DSpace Arşivi :: by Yazar "Ulaş, Turgay" değerine göre listeleniyor

Listeleniyor 1 - 1 / 1

Mesenchymal stem cell transfusion: Possible beneficial effects in COVID-19 patients
(Pergamon-Elsevier Science Ltd, 2021) Yigenoğlu, Tuğçe Nur; Başçı, Semih; Şahin, Derya; Ulaş, Turgay; Dal, Mehmet Sinan; Korkmaz, Serdal; Altuntaş, Fevzi; Turgut, Burhan
SARS-CoV-2 attaches to the angiotensin-converting enzyme 2 (ACE-2) receptor on human cells. The virus causes hypercytokinemia, capillary leak, pulmonary edema, acute respiratory distress syndrome, acute cardiac injury, and leads to death. Mesenchymal stem cells (MSCs) are ACE-2 negative cells; therefore, can escape from SARSCoV-2. MSCs prevent hypercytokinemia and help the resolution of the pulmonary edema and other damages occurred during the course of COVID-19. In addition, MSCs enhance the regeneration of the lung and other tissues affected by SARS-CoV-2. The case series reported beneficial effect of MSCs in COVID-19 treatment. However, there are some concerns about the safety of MSCs, particularly referring to the increased risk of disseminated intravascular coagulation, and thromboembolism due to the expression of TF/CD142. Prospective, randomized, large scale studies are needed to reveal the optimum dose, administration way, time, efficacy, and safety of MSCs in the COVID-19 treatment.