Yazar "Tezcan, Mehmet Engin" seçeneğine göre listele

Listeleniyor 1 - 6 / 6
  • Küçük Resim
    Öğe
    Enthesitis may be one of the signs of severe disease in familial Mediterranean fever
    (Springer London Ltd, 2021) Şen, Nesrin; Yılmaz, Mesut; Mercan, Rıdvan; Volkan, Ömür; Yılmaz Öner, Sibel; Tükel, Ezgi; Tezcan, Mehmet Engin
    Objective Familial Mediterranean fever (FMF) is an auto-inflammatory disease that is also characterized with some of the common musculoskeletal features of spondyloarthritis (SpA). Enthesitis is the hallmark of SpA. Recently, it was postulated that exertional leg pain is a possible sign of lower extremity enthesitis associated with FMF severity. In this study, we have evaluated the association between the enthesitis, enthesitis score and disease severity in FMF patients. Methods We enrolled 238 FMF patients that fulfilled the modified Tel-Hashomer criteria. We assessed the presence of enthesitis at the Maastricht Ankylosing Spondylitis Enthesitis Score (MASES) defined sites with standard palpation method. Then, FMF patients dichotomised two groups as enthesitis group and controls. Herein, we evaluated the enthesis extensity with MASES. FMF disease severity was determined via the international severity scoring system for FMF (ISSF). Firstly, we have compared demographic properties, disease-related features and ISSF scores of the groups. Then, we have correlated ISSF with MASES in enthesitis group. Results We showed that 54 (22.6%) of 238 patients had enthesitis. The demographic features were similar between the groups. The enthesitis group had higher ISSF scores (p < 0.001); higher frequency of fever (p = 0.004), exertional leg pain (p < 0.001), myalgia (p < 0.001) and arthritis (p = 0.01); and more intense, widespread, frequent and longer attacks compared with controls. Moreover, there was a weak correlation between ISSF and MASES in the patients with enthesitis. Conclusion Enthesitis may be a sign of more severe FMF phenotype and frequently associated with other musculoskeletal manifestations resemble SpA.
  • Küçük Resim
    Öğe
    Familial mediterranean fever patients may have unmet needs for the treatments of exertional leg pain and enthesitis
    (Elsevier Espana Slu, 2022) Tezcan, Mehmet Engin; Volkan, Ömür; Mercan, Rıdvan; Şen, Nesrin; Yılmaz-Öner, Sibel
    Introduction: Exertional leg pain (ELP) and enthesitis are musculoskeletal findings in familial Mediterranean fever (FMF). They are not accepted as principal treatment targets. In this study, we assessed the effectiveness of treatments on ELP and enthesitis. Material and methods: We have included 218 FMF patients to the study. We retrospectively compared the FMF attacks' frequency, duration and intensity (FMF attack VAS score) and levels of ELP VAS and enthesitis VAS scores between pre-treatment stage and while patients were on treatment at the last visit. Results: Forty-nine (22.5%) and 52 (23.9%) of the patients had enthesitis and ELP respectively. All patients were on colchicine treatment. Serositis attacks respond the treatments significantly. Moreover, both ELP VAS scores (p = 0.002) and enthesis VAS scores (p = 0.17) were improved with treatment. But only improvement in ELP VAS scores was significant. Conclusion: FMF treatments had favourable effect on ELP and enthesitis in FMF patients. However, the response rates would be inadequate. Therefore, there would be unmet need for treatment of both conditions.(c) 2021 Elsevier Espana, S.L.U. and Sociedad Espanola de Reumatologia yColegio Mexicano de Reumatologia. All rights reserve.
  • Küçük Resim
    Öğe
    Familial Mediterranean Fever Patients may have Unmet Needs for the Treatments of Exertional Leg Pain and Enthesitis
    (Ediciones Doyma, S.L., 2021) Tezcan, Mehmet Engin; Volkan, Ömür; Mercan, Rıdvan; Şen, Nesrin; Yılmaz Öner, Sibel
    Introduction: Exertional leg pain (ELP) and enthesitis are musculoskeletal findings in familial Mediterranean fever (FMF). They are not accepted as principal treatment targets. In this study, we assessed the effectiveness of treatments on ELP and enthesitis. Material and methods: We have included 218 FMF patients to the study. We retrospectively compared the FMF attacks’ frequency, duration and intensity (FMF attack VAS score) and levels of ELP VAS and enthesitis VAS scores between pre-treatment stage and while patients were on treatment at the last visit. Results: Forty-nine (22.5%) and 52 (23.9%) of the patients had enthesitis and ELP respectively. All patients were on colchicine treatment. Serositis attacks respond the treatments significantly. Moreover, both ELP VAS scores (p = 0.002) and enthesis VAS scores (p = 0.17) were improved with treatment. But only improvement in ELP VAS scores was significant. Conclusion: FMF treatments had favourable effect on ELP and enthesitis in FMF patients. However, the response rates would be inadequate. Therefore, there would be unmet need for treatment of both conditions. © 2021 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología
  • Küçük Resim Yok
    Öğe
    Infection frequency may not increase in Familial Mediterranean fever
    (Galenos Publishing House, 2024) Şen, Nesrin; Mercan, Rıdvan; Volkan, Ömür; Bayar, Esra; Yılmaz-öner, Sibel; Tezcan, Mehmet Engin
    Objective: To the best of our knowledge, there is no study evaluating the infectious features of Familial Mediterranean fever (FMF) in the literature. Here, we tested two hypotheses: infection is more common in FMF and FMF severity and infection may be linked. Methods: We included three groups: FMF (363 patients), spondyloarthropathy (SpA-patients) (112 patients) and control (121 patients). We screened participants for infection characteristics in the last year with a pre-approved and validated questionnaire. Firstly, we compared infection rates, frequency of infection types, and infection severity within groups. We then evaluated the factors associated with infection in FMF. Results: We found that infection rates were similar in FMF, SpA-patients and controls. However, admission to the infection outpatient clinic was more common in FMF (p=0.001) and the duration of workforce loss due to infection was longer in FMF than controls (p=0.002). Furthermore, FMF-patients with infection had higher disease severity (p=0.004), high acute phase reactants between attacks (p=0.006) and more site involvement during attacks (p<0.001). In multivariate analyses, the latter was found to be significant (p=0.003). Conclusion: We discovered no increase in the infection rate of FMF patients. Patients with infections, on the other hand, may have more severe FMF. © 2024 The Author. Published by Galenos Publishing House on behalf of Turkish Society for Rheumatology.
  • Küçük Resim
    Öğe
    Psoriasis and family history of psoriasis may not affect disease severity of rheumatoid arthritis
    (Pagepress Publ, 2021) Şen, Nesrin; Mercan, Rıdvan; Geçmez, G.; Ediz, B.; Volkan, Ömür; Yılmaz Öner, Sibel; Tezcan, Mehmet Engin
    The incidence of psoriasis in patients with rheumatoid arthritis (RA) is higher than in the general population. In addition, psoriasis may negatively affect the severity of rheumatological diseases in patients with autoinflammatory or autoimmune diseases. In this study, we evaluated the effect of psoriasis or a family history of psoriasis on the characteristics of RA. This is a cross-sectional study. We included 737 RA patients who met the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) RA Classification Criteria, but did not meet the CASPAR psoriatic arthritis criteria. Subsequently, we compared disease activity, the need for biologic therapy, the number of conventional synthetic disease-modifying anti-rheumatic drugs taken, the frequency of erosive disease and extra-articular involvement, glucocorticoid doses and the Stanford Health Assessment Questionnaire scores between patients with and without a history of psoriasis, and patients with and without a family history of psoriasis. Thirteen (1.8%) patients had psoriasis, while 58 (7.9%) had a family history of psoriasis in first- or second-degree relatives. All outcome parameters were found to be similar between the groups. We show that concomitant psoriasis has no effect on the evaluated disease characteristics of RA.
  • Küçük Resim
    Öğe
    Romatoloji Perspektifinden COVID-19
    (2020) Tezcan, Mehmet Engin; Mercan, Rıdvan
    Korona virüs hastalığı-19 (COVID-19), Dünya Sağlık Örgütü tarafından 11 Mart 2020'de pandemi olarak tanımlanmıştır. SARS-CoV-2, COVID-19'a neden olan ve yeni gelişen insan korona virüsüdür. Bu virüs, ilk olarak Aralık 2019'da Çin'in Wuhan şehrinde tespit edilmiştir. COVID-19, hafif hastalıktan, şiddetli solunum yetmezliğine kadar farklı klinik spektrumunda ortaya çıkabilir. Şu an COVID-19hastalarının yönetiminde kesin bir fikir birliği yoktur. Bununla birlikte, diğer hastalıklar için önerilen bazı ilaçların, bu enfeksiyonun tedavisinde potansiyel olarak etkili olabileceği gösterilmiştir. Bu derlemenin amacı, COVID-19 pandemisinde romatizmal hastalıkları, savunma sistemi etkileyici ilaç kullanan hastaların yönetimini ve savunma sistemini baskılayıcı ilaçların COVID-19 tedavisinde kullanımı dahil olmak üzere romatoloji ile ilgili yönlerini gözden geçirmektir.