Yazar "Uyan, Umut" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Öğe
    Could the Systemic Inflammatory Response Index be a Marker for the Non-Dipper Pattern in Newly Diagnosed Hypertensive Patients?
    (Humana Press Inc, 2025) Kaplangoray, Mustafa; Toprak, Kenan; Caglayan, Cuneyt; Deveci, Edhem; Celik, Enes; Uyan, Umut; Aydin, Cihan
    Systemic inflammatory response index (SIRI), is associated with prognosis in coronary artery disease (CAD), heart failure (HF), and acute myocardial infarction. This study investigated the relationship between SIRI and non-dipper hypertension. The study retrospectively included a total of 254 naive, newly diagnosed hypertensive individuals based on ambulatory blood pressure monitoring (ABPM), containing 166 dippers (DHT) and 88 non-dippers (NDHT). The SIRI value of all patients was calculated based on neutrophil, monocyte, and lymphocyte counts. The average age of study population was 50.7 +/- 9.4 years old, and the male ratio was 68.5%. Compared with DHT, patients in the NDHT group had higher SIRI, monocyte to HDL-C ratio (MHR), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), C-reactive protein (CRP), and neutrophil count, while high-density lipoprotein cholesterol (HDL-C) and lymphocyte count were lower (p < 0.05). The left ventricular mass index (LVMI) was higher in the NDHT group (p < 0.05). Multivariate logistic regression analysis showed that SIRI, LVMI, and HDL-C were independent predictor factors for NDHT. ROC curve analysis determined the optimal SIRI cut-off value for predicting NDHT diagnosis to be 2.41 (sensitivity 69.3%, specificity 64.5%, area under the receiver operating characteristic curve, 0.743; p < 0.001). The AUC values obtained for SIRI, MHR, NLR, PLR, HDL-C, and LVMI parameters in the ROC curve analysis were compared pairwise. The results demonstrated that SIRI's discriminative capacity in predicting NDHT was superior to all other indices. SIRI is an independent and significant predictor factor for NDHT and is superior in predicting NDHT diagnosis compared with HDL-C, MHR, LVMI, NLR, and PLR.
  • Küçük Resim Yok
    Öğe
    Evaluation of Tp-e/QTc Ratio in Obesity
    (Galenos Publ House, 2024) Uyan, Umut; Aydin, Cihan; Demirkiran, Aykut; Karadeniz, Muhammed; Alpsoy, Seref
    Aim: We aimed to detect simple findings that might predict sudden cardiac death in electrocardiography recordings in obese patients. Materials and Methods: Patients were included in our study retrospectively. Two groups with body mass index (BMI) >= 30 kg/m(2) (Group 1) and BMI <30 kg/m(2) (Group 2) were sampled from the study population with similar baseline characteristics, biochemical and echocardiographic features. Ventricular repolarization parameters were compared between the two groups. The Tp-e interval was defined as the period of time between the T waves' peak and their end. Tp-e/QTc ratio was calculated. Results: This study included 190 participants. There were no differences between the two groups in terms of age (p=0.42), diabetes (p=0.238), hypertension (p=0.877), smoking (p=1.000), medical treatment used, laboratory parameters, left ventricular ejection fraction (p=0.673), and left ventricular mass index (p=0.089). The QTc interval was similar between the groups (416.4 +/- 11.6 ms, and 422.1 +/- 14.8 ms; p=0.081). Tp-e, and Tp-e/QTc ratio were greater in Group 1 (93.1 +/- 6.2 ms, and 67.7 +/- 2.5 ms; p=0.00; 0.22 +/- 0.02, and 0.15 +/- 0.01; p=0.001). Twelve months after the first examinations, six deaths were noted in the obese group (p=0.001). Conclusion: Our study results showed that the Tp-e interval and Tp-e/QTc ratio were significantly increased, and sudden cardiac death was more common in patients with BMI >= 30 kg/m(2).
  • Küçük Resim Yok
    Öğe
    Role of simple inflammatory parameters in predicting the severity of coronary artery disease
    (Assoc Medica Brasileira, 2023) Aydin, Cihan; Uyan, Umut; Karadeniz, Muhammed; Demirkiran, Aykut
    OBJECTIVE: In our study, we aimed to find simple, useful biomarkers in patients with non-ST elevation myocardial infarction to predict coronary artery severity.METHODS: Between May 2022 and December 2022, patients diagnosed with non-ST elevation myocardial infarction according to the European cardiology guidelines were included in our study. The Synergy between PCI with Taxus and Cardiac Surgery score was calculated to determine the severity of coronary artery disease. These patients were classified into two groups according to Synergy between PCI with Taxus and Cardiac Surgery >= 23 and Synergy between PCI with Taxus and Cardiac Surgery<23 scores. Biochemical markers such as platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio were studied in blood tests taken before coronary angiography in patients diagnosed with non-ST elevation myocardial infarction according to current guidelines. These two groups were compared in terms of the data obtained.RESULTS: There were 281 patients in group 1 and 67 patients in group 2. There was no significant difference between the two groups in terms of demographic data such as age and gender. Platelet-to-lymphocyte ratio [group 1=125 (26-134) and group 2=156 (73-293); p=0.001] and neutrophil-to-lymphocyte ratio [group 1=2.71 (1.3-30.2) and group 2=3.2 (2.1-32.1); p=0.002] were higher in the group of patients with a Synergy between PCI with Taxus and Cardiac Surgery score of <23, while lymphocyte-to-monocyte ratio [group 1=3.6 (0.56-11) and group 2=3.4 (0.64-5.75); p=0.017] was lower in group 2.CONCLUSION: We observed that elevated platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios showed coronary artery severity. Multivessel disease and chronic total occlusion rates were observed to be higher in patients with high platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios.