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Öğe Discussion on the Artificial Intelligence (AI) Tools Usage in the Scientific World(Pera Yayincilik Hizmetleri, 2023) Ozkan, Mazhar; Sasani, Hadi[Abstract Not Available]Öğe Investigation of the Effect of Tinnitus and Hearing Loss on Hippocampus Volume(2024) Sasani, Hadi; Ozkan, Mazhar; Ersozlu, TolgaObjective: This study aims to compare hippocampal changes with a correlation of audiological testing results in patients suffering from tinnitus. Methods: Patients diagnosed with tinnitus in the university hospital between February 2021 and March 2022 were prospectively included in the study by performing magnetic resonance imaging. The volume was determined by manually tracing the hippocampus’ margins on the images using the Vitrea2® workstation (Canon Medical Systems Vital Images, Minnesota, USA). Statistics were used to assess the correlation between the parameters of the hearing test. Results: The distribution of the patient group (21 males, 19 females) and control group (15 males, 15 females) was uniform, and the mean ages of the two groups were 50.23±12.09 and 32.30±7.97, respectively. Significant statistical differences existed in the mean ages of the groups (p<0.05). Bilateral hippocampal volumes, right bone, and air conduction all differed significantly (p<0.05). The median values in the patient group were as follows: right HC 2620 mm3 (range 1600-3610), left HC 2450 mm3 (range 1610-3990), right air conduction 20 dB (range 10-61), left air 21 dB (range 11-65), and right bone 13.5 dB (range 8-49). Age was positively correlated with bilateral measurements of air and bone hearing levels (p 0.05; right air r=0.513, right bone r=0.438, left air r=0.589, left bone r=0.487). Between the 30-39 and 60-69 age groups, there was a significant difference in bone and air conduction levels (p<0.05). Conclusion: In this study, it was found that the hippocampus volumes of healthy hearing people with tinnitus complaints were significantly higher in MRI examinations compared to the control group. In addition, in cases of tinnitus accompanied by bone conduction hearing loss, hippocampus volumes were found to be less than those of tinnitus alone, but not less than in the control group. It is suggested that chronic acoustic stimulation caused by tinnitus causes an increase in hippocampus volume and that problems in sensorineural integrity prevent this increase.Öğe Investigation of the Effect of Tinnitus and Hearing Loss on Hippocampus Volume(Pera Yayincilik Hizmetleri, 2024) Sasani, Hadi; Ozkan, Mazhar; Ersozlu, TolgaObjective: This study aims to compare hippocampal changes with a correlation of audiological testing results in patients suffering from tinnitus. Methods: Patients diagnosed with tinnitus in the university hospital between February 2021 and March 2022 were prospectively included in the study by performing magnetic resonance imaging. The volume was determined by manually tracing the hippocampus' margins on the images using the Vitrea2 (R) workstation (Canon Medical Systems Vital Images, Minnesota, USA). Statistics were used to assess the correlation between the parameters of the hearing test. Results: The distribution of the patient group (21 males, 19 females) and control group (15 males, 15 females) was uniform, and the mean ages of the two groups were 50.23 +/- 12.09 and 32.30 +/- 7.97, respectively. Significant statistical differences existed in the mean ages of the groups (p<0.05). Bilateral hippocampal volumes, right bone, and air conduction all differed significantly (p<0.05). The median values in the patient group were as follows: right HC 2620 mm3 (range 1600-3610), left HC 2450 mm3 (range 1610-3990), right air conduction 20 dB (range 10-61), left air 21 dB (range 11-65), and right bone 13.5 dB (range 8-49). Age was positively correlated with bilateral measurements of air and bone hearing levels (p 0.05; right air r=0.513, right bone r=0.438, left air r=0.589, left bone r=0.487). Between the 30-39 and 60-69 age groups, there was a significant difference in bone and air conduction levels (p<0.05). Conclusion: In this study, it was found that the hippocampus volumes of healthy hearing people with tinnitus complaints were significantly higher in MRI examinations compared to the control group. In addition, in cases of tinnitus accompanied by bone conduction hearing loss, hippocampus volumes were found to be less than those of tinnitus alone, but not less than in the control group. It is suggested that chronic acoustic stimulation caused by tinnitus causes an increase in hippocampus volume and that problems in sensorineural integrity prevent this increase.Öğe Lymphatic vessels accompanying dorsal and basal dural sinuses in the human brain(Elsevier, 2023) Cavdar, Safiye; Kose, Busra; Altinoz, Damlasu; Soyler, Gizem; Cingoz, Ahmet; Gurses, Ilke Ali; Ozkan, MazharRecent investigations showed the presence of meningeal lymphatic vessels (mLVs) along the superior sagittal and transverse dural sinuses which drain both fluid and immune cells from the cerebrospinal fluid (CSF) to the deep cervical lymph nodes. This study uses immunohistochemistry (IHC) and the Western Blot technique to show the presence of mLV accompanying the dorsal (superior sagittal, inferior sagittal, transverse, sigmoid, and straight) and basal (cavernous, sphenoparietal, superior, and inferior petrosal) dural sinuses in the human brain. Samples for IHC were obtained from dorsal and basal meningeal dural sinuses of 3 human cadavers and 3 autopsies. Routine histological techniques were carried out for the specimens. Podoplanin (PDPN, lymphatic vessel endothelial cell marker) and CD31 (vascular endothelial cell marker) IHC staining were applied to the 5 mu m thick paraffin sections. Furthermore, PDPN and CD31 protein expressions were evaluated using Western Blot to the tissue samples from the same regions of 4 autopsies. Two consecutive sections from each sinus were PDPN, and CD31 was stained to differentiate blood vessels (BV) from mLV. The IHC staining showed the presence of mLVs accompanying both dorsal and basal dural sinuses. The mLVs accompanying the dorsal dural sinuses had a larger dimensions range compared to the basal dural sinuses. However, the number of mLVs along the basal dural sinuses was more than the mLVs along the dorsal ones. Further, fluid channels were closely localized to the mLV, with varying diameters and densities. Western Blotting technique showed the presence of PDPN expression in both dorsal and basal dural sinus samples. The knowledge of the presence of mLV along both dorsal and basal dural sinuses in humans can increase the understanding of how mLV contributes to the brain lymphatic circulation and may help understand the neuropathophysiological processes of various neurological diseases.Öğe Predicting functional movement capacity in adults: the effect of range of motion and isometric strength(Bmc, 2024) Ozkan, Mazhar; Canli, Umut; Alwhaibi, Reem; Ustamer, Kubra; Karacam, Aydin; Orhan, Bekir Erhan; Bohn, LucimereThe aim of the study was to determine the role of isometric strength and range of motion in predicting Functional Movement Screen (FMS) scores of adults. A total of 120 participants (age = 34.62 +/- 11.82 years; height = 170.56 +/- 9.63 cm; weight = 73.62 +/- 15.39 kg) volunteered to participate in the study. Anthropometric measurements were performed, including height, body weight, muscle mass, and body fat. Following this, the ranges of motion of the shoulder, hip, knee, and ankle joints were measured sequentially. Isometric strength and FMS tests were then performed. Hip extension isometric strength explained 23% of the variation in FMStotal. The common effect of knee flexion, shoulder flexion, and dorsiflexion joint range of motion explained 34% of the change in FMStotal (F ((3-116)) = 20.375, p < 0.001). A significant relationship (R = 0.658, R-2 = 0.413) was found between hip extension isometric strength, knee flexion, shoulder flexion, and dorsiflexion range of motion and FMStotal (F ((4-115)) = 21.952, p < 0.001). The common effect of all these variables explains 43% of the change in FMStotal. The results indicate that the FMS test scores, which are utilized to evaluate the risk of injury in sedentary adults, can be significantly predicted by the effect of hip extension isometric strength and parameters related to knee flexion, shoulder flexion, and dorsiflexion joint range of motion. At this time, it is advised that range of motion and isometric strength be taken into account when determining a person's functional movement capacity.Öğe The Change of Oral Presentations of National Anatomy Congresses Over the Years(Pera Yayincilik Hizmetleri, 2023) Ozkan, Mazhar; Dincel, Yasar MahsutIntroduction: In this study, it is aimed to examine the characteristics and publication rates of oral presentations presented in national congresses. Methods: The data about the oral presentations in national anatomy congresses (from 2016 to 2021), including the number of contributing institutions, the institutions that contributed the most oral presentations each year, and the publication rates of the oral presentations in the journals scanned in different indexes. In the study, the titles and the keywords were scanned using Google Scholar and Web of Science, and journal index details were noted. Results: Of the national congresses we examined in our study, the most oral presentations (193) were the congress in 2019 and the least oral presentations (47) were the congress in 2017. The publication rate of oral presentations was highest in the papers of the congress in 2016 (42%) and at least in the papers of the congress in 2019 (13%). None of the oral presentations in the last congress held in 2021 were published until the time of our study. Large proportions (34%) of the papers that are accepted as oral presentations and published are radiological studies. 70% of the publications were published in journals indexed in Web of Science. Conclusion: For both new and senior academics, congresses offer a useful and distinctive setting. Congress papers showcase the scientific opportunities and interests of various universities while also providing opportunities for collaboration. Attendance at a conference is significantly influenced by its location, timing, and financial situation.Öğe The effect of growth hormone on motor findings and dendrite morphology in an experimental Parkinson's disease model(Springer, 2024) Kirazli, Ozlem; Ozkan, Mazhar; Verimli, Ural; Gulhan, Rezzan; Arman, Ahmet; Sehirli, Umit SuleymanApproaches for the induction of neurogenesis and neuronal recovery through several modalities are gaining popularity in Parkinson's disease (PD). Growth hormone (GH) seems to have a role in the reversal of neural function following brain injury as well as in normal brain development and function; therefore, the use of GH may represent a feasible strategy in the management of PD. This experimental study aimed to evaluate the effect of growth hormone on motor function and dendrite morphology in rats with 6-hydroxydopamine (6-OHDA)-induced PD model. Thirty-six Sprague Dawley rats were included and randomly allocated into one of the six study groups: two controls and four treatment groups that received daily subcutaneous growth hormone injections for 21 days, 1, 2, and 3 months. PD model was induced through unilateral 6-OHDA injection to the nigrostriatal pathway. The following assessments were made: apomorphine rotation test, stepping test, and tissue examinations for tyrosine hydroxylase and dendrite morphology. The apomorphine rotation test and the stepping test confirmed the presence of PD. These tests as well as dendritic spine density/number and length assessments showed improvement in PD findings over time with GH administration. Findings of this study suggest that GH administration may improve dendrite morphology and motor function in the PD model, which may translate into symptom relief and quality of life improvement in patients with PD. Such potential benefits should be tested in robust clinical studies.
