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    Bibliometric analysis of most cited Peyronie's disease and its management publications
    (Frontiers Media Sa, 2024) Sahin, Mehmet Fatih; Dogan, Cagri; Akgul, Murat; Yazici, Cenk Murat; Seramet, Serkan; Dayisoylu, Hulusi Sitki
    Introduction Peyronie's disease (PD) is a common urologic illness, motivating numerous scientific investigations and publications. Scientific publications have more authors each year. A bibliometric review of the PD literature might help urologists and sexual medicine professionals comprehend publication tendencies in this subject. The current study was aimed at presenting a bibliometric analysis of PD, which is one of the important and trending subjects of andrology.Methods On January 5, 2023, Web of Science scanned documents with the terms Peyronie's disease Peyronie's disease treatment, Peyronie's disease management, Peyronie's disease surgery and Peyronie's disease injection from 1975 through 2023. Titles, years, authors, citations, citation indices, journal names, authors' countries of origin, article categories, and funding sources were recorded.Results Clinical Efficacy, Safety and Tolerability of Collagenase Clostridium Histolyticum for the Treatment of Peyronie Disease in 2 Large Double-Blind, Randomized, Placebo Controlled Phase 3 Studies has the most citations and citation index. Most of the T100 articles were published in 2020, primarily in the Journal of Urology. These articles mainly focused on treatment, especially surgeries. All of these articles were in English, and the vast majority of them were by authors from the US who were most frequently collaborated with by other authors.Conclusion This research analyzed the top 100 PD studies. This research focused on pathophysiology, innovative surgical procedures, and new approaches of PD. It also recommended bigger databases and more financing for research.
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    Still Using Only ChatGPT? The Comparison of Five Different Artificial Intelligence Chatbots' Answers to the Most Common Questions About Kidney Stones
    (Mary Ann Liebert, Inc, 2024) Sahin, Mehmet Fatih; Topkac, Erdem Can; Dogan, Cagri; Seramet, Serkan; Ozcan, Ridvan; Akgul, Murat; Yazici, Cenk Murat
    Objective: To evaluate and compare the quality and comprehensibility of answers produced by five distinct artificial intelligence (AI) chatbots-GPT-4, Claude, Mistral, Google PaLM, and Grok-in response to the most frequently searched questions about kidney stones (KS).Materials and Methods: Google Trends facilitated the identification of pertinent terms related to KS. Each AI chatbot was provided with a unique sequence of 25 commonly searched phrases as input. The responses were assessed using DISCERN, the Patient Education Materials Assessment Tool for Printable Materials (PEMAT-P), the Flesch-Kincaid Grade Level (FKGL), and the Flesch-Kincaid Reading Ease (FKRE) criteria.Results: The three most frequently searched terms were stone in kidney, kidney stone pain, and kidney pain. Nepal, India, and Trinidad and Tobago were the countries that performed the most searches in KS. None of the AI chatbots attained the requisite level of comprehensibility. Grok demonstrated the highest FKRE (55.6 +/- 7.1) and lowest FKGL (10.0 +/- 1.1) ratings (p = 0.001), whereas Claude outperformed the other chatbots in its DISCERN scores (47.6 +/- 1.2) (p = 0.001). PEMAT-P understandability was the lowest in GPT-4 (53.2 +/- 2.0), and actionability was the highest in Claude (61.8 +/- 3.5) (p = 0.001).Conclusion: GPT-4 had the most complex language structure of the five chatbots, making it the most difficult to read and comprehend, whereas Grok was the simplest. Claude had the best KS text quality. Chatbot technology can improve healthcare material and make it easier to grasp.
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    The Results of Urodynamics and Pressure Flow Study of Patients with Neurological Disease in a Single Center for 12 Years: Neurogenic Bladder Etiology
    (Galenos Publ House, 2023) Dogan, Cagri; Akgul, Murat; Yazici, Cenk Murat; Malak, Arzu; Altin, Enes; Seramet, Serkan; Dayisoylu, Hulusi Sitki
    Aim: Generally, urodynamic-pressure flow study (U-PFS) is performed on patients with lower urinary tract symptoms (LUTS) for verifying the diagnosis and evaluating the rate of response for treatment. The aim of the study was to assess the results of the U-PFS of patients according to the etiology of neurological disorders. Materials and Methods: The data of 2,489 patients who underwent U-PFS in our clinic between 2010-2022 were analyzed retrospectively. A total of 535 patients with LUTS and neurogenic disorder were included in the study. Patients were divided into subgroups according to their diagnosis. The patient's age, gender, and U-PFS data (sensation of first urine, maximum cystometric capacity (MSC), maximum detrusor pressures in the filling phase, presence of urgency, and bladder compliance status) were evaluated and compared according to neurological disorders. Results: Cervical and lumbar disc disorder was found in 204 (38.1%) patients, multiple sclerosis (MS) in 103 (19.2%), and cerebrovascular incidents in 74 (13.8%) patients (SVI), spinal cord injury in 48 (8.9%), polyneuropathy in 43 (8.0%), Parkinson's disease (PD) in 30 (5.6%), diabetic neuropathy in 18 (3.4%), and operated spine bifida (oSB) in 15 (2.8%) was detected. Detrusor pressures in the filling phase were compared according to neurological disorders, and detrusor pressures were statistically significantly higher in patients with oSB and PD (52.66 +/- 40.78 mmHg; 45.30 +/- 34.43 mmHg, respectively; p<0.001). When the MSCs were compared, it was observed that the bladder capacity was significantly lower in PD and ASD patients, whereas bladder capacity was relatively increased in lomber and servical disc disorder, spinal cord injury and polyneuropathy patients (respectively 308.71 +/- 190.25 mL, 264.81 +/- 140.25 mL, 491.90 +/- 167.49, 474.52 +/- 182.92, 447.67 +/- 168.03, p<0.001). Conclusion: These specific patient groups (oSB and spinal cord injury) are hazardous groups for the development of end-stage kidney failure. Clinicians should take into consideration that patients and their relatives have to be informed about possible long-term complications.
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    Urodynamic Findings of the Patients with Parkinson's Disease: A Single Tertiary Center Results
    (Duzce Univ, Fac Medicine, 2024) Sahin, Mehmet Fatih; Akgul, Murat; Dogan, Cagri; Malak, Arzu; Seramet, Serkan; Yazici, Cenk Murat
    Objective: In Parkinson's disease (PD), lower urinary tract symptoms (LUTS) are common with a prevalence ranging from 25% to 57%. Patients who are resistant to medical treatment for LUTS may require urodynamic examination and pressure flow study (UDPFS) to better comprehend the bladder's dynamics. To be able to understand the pathophysiology of LUTS, UD-PFS examinations should be performed. In this study, the demographics and clinical properties of PD patients were presented along with their UDPFS examinations. Materials and Methods: The data of 155 patients with PD followed up between 20102020 were retrospectively analyzed. UD-PFS was applied to 42 PD patients resistant to medical treatment of LUTS. Patients' demographic and clinical data with their UD-PFS findings were investigated separately. Results: Twenty-eight of the patients underwent UD-PFS were male, and 14 were female. In UD, the first urinary sensation was 86.00 +/- 68.77cc, and the maximum cystometric capacity was 322.07 +/- 194.25cc. Sixteen patients had a hypo -compliant bladder, 25 (59.5%) had a normo-compliant bladder. In PFS, Q max and peak detrusor pressure during voiding were 12.72 +/- 10.08 mL/sec and 43.93 +/- 15.56 cm-H2O, respectively. Stress -type urinary incontinence was detected in 6 (15%) of the patients. When evaluating the detrusor activity, neurogenic detrusor overactivity was observed in 18 (44%) patients, detrusor areflexia in 8 (19%) and normal UD-PFS in 16 (22%) patients. Conclusions: The majority of the PD patients presented with neurogenic detrusor overactivity accompanied by diminished bladder capacity and hypersensitivity. In the selected PD patients who are resistant to medical treatment with LUTS clinics, UD-PFS provides useful scientific information about the LUTS clinics of patients and may be helpful in treatment management.
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    Which current chatbot is more competent in urological theoretical knowledge? A comparative analysis by the European board of urology in-service assessment
    (Springer, 2025) Sahin, Mehmet Fatih; Dogan, Cagri; Topkac, Erdem Can; Seramet, Serkan; Tuncer, Furkan Batuhan; Yazici, Cenk Murat
    IntroductionThe European Board of Urology (EBU) In-Service Assessment (ISA) test evaluates urologists' knowledge and interpretation. Artificial Intelligence (AI) chatbots are being used widely by physicians for theoretical information. This research compares five existing chatbots' test performances and questions' knowledge and interpretation.Materials and methodsGPT-4o, Copilot Pro, Gemini Advanced, Claude 3.5, and Sonar Huge chatbots solved 596 questions in 6 exams between 2017 and 2022. The questions were divided into two categories: questions that measure knowledge and require data interpretation. The chatbots' exam performances were compared.ResultsOverall, all chatbots except Claude 3.5 passed the examinations with a percentage of 60% overall score. Copilot Pro scored best, and Claude 3.5's score difference was significant (71.6% vs. 56.2%, p = 0.001). When a total of 444 knowledge and 152 analysis questions were compared, Copilot Pro offered the greatest percentage of information, whereas Claude 3.5 provided the least (72.1% vs. 57.4%, p = 0.001). This was also true for analytical skills (70.4% vs. 52.6%, p = 0.019).ConclusionsFour out of five chatbots passed the exams, achieving scores exceeding 60%, while only one did not pass the EBU examination. Copilot Pro performed best in EBU ISA examinations, whereas Claude 3.5 performed worst. Chatbots scored worse on analysis than knowledge questions. Thus, although existing chatbots are successful in terms of theoretical knowledge, their competence in analyzing the questions is questionable.