Yazar "Turgut, Nilda" seçeneğine göre listele
Listeleniyor 1 - 20 / 22
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe A database for screening and registering late onset Pompe disease in Turkey(Elsevier Ltd, 2018) Gokyigit, M.C.; Ekmekci, Hakan; Durmuş, H.; Karlı, N.; Köseoğlu, E.; Aysal, F.; Turgut, NildaThe aim of this study was to search for the frequency of late onset Pompe disease (LOPD) among patients who had a myopathy with unknown diagnosis registered in the pre-diagnostic part of a novel registry for LOPD within a collaborative study of neurologists working throughout Turkey. Included in the study were 350 patients older than 18 years who have a myopathic syndrome without a proven diagnosis by serum creatine kinase (CK) levels, electrodiagnostic studies, and/or muscle pathology, and/or genetic tests for myopathies other than LOPD. Acid alpha glucosidase (GAA) in dried blood spot was measured in each patient at two different university laboratories. LOPD was confirmed by mutation analysis in patients with decreased GAA levels from either both or one of the laboratories. Pre-diagnostic data, recorded by 45 investigators from 32 centers on 350 patients revealed low GAA levels in a total of 21 patients; from both laboratories in 6 and from either one of the laboratories in 15. Among them, genetic testing proved LOPD in 3 of 6 patients and 1 of 15 patients with decreased GAA levels from both or one of the laboratories respectively. Registry was transferred to Turkish Neurological Association after completion of the study for possible future use and development. Our collaborative study enabled collection of a considerable amount of data on the registry in a short time. GAA levels by dried blood spot even from two different laboratories in the same patient may not prove LOPD. LOPD seemed to be rarer in Turkey than in Europe. © 2017 Elsevier B.V.Öğe After stroke: Guidelines of Turkish Society of cerebrovascular diseases 2015(Turkish Society of Cerebrovascular Diseases, 2015) Bakar, M.; Özdağ, M.F.; Melek, I.; Uludüz, D.; Uzuner, G.T.; Armagan, O.; Uzuner, N.; Turgut, NildaIn this section, recommendation of recent management approaches about post-stroke complications such as sensorymotor function impairment, drops, epilepsy, depression and dementia will be offered.Öğe An epidemiologic investigation of amyotrophic lateral sclerosis in Thrace, Turkey, 2006-2010(Taylor & Francis Ltd, 2019) Turgut, Nilda; Saraçoğlu Varol, Gamze; Kat, Selahattin; Balcı, Kemal; Güldiken, Babürhan Feyzullah; Birgili, Özlem; Kabayel, LeventObjective: The aim of the study was to investigate the incidence and prevalence of amyotrophic lateral sclerosis (ALS) in Thrace, Turkey in a five-year time period (2006-2010). Methods: Study population included residents of three provinces (Edirne, Tekirdag, Kirklareli) in the Thrace region. Cases were ascertained from all of the neurologic centers and hospitals of these provinces. Demographic and clinical information was collected for each patient. Newly diagnosed ALS patients who are fulfilling the El Escorial revised diagnostic criteria were enrolled into the study. Results: We identified a total of 145 patients (93 males, 52 females). The mean age at diagnosis was 57.0 +/- 13.6. According to El Escorial criteria, 60.0% of the cases were definite ALS, 24.8% were probable, and 15.2% were possible ALS. Thirty-two cases were bulbar (22.1%), 113 cases (77.9%) were spinal onset. Mean time delay from onset to diagnosis was 12.0 +/- 11.2 months. Age-gender standardized incidence rates with reference to Turkey, USA 2008 census were 1.9 (95% confidence interval (CI), 1.8-2.1), 1.9 (95%CI, 1.8-2.2) for overall. There were 112 living ALS patients at the end of the study. Crude point prevalence was calculated as 7.3 per 100,000 population (95%CI, 5.9-8.7). Conclusions: This is the first study to provide fundamental data about demographic and clinical characteristics about ALS in Thrace region of Turkey. Incidence and prevalence of ALS in Thrace region of Turkey appear to be comparable with European countries.Öğe Bortezomib-induced peripheral neuropathy and neuronopathy in patients with multiple myeloma(Springer Heidelberg, 2013) Turgut, Nilda; Turgut, Burhan; Oran, Musatfa; Yetişyiğit, Tarkan; Alp, Recep; Ünal, A.[No Abstract Available]Öğe Calcitonin Gene Related Peptide Gene Polymorphism in Migraine Patients(Cambridge Univ Press, 2013) Güldiken, Babürhan Feyzullah; Sipahi, Tammam; Tekinarslan, Remziye; Kabayel, Levent; Özkan, Hülya; Ünlü, Ayhan; Turgut, NildaObjective: Calcitonin gene related peptide (CGRP), which has a vasodilator effect, is held responsible for neurogenic inflammation and vasodilatation of the cranial vessels in migraine pathophysiology. In this study, we investigated the association between alpha CGRP gene polymorphism (CALCA T-692C) and migraine. Material and Methods: One hundred and thirty-four female migraineurs and 96 healthy female cases were enrolled in the study. The patient group was further subdivided into migraine with and without aura groups. The CALCA T-692C gene polymorphism was identified using polymerase chain reaction (PCR) technique and restriction fragment length polymorphism (RFLP). Results: The genotype and allele frequencies of CALCA T-692C gene polymorphism did not differ between the migraine and control groups. Between the migraine with and without aura subgroups, there was no difference. No association was seen between the CALCA T-692C gene polymorphisms and migraine attack severity and frequency. Conclusion: Our study did not show any association between CALCA T-692C gene polymorphism and migraine.Öğe Comparison of Multiple Sclerosis Patients Using First Line Treatment vs Second Line Treatment(Sage Publications Ltd, 2020) Turgut, Nilda; Özcan, E.; Özden, O.; Karadeniz, S.; Gündoğdu, Aslı Aksoy; Altunan, Bengü[No Abstract Available]Öğe Comparison of VEP Parameters in NMOSD and MS Patients(Sage Publications Ltd, 2019) Turgut, Nilda; Altunan, Bengü; Gündoğdu, Aslı Aksoy[No Abstract Available]Öğe Differences in platelet-leukocyte aggregates among subtypes of acute cerebral ischemia(Elsevier, 2011) Turgut, Burhan; Turgut, Nilda; Çelik, Yahya; Tekgündüz, Emre; Pamuk, Gülsüm Emel; Demir, MuzafferBackground: Acute cerebral ischemia is caused by different pathophysiological mechanisms. The role of platelets and other blood cells can be different among the stroke subtypes. Methods: Seventy-two patients with acute ischemic cerebrovascular disease, including 31 patients with large vessel disease, 21 patients with cardioembolic disease, and 20 patients with small vessel disease, were evaluated. P-selectin (CD62P) expression and platelet leukocyte aggregates were measured with flow cytometry at the acute phase after the ischemic event. Markers were also measured in 37 control subjects. In all subjects, the serum high-sensitivity C-reactive protein (CRP) was also measured. Results: The platelet-monocyte aggregates (PMA) and platelet-granulocyte aggregates (PGA) in the large vessel disease group were higher than in control group (P=0.002, and P < 0.0001, respectively). The PMA and PGA in the small vessel disease group were also higher than in the control group (P=0.004 and P < 0.0001, respectively). In contrast, in the cardioembolic disease group, the PMA and PGA were not significantly different from the control group. CD62P expression was higher in all of the patient groups relative to the control group (P < 0.05 for all comparisons). Serum CRP levels were also higher in all of the patient groups than in the control group (P < 0.0001 for all comparisons). Conclusions: In contrast to large vessel and small vessel disease, it seems that platelet-leukocyte association does not play a crucial role in the pathogenesis of cardioembolic stroke. (C) 2011 Elsevier B.V. All rights reserved.Öğe Endothelial Nitric Oxide Synthase and Angiotensin Converting Enzyme Gene Polymorphisms in Migraine Patients(Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2013) Sipahi, Tammam; Güldiken, Babürhan Feyzullah; Kabayel, Levent; Palabıyık, Orkide; Özkan, Hülya; Okman Kılıç, Tülay; Turgut, NildaIntroduction: In this study, we investigated the association of migraine with the Variable Number of Tandem Repeats (VNTR), repeated as 27 base pair, gene polymorphism in intron 4 of the endothelial nitric oxide synthase (eNOS) and the insertion/deletion of angiotensin converting enzyme (ACE) gene polymorphisms. Methods: One hundred and five migraine and ninety seven healthy female control subjects were enrolled in the study. The patients were subdivided as migraine with aura and without aura, and the frequency and severity of migraine headaches were recorded. The eNOS VNTR (eNOS 4 a/b) and ACE insertion/deletion gene polymorphisms (ACE I/D) were assessed by polymerase chain reactions. Results: The allele and genotype frequencies of eNOS 4 a/b gene polymorphism showed no difference between the migraine and control groups. The genotypic distribution of the ACE I/D gene polymorphism in the migraine group significantly differed from that in the control group. The DD and ID genotype increased the risk of migraine as much as 2.571 (95% CI-1.138-5.811) and 4.453 (95% CI-2.006-9.883) compared to the II genotype. The same increased risk sustained for both genotypes in the migraine with aura subgroup, but only the ID genotype remained as the risk factor in the migraine without aura subgroup (OR-3.750, 95% CI-1.493-9.420). No association of gene polymorphisms with migraine frequency and severity was observed. Conclusion: Our findings support the relationship between migraine and the ACE I/D gene polymorphism. However, no association was found between migraine and the eNOS 4 a/b gene polymorphism.Öğe Epidemiologic investigation of amyotrophic lateral sclerosis in Trakya, Turkey, 2006-2010(Elsevier Science Bv, 2015) Turgut, Nilda; Saraçoğlu Varol, Gamze; Kat, Selahattin; Balcı, Kemal; Birgili, Özlem; Kabayel, Levent; Küçük, Mutlu[No Abstract Available]Öğe Gastrostomy in Hospitalized Patients with Acute Stroke: NoroTek Turkey Point Prevalence Study Subgroup Analysis(Galenos Publ House, 2022) Topçuoğlu, Mehmet Akif; Özdemir, Atilla Ozcan; Aykaç, Özlem; Milanoğlu, Ayşel; Gökçe, Mustafa; Bavli, Songül; Cabalar, Murat; Turgut, NildaObjective: Nutritional status assessment, dysphagia evaluation and enteral feeding decision are important determinants of prognosis in acute neurovascular diseases. Materials and Methods: NoroTek is a point prevalence study conducted with the participation of 87 hospitals spread across all health sub regions of Turkey conducted on 10-May-2018 (World Stroke Awareness Day). A total of 972 hospitalized neurovascular patients [female: 53%, age: 69 +/- 14; acute ischemic stroke in 845; intracerebral hematoma (ICH) in 119 and post-resuscitation encephalopathy (PRE) in 8] with complete data were included in this sub-study. Results: Gastrostomy was inserted in 10.7% of the patients with ischemic stroke, 10.1% of the patients with ICH and in 50% of the patients with PRE. Independent predictors of percutaneous endoscopic gastrostomy (PEG) administration were The National Institutes of Health Stroke Scale score at admission [exp (ss): 1.09 95% confidence interval (CI): 1.05-1.14, per point] in ischemic stroke; and mechanical ventilation in ischemic [exp (ss): 6.18 (95% CI: 3.16-12.09)] and hemorrhagic strokes [exp (ss): 26.48 (95% CI: 1.36-515.8)]. PEG was found to be a significant negative indicator of favorable (modified Rankin's scale score 0-2) functional outcome [exp (ss): 0.032 (95% CI: 0.004-0.251)] but not of in-hospital mortality [exp (ss): 1.731 (95% CI: 0.785-3.829)]. Nutritional and swallowing assessments were performed in approximately two-thirds of patients. Of the nutritional assessments 69% and 76% of dysphagia assessments were completed within the first 2 days. Tube feeding was performed in 39% of the patients. In 83.5% of them, tube was inserted in the first 2 days; 28% of the patients with feeding tube had PEG later. Conclusion: The NoroTek study provided the first reliable and large-scale data on key quality metrics of nutrition practice in acute stroke in Turkey. In terms of being economical and accurate it makes sense to use the point prevalence method.Öğe İNMEDE BEYİN ÖDEMİ VE KAFA İÇİ BASINÇ ARTIŞI: TÜRK BEYİN DAMAR HASTALIKLARI DERNEĞİ UZMAN GÖRÜŞÜ(2021) Ünal, Ali; Dora, Babür; Güngör, Levent; Polat, Murat; Doğan, Baki; Yılmaz, İbrahim Arda; Bingöl, Ayşe; Turgut, NildaBeyin ödemi inmeden sonra sık karşılaşılan bir sorundur. İntrakranial basınç artışı serebral perfüzyonu bozarak veserebral herniasyona yol açarak mortalite ve morbiditeyi artırır. İnme hastası takip eden nörologların, hangi inmedensonra beyin ödemi gelişeceğini kestirebilmesi, beyin ödemi gelişmemesi için önlemler alabilmesi, gelişirse intrakranialbasınç artışı ve serebral herniasyonu klinik ve radyolojik olarak tanıyabilmesi, ve önlenemezse beyin ödemi veintrakranial basınç artışını hızlı ve etkin şekilde tedavi edebilmesi gerekir. Bu uzman görüşü Türk Beyin DamarHastalıkları Derneği bünyesinde aktif olarak çalışan 60 uzmanın ortak görüşü ile hazırlanmış bir klinik rehberniteliğindedir.Öğe Kronik Obstrüktif Akciğer Hastalığı Olan Hastalarda Kognitif Fonksiyonların Değerlendirilmesi(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2018) Büyükkoyuncu Pekel, Nilüfer; Turgut, Nilda; Altıay, Gündeniz; Demir, Muzaffer; Turgut, Burhan; Erbaş, Hakan; Süt, NecdetObjective: Chronic obstructive pulmonary disease (COPD) is characterized with air flow limitation. Cognitive problems can appear in advanced stage of COPD. There is relationship between COPD and levels of homocystein (hcy) and total antioxidant capacity (TAC). There is also relationship between cognitive dysfunction and levels of hcy and TAC. We aimed evaluation of cognitive functions in patients with COPD, and demonstration of the relationship between cognitive function and hcy and TAC. Methods: Twenty-eight hypoxic (group 1), 28 non-hypoxic COPD patients (group 2) and 25 healthy people (control group, group 3) were included to study. Hcy and TAC levels were measured in all subjects. Cognitive functions were evaluated in all subjects with standardized mini mental test (SMMT), clock drawing test (CDT), Blessed orientation memory concentration test (BOMCT), Benton's facial recognition test (BFRT) and clinical dementia rating scale (CDRS). Results: Hcy levels were high in group 1 (p=0.004), TAC levels were high in group 1 and 2 (p=0.04). SMMT (p=0.000) and CDT values were low in group1 (p=0.000), CDRS values were high in group1 and 2 (p=0.000), BFRT values were low in group1 and 2 (p=0.000), BOMCT values were high in group1 (p=0.000). There were a correlation between TAC and SMMT (r=0.582, p=0.001) and CDRS (r=-0.384, p=0.044). Conclusions: We demonstrated presence of cognitive dysfunction in COPD patients. Patients with hypoxic had more profound cognitive dysfunction. In addition, we demonstrated a relationship between TAC and cognitive dysfunction.Öğe Management of complications and intensive care: Guidelines of Turkish Society of Cerebrovascular Diseases 2015(Turkish Society of Cerebrovascular Diseases, 2015) Güler, A.; Turgut, Nilda; Topaktas, S.; Topçuoglu, M.A.; Şirin, H.; Kocaman, A.S.; Uzuner, N.Clinical detoriation in ischemic stroke patients may develop because of several reasons. Deterioration may be caused by a recurrent brain infarction or cerebral hemorrhage. But increased intracranial pressure, infections especially pulmonary infections, embolic events, complications due to respiratory and feeding problems can cause worsening in clinical picture.Öğe Migren Hastalarında Endotelyal Nitrik Oksit Sentaz ve Anjiyotensin Dönüştürücü Enzim Gen Polimorfizmleri(2013) Sipahi, Tammam; Palabıyık, Orkide; Güldiken, Babürhan Feyzullah; Kabayel, Levent; Özkan, Hülya; Okman Kılıç, Tülay; Süt, Necdet Hilmi; Turgut, NildaGiriş: Bu çalışmada migren ile endotelyal nitrik oksit sentaz (eNOS) geni intron 4de, 27 bazlık tekrarlardan oluşan Ardışık Kopya Sayısı Tekrarları (VNTR) ve anjiyotensin dönüştürücü enzim (ADE) genindeki insersiyon/delesyon polimorfizmlerinin ilişkisi araştırıldı. Yöntemler: Çalışmaya 105 migren başağrısı olan ve 97 sağlıklı kadın birey alındı. Migren hastaları auralı ve aurasız olmak üzere iki gruba ayrılırken, migren atak sıklığı ve şiddeti kaydedildi. eNOS VNTR (eNOS 4a/b) ve ADE insersiyon/delesyon polimorfizmleri (ADE I/D) polimorfizmleri polimeraz zincir reaksiyonu yöntemi ile belirlendi. Bulgular: eNOS 4 a/b gen polimorfizminin alel ve genotip sıklıkları migren ile kontrol grubu arasında farklılık göstermedi. ADE I/D gen polimorfizminin migren grubunda genotipik dağılımı kontrol grubundan anlamlı olarak farklı bulundu. DD ve ID genotiplerinin II genotipine göre migren olasılığını 2,571 (%95 CI- 1,138-5,811) ile 4,453 (%95 CI- 2,006-9,883) oranında artırdığı saptandı. Aynı risk artışı auralı migren alt grubunda her iki genotip için sürerken, aurasız migren grubunda sadece ID genotipi için korundu (OR- 3,750, %95 CI- 1,493-9,420). Migren sıklığı ve şiddeti ile gen polimorfizmleri arasında ilişki gözlenmedi. Sonuç: Çalışmamız ADE I/D gen polimorfizmi ile migren ilişkisini desteklemiştir. Ancak eNOS 4 a/b gen polimorfizmi ile migren arasında ilişki gösterilememiştir. (Nöropsikiyatri Arflivi 2013; 50: 274-278)Öğe Revisiting the complex architecture of ALS in Turkey: Expanding genotypes, shared phenotypes, molecular networks, and a public variant database(Wiley, 2020) Tunca, Ceren; Şeker, Tuncay; Akçimen, Fulya; Coşkun, Cemre; Bayraktar, Elif; Palvadeau, Robin; Başak, A. Nazlı; Turgut, NildaThe last decade has proven that amyotrophic lateral sclerosis (ALS) is clinically and genetically heterogeneous, and that the genetic component in sporadic cases might be stronger than expected. This study investigates 1,200 patients to revisit ALS in the ethnically heterogeneous yet inbred Turkish population. Familial ALS (fALS) accounts for 20% of our cases. The rates of consanguinity are 30% in fALS and 23% in sporadic ALS (sALS). Major ALS genes explained the disease cause in only 35% of fALS, as compared with similar to 70% in Europe and North America. Whole exome sequencing resulted in a discovery rate of 42% (53/127). Whole genome analyses in 623 sALS cases and 142 population controls, sequenced within Project MinE, revealed well-established fALS gene variants, solidifying the concept of incomplete penetrance in ALS. Genome-wide association studies (GWAS) with whole genome sequencing data did not indicate a new risk locus. Coupling GWAS with a coexpression network of disease-associated candidates, points to a significant enrichment for cell cycle- and division-related genes. Within this network, literature text-mining highlightsDECR1, ATL1, HDAC2, GEMIN4, andHNRNPA3as important genes. Finally, information on ALS-related gene variants in the Turkish cohort sequenced within Project MinE was compiled in the GeNDAL variant browser (www.gendal.org).Öğe The comparison of vep parameters in neuromyelitis optica spectrum disorders and multiple sclerosis patients with acute optic neuritis(Istanbul Universitesi, 2020) Turgut, Nilda; Altunan, Bengü; Gündoğdu, AksoyIntroduction: Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are idiopathic, autoimmune, and central nervous system inflammatory diseases. The similarity in the clinical course of both diseases creates difficulties in the differential diagnosis. Pattern reversal visual evoked potentials (VEP) are used at this stage. This study aimed to investigate VEP’s role in the differential diagnosis of MS and NMOSD when the patients apply with acute optic neuritis. Method: The data of 15 relapsing-remitting MS patients (RRMS) and 10 NMOSD patients (1 seropositive patient) presenting with blurred vision and who were diagnosed with acute optic neuritis were retrospectively analyzed. Demographic, disease, and VEP characteristics of the patients were recorded. Results: According to retrospective data obtained from NMOSD patients, the mean P100 latency was 117.3 ± 12.3, and the mean amplitude was 6.1 ± 3.5. When the VEP characteristics obtained from 15 RRMS patients were evaluated, the P100 latency was 131.7 ± 17.3, and the mean P100 amplitude was 8.0 ± 3.0. P100 latency was significantly prolonged in the RRMS group than the NMOSD group, and amplitude was significantly lower in the NMOSD group than the RRMS group. Discussion: Differentiating NMOSD patients with optic neuritis from MS in the early period is very important for preventing permanent visual damage, initiating appropriate treatment, planning treatment, and predicting prognosis. VEP findings in early-stage acute optic neuritis can be used to differentiate clinically challenging both seropositive and seronegative NMOSD patients from patients with MS. © 2020, Istanbul Universitesi. All rights reserved.Öğe The effect of pelvic floor exercise program on incontinence and sexual dysfunction in multiple sclerosis patients(Springer Science and Business Media B.V., 2021) Altunan, Bengü; Gündoğdu, Aslı Aksoy; Kurtoğlu Özçağlayan, Tuğba İlkem; Ünal, A.; Turgut, NildaPurpose: Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system that involves different neurological areas. In addition to lower urinary tract symptoms (LUTS), sexual dysfunction (SD), and psychopathological effects, MS sometimes seriously impairs the quality of life (QoL). We hypothesize that the pelvic floor exercise program (PFEP) could improve bladder, sexual function, depression, and QoL in MS patients. Methods: Patients diagnosed with MS completed the Incontinence Questionnaire Short Form (ICIQ-SF), the Beck Depression Inventory (BDI), the Multiple Sclerosis Quality of Life-54 (MSQoL-54) questionnaire, and either the Female Sexual Function Index (FSFI) or the Sexual Health Inventory for Men (SHIM). Maximum bladder volumes (MBV) and post-voiding residual (PVR) volumes were measured using ultrasonography. The patients who regularly completed the PFEP for 12 weeks were asked to fill out the questionnaires again, and their MBV and PVR were remeasured. Results: Seventy-two patients with relapsing–remitting multiple sclerosis (RRMS) were included in the study. Forty-two (58.3%) RRMS patients reached the end of the study. The patients’ post-PFEP average MBV statistically increased (p = 0.01). In contrast, no statistically significant difference was found in the PVR (p = 0.2). After exercise, the FSFI values in women increased (p = 0.02), and ICIQ-SF and BDI values in all the RRMS patients statistically decreased (p = 0.004, p = 0.01, respectively), but there was no improvement in the MSQoL-54 score (p > 0.05). Conclusion: PFEP, which causes a reduction in LUTS by enhancing the MBV of RRMS patients, can be seen as an investment in the future in terms of reducing depression in MS patients and preventing or delaying SD in women. © 2021, The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature.Öğe The effect of social support, depression, and illness perception on treatment adherence in patients with multiple sclerosis(Marmara Univ, Fac Medicine, 2022) Girgin, Derya; Tosun, Zeynep; Turgut, Nilda; Güler, SibelObjective: This study was planned to determine the treatment adherence levels of multiple sclerosis (MS) patients and the factors affecting treatment adherence. Patients and Methods: This descriptive and cross-sectional study was conducted with 211 people with MS. Data for this study was obtained through face-to-face interviews with MS patients who presented at the neurology outpatient clinics of two university hospitals between April and October 2018. The Morisky, Green, and Levine Adherence Scale, Beck Depression Inventory, Multidimensional Perceived Social Support Scale, and the Illness Perception Scale were used in data collection. Results: The mean age of the sample was 40.03 +/- 10.82, and 70.1% were female. Treatment adherence was not good in half of the patients (51.7%). Patients with good adherence were found to have higher Multidimensional Perceived Social Support Scale scores (p<0.01) and lower Beck Depression Inventory scores (p<0.01). The illness perceptions of the patients regarding MS did not affect treatment adherence (p>0.05). Conclusion: Treatment adherence was insufficient in half of the MS patients. According to our findings, ensuring more cooperation with the families of patients, which constitute the strongest source of social support, increasing treatment adherence can be suggested as well as screening patients with regard to depressive symptomology during follow-up.Öğe Tip 1 Diabetes Mellituslu Çocuklarda Uyarılmış Potansiyellerin Eş Zamanlı Kan Şekeri, Serum ve Hu cre İ çi Magnezyum Du zeyleri ve Glikozillenmiş Hemoglobin ile İ lişkisi(2020) Karal, Yasemin; Karasalihoğlu, Serap Tevhide; Turgut, Nilda; Öner, Cevat Naci; Tütüncüler, FilizTip I Diabetes Mellitus çocukluk çağının ciddi komplikasyonlar ile seyreden kronik metabolik hastalıklarından biridir. Buçalışmanın amacı Tip I Diabetes Mellituslu çocuklarda erken dönemde santral sinir sistemi tutulumunun uyarılmış potansiyelleraracılığıyla değerlendirilmesi ve metabolik değişikliklerle ilişkisini saptamaktır. Çalışmaya 5-14 yaş arasında 31 Tip I DiabetesMellituslu ve aynı yaş ve cinsiyette 35 sağlam çocuk alındı. Olgulardan 8 saat açlık sonrası HbA1c, kan şekeri, serum ve hücre içimagnezyum düzeyleri için kan örnekleri alındı. Tüm olguların otoskopik muayeneleri, işitme testleri ve uyarılmış potansiyelölçümleri yapıldı. Gruplar metabolik parametreler, diabet süresi ve uyarılmış potansiyeller açısından karşılaştırıldı. Çalışmagrubunun HbA1c ve kan şekeri değerleri kontrol grubuna göre anlamlı düzeyde yüksek, serum Mg değerleri istatistiksel olarakanlamlı oranda düşük saptandı (p<0.001) Diabetik grubun görsel uyarılmış potansiyelleri ve işitsel uyarılmış potansiyellerininanlamlı oranda bozulduğu saptandı (p<0.05). Her iki grup arasında duyusal uyarılmış potansiyel değerlerinde belirgin farklılıkgözlenmedi (p>0.05). Diabetik gruptaki tüm bu etkilenmelerin serum ve hücre içi magnezyumu, eş zamanlı kan şekeri, diabet süresive HbA1c düzeyleri ile ilişkili olduğu bulundu (p<0.05). Çalışmamızda diabette santral sinir sistemi tutulumu uyarılmışpotansiyeller aracılığı ile gösterilebilen en erken bulgu olabileceği saptanmıştır. Bu etkilenmenin nedenleri arasında eş zamanlı kanşekeri ve diabetin süresi kadar glikozillenmiş hemoglobin, serum ve hücre içi magnezyum düzeyleri önemli de önemli yertutmaktadır. Bu nedenle uyarılmış potansiyeller ve kan magnezyum düzeyi ölçümlerinin HbA1c, kan şekeri ölçümlerinde olduğugibi diabetin rutin takip programına alınması yararlı olacaktır.
