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Öğe A comparison of the effects of different classes of antidepressants on penile constitutive nitric oxide synthase of male rats(Elsevier Science Bv, 2012) Yazır, Yağız Alp; Göçmez, Semil Selcen; Utkan, Tijen; Gacar, Nejat; Arıcıoğlu, Feyza[No Abstract Available]Öğe Agmatine, a metabolite of L-arginine, reverses scopolamine-induced learning and memory impairment in rats(Pergamon-Elsevier Science Ltd, 2012) Utkan, Tijen; Göçmez, Semil Selcen; Regunathan, Soundararajan; Arıcıoğlu, FeyzaAgmatine (1-amino-4-guanidino-butane), a metabolite of L-arginine through the action of arginine decarboxylase, is a novel neurotransmitter. In the present study, effects of agmatine on cognitive functions have been evaluated by using one trial step-down passive avoidance and three panel runway task. Agmatine (20, 40, 80 mg/kg i.p.) was administered either in the presence or absence of a cholinergic antagonist, scopolamine (1 mg/kg i.p.). Scopolamine significantly impaired learning and memory in both passive avoidance and three panel runway test. Agmatine did not affect emotional learning, working and reference memory but significantly improved scopolamine-induced impairment of learning and memory in a dose dependent manner. Our results indicate that agmatine, as an endogenous substance, may have an important role in modulation of learning and memory functions. (c) 2012 Elsevier Inc. All rights reserved.Öğe Beneficial effects of resveratrol on scopolamine but not mecamylamine induced memory impairment in the passive avoidance and Morris water maze tests in rats(Pergamon-Elsevier Science Ltd, 2011) Gacar, Nejat; Mutlu, Oğuz; Utkan, Tijen; Çelikyurt, İpek Komşuoğlu; Göçmez, Semil Selcen; Ulak, GunerResveratrol (3,5,4-trihydroxy-trans-stilbene), which is found in grapes and red wine has been shown to protect neuronal cells with its antioxidant activity, improve memory function in dementia and reverse acetylcholine esterase (AChE) activity. The aim of this study was to investigate the effect of resveratrol on emotional and spatial memory in naive rats, as well as on scopolamine- and mecamylamine-induced memory impairment in the passive avoidance and Morris water maze (MWM) tests. Resveratrol (12.5, 25 and 50 mg/kg), scopolamine (0.6 mg/kg) and mecamylamine (10 mg/kg) were administered to male Wistar rats. In the passive avoidance test, there was no significant difference in the first day latency between all groups, whereas scopolamine and mecamylamine significantly shortened the second day latency compared to the control group. Resveratrol reversed the effect of scopolamine at all doses used, but it had no effect on mecamylamine-induced memory impairment in the passive avoidance test. Both scopolamine and mecamylamine significantly decreased the time spent in the escape platform quadrant during the probe trial of the MWM test compared to the control group. Resveratrol reversed the effect of scopolamine at all doses, but did not change the effect of mecamylamine in the MWM test. There were no significant differences in the locomotor activities of any of the groups. In conclusion, we suggested that resveratrol had improving effects on learning and memory by acting on muscarinic cholinergic receptors and at least in part, may reverse AChE activity. (C) 2011 Elsevier Inc. All rights reserved.Öğe Chronic administration of fluoxetine impairs neurogenic and endothelium-dependent relaxation of the rabbit corpus cavernosum smooth muscle(Elsevier, 2011) Göçmez, Semil Selcen; Utkan, Tijen; Gacar, Nejat; Sarıoğlu, YusufAntidepressants, including selective serotonin reuptake inhibitors (SSRIs), cause erectile dysfunction: however, the mechanism by which they cause erectile function is unclear. We investigated the reactivity of the corpus cavernosum after chronic fluoxetine treatment in rabbits. Twelve rabbits were randomly divided into two groups: control (n = 6) or 20 mg/kg/day of fluoxetine delivered i.p. (n = 6). The reactivity of the corpus cavernosum tissue from the fluoxetine-treated and control groups was studied in organ chambers after 21 days of fluoxetine injection. In the fluoxetine-treated group, endothelium-dependent relaxation of the corpus cavernosum in response to acetylcholine was significantly decreased compared to the control group. However, the sensitivity (i.e., pD(2)) of the fluoxetine-treated cavernosal tissue strips to acetylcholine was not changed with respect to controls. Electrical field stimulation (EFS)-induced neurogenic relaxation was also significantly reduced in the fluoxetine-treated group. Relaxation in response to the nitric oxide (NO) donor sodium nitroprusside was similar between the cavernosal tissues from the two groups. There was also no change in agonist potency between the two groups. Additionally, chronic fluoxetine treatment had no effect on KCl-induced contractile responses. When tissue contraction was produced with phenylephrine to study relaxation in response to various stimuli, the tension induced was similar between the fluoxetine-treated and control groups. This study suggests that chronic fluoxetine treatment causes significant functional changes to the penile erectile tissue of rabbits, and these changes may contribute to the development of impotence. (C) 2011 Elsevier B.V. All rights reserved.Öğe Chronic administration of imipramine but not agomelatine and moclobemide affects the nitrergic relaxation of rabbit corpus cavernosum smooth muscle(Elsevier, 2013) Göçmez, Semil Selcen; Utkan, Tijen; Gacar, NejatSexual dysfunction is a common and underestimated effect of antidepressants. However, the mechanism by which these drugs cause erectile dysfunction is unclear. We investigated the reactivity of the corpus cavernosum of rabbits that were treated with either chronic imipramine, which is a tricyclic agent; agomelatine, which is a melatonergic agonist and serotonin 5HT(2c) antagonist; or moclobemide, which is a reversible inhibitor of monoamine-oxidase A. Twenty rabbits were randomly divided into four groups: the control group (n = 5), the imipramine-treated group (n = 5), which received i.p. injections of 10 mg/kg/day of imipramine, the moclobemide-treated group (n = 5), which received i.p injections of 20 mg/kg/day of moclobemide, and the agomelatine-treated group (n = 5), which was orally administered 10 mg/kg/day of agomelatine. The reactivities of corpus cavernosum tissue obtained from the antidepressant-treated and the control groups were studied in organ chambers after the animals were subjected to 21 days of drug administration. The acetylcholine-induced endothelium-dependent and the electrical field stimulation (EFS)-induced neurogenic relaxation of the corpus cavernosum of the imipramine-treated group was significantly decreased compared with the control group. However, neither the acetylcholine- nor EFS-induced relaxation was changed in the moclobemide- or agomelatine-treated groups. There were no change in the relaxant response to the nitric oxide (NO) donor sodium nitroprusside and contractile response to KCl between the groups. This study suggests that chronic imipramine treatment but not agomelatine and moclobemide treatments causes significant functional changes in the penile erectile tissue of rabbits and that these changes may contribute to the development of impotence. (c) 2013 Elsevier B.V. All rights reserved.Öğe Chronic moderate alcohol consumption induces iNOS expression in the penis: An immunohistochemical study(Tubitak Scientific & Technical Research Council Turkey, 2014) Gonca, Suheyla; Yazir, Yusufhan; Göcmez, Semil Selcan; Dalcık, Ekim Nur; Utkan, Tijen; Dalcık, HakkiAim: To investigate the effect of moderate alcohol consumption on metabolic alterations, inducible nitric oxide synthase (iNOS), immunohistochemical distribution, and morphological damage to penile erectile tissue in rats. Materials and methods: Male Wistar albino rats were divided into 2 groups. Group 1 rats (control group, n = 8) received tap water ad libitum, and group 2 rats (n = 8) were fed with 20% ethanol. Increasing levels of alcohol were given to the rats over 12 weeks. Immunohistochemistry was then performed using the avidin-biotin-peroxidase technique on 5-mu m thickness tissue sections. Stained sections were examined by imaging microscope. Results: Alcohol consumption resulted in a significant increase in iNOS immunoreactivity in the penile erectile tissue. Increased iNOS expression was determined in the tunica albuginea, cavernosal smooth muscle cells, trabeculae of connective tissue, arterioles, and the urethral epithelium. Moreover, chronic alcohol consumption resulted in decreasing serum testosterone and high density lipoprotein (HDL) levels with increasing cholesterol and triglyceride levels. Conclusion: Chronic moderate alcohol consumption can affect penile erectile tissue by increasing iNOS immunoreactivity and induce histopathological damage such as penile fibrosis. These abnormalities are also related to the defense mechanism against morphological damage.Öğe Effect of harmane, an endogenous beta-carboline, on learning and memory in rats(Pergamon-Elsevier Science Ltd, 2013) Çelikyurt, İpek Komşuoğlu; Utkan, Tijen; Göçmez, Semil Selcen; Hudson, Alan; Arıcıoğlu, FeyzaOur aim was to investigate the effects of acute harmane administration upon learning and memory performance of rats using the three-panel runway paradigm and passive avoidance test. Male rats received harmane (2.5, 5, and 7.5 mg/kg, i.p.) or saline 30 min. before each session of experiments. In the three panel runway paradigm, harmane did not affect the number of errors and latency in reference memory. The effect of harmane on the errors of working memory was significantly higher following the doses of 5 mg/kg and 7.5 mg/kg. The latency was changed significantly at only 7.5 mg/kg in comparison to control group. Animals were given pre-training injection of harmane in the passive avoidance test in order to determine the learning function. Harmane treatment decreased the retention latency significantly and dose dependently, which indicates an impairment in learning. In this study, harmane impaired working memory in three panel runway test and learning in passive avoidance test. As an endogenous bioactive molecule, harmane might have a critical role in the modulation of learning and memory functions. (c) 2012 Elsevier Inc. All rights reserved.Öğe Effect of resveratrol on BDNF in a chronic unpredictable mild stress model: an immunohistochemical study(Elsevier Science Bv, 2012) Yazır, Y.; Göçmez, Semil Selcen; Utkan, Tijen; Kurnaz, S.; Gacar, Nejat; Arıcıoğlu, Feyza[No Abstract Available]Öğe Effect of resveratrol on penile neuronal and endothelial nitric oxide synthase expression in chronic unpredictable mild stress depression model(Elsevier Science Bv, 2015) Yazır, Yağız Alp; Demirtaş Şahin, Tuğçe; Göçmez, Semil Selcen; Utkan, Tijen; Gacar, Nejat[No Abstract Available]Öğe Effects of chronic etanercept, a TNF-alpha inhibitor, on cognitive deficits in diabetic rats(Elsevier Science Bv, 2013) Göçmez, Semil Selcen; Utkan, Tijen; Karson, A.; Bayramgurler, D.[No Abstract Available]Öğe Effects of chronic etanercept, a TNF-alpha inhibitor, on cognitive dysfunction in cafeteria diet-fed rats(Elsevier Science Bv, 2015) Demirtaş, T.; Utkan, Tijen; Göçmez, Semil Selcen; Karson, A.[No Abstract Available]Öğe Effects of chronic low- and high-dose ethanol intake on the nitrergic relaxations of corpus cavernosum and penile nitric oxide synthase in the rabbit(Nature Publishing Group, 2012) Yazır, Y.; Göçmez, Semil Selcen; Utkan, Tijen; Komşuoğlu Çelikyurt, I.; Gacar, Nejat; Sarıoğlu, Y.Epidemiological evidence showed that chronic ethanol consumption is a major risk factor in the development of impotence. The present study investigated the effects of carbachol-, electrical field stimulation (EFS)-, sodium nitroprusside (SNP)- and papaverine-induced relaxant responses in the isolated corpus cavernosum tissues from rabbits submitted to an 12-week course of chronic low (5% v/v) or high ethanol intake (30% v/v). Increased carbachol- and EFS-induced relaxant responses but not SNP and papaverine, were observed in low ethanol-fed rabbits compared with controls. However, impaired carbachol- and EFS-induced relaxant responses were observed in high ethanol-fed rabbits compared with control rabbits. There were no significant differences in SNP- and papaverine-induced relaxant responses between control and high ethanol-fed rabbits. In addition, decreased neuronal nitric oxide synthase (nNOS) and endothelial NOS (eNOS) immunoreactivity in penile tissue were found in high ethanol-fed rabbits, but increased the immunoreactivity in low ethanol-fed group, compared with control group. These results suggest that alterations in nitric oxide (NO) production within the cavernous tissue in the high ethanol-fed rabbits are, at least in part, responsible for the erectile dysfunction.Öğe Effects of chronic treatment with fluoxetine, moclobemide and agomelatine on rat isolated thoracic aorta(Elsevier Science Bv, 2013) Göçmez, Semil Selcen; Özer, Cengiz; Şahin, D.; Karadenizli, Sabriye; Utkan, Tijen[No Abstract Available]Öğe Effects of resveratrol on scopolamine and mecamylamine induced memory impairment in rats(Elsevier Science Bv, 2010) Gacar, Nejat; Utkan, Tijen; Mutlu, Oğuz; Göçmez, Semil Selcen; Çelikyurt, İpek Komşuoğlu; Ulak, G.[No Abstract Available]Öğe Evidence for the involvement of neuronal nitric oxide synthase and soluble guanylate cyclase on cognitive functions in rats(Pergamon-Elsevier Science Ltd, 2011) Komsuoglu-Çelikyurt, Ipek; Göçmez, Semil Selcen; Mutlu, Oğuz; Gacar, Nejat; Arıcıoğlu, Feyza; Utkan, TijenAims: The influence of 3-bromo-7-nitroindazole (3-Br 7-NI), a potent and selective neuronal nitric oxide synthase (nNOS) inhibitor, and [1H-[1,2,4]-oxadiazole[4,3a]-quinoxaline-1-one] (ODQ), a highly selective, irreversible inhibitor of soluble guanylate cyclase (sGC), on working and reference memory and emotional learning was investigated in rats. Main methods: The effects were assessed in the three-panel runway and step-down passive avoidance task. respectively. Key findings: 3-Br 7-NI (5, 10, and 20 mg/kg) and ODQ (5, 10, and 20 mg/kg) significantly increased the number of errors and latency of both working and reference memory performance of rats and impaired retention for the passive avoidance task. The effect of 3-Br 7-NI was reversed by L-arginine (250 mg/kg). Significance: Findings of the study supported the hypothesis that nNOS inhibition disrupts reference and working memory processes in terms of an impairment in the strategies used for solving learning tasks, and, according to these results, nNOS-sGC may be required for emotional learning and both reference and working memory. (C) 2011 Elsevier Inc. All rights reserved.Öğe P.4.c.003 Resveratrol shows vasoprotective effect in an unpredictable chronic mild stress model of depression in rats(Elsevier Science Bv, 2014) Göçmez, Semil Selcen; Gacar, G.; Yazir, Y.; Utkan, Tijen; Gacar, Nejat[No Abstract Available]Öğe Protective effects of an extract of propolis in scopolamine-induced cognitive impairment in rats(Elsevier Science Bv, 2015) Göçmez, Semil Selcen; Demirtaş, T.; Aksoz, E.; Utkan, Tijen; Gacar, Nejat[No Abstract Available]Öğe Protective effects of metformin in scopolamine-induced cognitive impairment in rats(Elsevier Science Bv, 2015) Aksöz, Elif; Göçmez, Semil Selcen; Demirtaş, Tuğçe; Utkan, Tijen[No Abstract Available]Öğe Protective effects of resveratrol in aging-induced cognitive impairment in rats(Elsevier Science Bv, 2013) Göçmez, Semil Selcen; Gacar, Nejat; Utkan, Tijen[No Abstract Available]Öğe Resveratrol prevents memory deficits caused by chronic unexpected mild stress in rats(Elsevier Science Bv, 2011) Utkan, Tijen; Özer, Cengiz; Göçmez, Semil Selcen; Gacar, Nejat; Arıcıoğlu, Feyza[No Abstract Available]
