition by zeolite 4A was investigated using an AHL-based bioreporter assay. The adsorption of the AHLs was evaluated by performing inductively coupled plasma-optical emission spectroscopy and confirmed by Monte Carlo and molecular dynamic simulations. Results: Zeolite 4A reduced the violacein production in C. violaceum by over 90% and the biofilm formation, elastase and pyocyanin production in P. aeruginosa by 87, 68 and 98%, respectively. Conclusion: Zeolite 4A disrupts the QS systems of C. violaceum and P. aeruginosa by means of adsorbing 3-oxo-C6-AHL and 3-oxo-C12-AHL signaling molecules and can be developed as a novel QS jammer to combat P. aeruginosa-related infections.
dc.identifier.doi10.2217/fmb-2021-0174
dc.identifier.endpage871
dc.identifier.issn1746-0913
dc.identifier.issn1746-0921
dc.identifier.issue11en_US
dc.identifier.pmid35658574
dc.identifier.startpage861
dc.identifier.urihttps://doi.org/10.2217/fmb-2021-0174
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10880
dc.identifier.volume17
dc.identifier.wosWOS:000806215100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorAkalın, Ramadan Bilgin
dc.language.isoen
dc.publisherFuture Medicine Ltd
dc.relation.ispartofFuture Microbiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiofilms
dc.subjectModeling
dc.subjectPseudomonas Aeruginosa
dc.subjectQuorum Sensing
dc.subjectQuorum Sensing Inhibitors
dc.subjectBiofilm Formation
dc.subjectEssential Oils
dc.subjectGenes
dc.subjectDerivatives
dc.subjectAdsorption
dc.subjectExpression
dc.subjectVirulence
dc.subjectEnzyme
dc.subjectSteel
dc.titleZeolite 4A as a jammer of bacterial communication in Chromobacterium violaceum and Pseudomonas aeruginosa
dc.typeArticle

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Sağlık Hizmetleri Meslek Yüksekokulu