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Öğe Can the SYNTAX score predict mortality in patients with cardiac arrest?(Assoc Medica Brasileira, 2024) Demirkiran, Aykut; Aydin, Cihan; Orun, Serhat; Kaplangoray, MustafaOBJECTIVE: Sudden cardiac death or arrest describes an unexpected cardiac cause-related death or arrest that occurs rapidly out of the hospital or in the emergency room. This study aimed to reveal the relationship between coronary angiographic findings and cardiac death secondary to acute MATERIALS AND METHODS: Patients presenting with acute ST-elevation myocardial infarction complicated with cardiac arrest were included in the study. The severity of coronary artery disease, coronary chronic total occlusion, coronary collateral circulation, and blood flow in the infarct-related artery were recorded. Patients were divided into two groups, namely, deaths secondary to cardiac arrest and survivors of cardiac arrest. RESULTS: A total of 161 cardiac deaths and 42 survivors of cardiac arrest were included. The most frequent (46.3%) location of the culprit lesion was on the proximal left anterior descending artery. The left-dominant coronary circulation was 59.1%. There was a difference in the SYNTAX score (16.3 +/- 3.8 vs. 13.6 +/- 1.9; p=0.03) and the presence of chronic total occlusion (19.2 vs. 0%; p=0.02) between survivors and cardiac deaths. A high SYNTAX score (OR: 0.38, 95%CI: 0.27-0.53, p<0.01) was determined as an independent predictor of death secondary to cardiac arrest. CONCLUSION: The chronic total occlusion presence and SYNTAX score may predict death after cardiac arrest secondary to ST-elevation myocardial infarction.Öğe Comparison of topical capsaicin and topical piroxicam in the treatment of acute trauma-induced pain: A randomized double-blind trial(W B Saunders Co-Elsevier Inc, 2020) Koçak, Abdullah Osman; Dogruyol, Sinem; Akbaş, Ilker; Menekse, Tugba Sanalp; Gür, Sultan Tuna Akgöl; Koçak, Meryem Betos; Çakır, Zeynep; Orun, SerhatBackground: This study aimed to compare the analgesic efficacy of topical capsaicin and topical piroxicam in acute musculoskeletal injuries. Methods: This is a prospective, randomized, controlled, double-blinded study. The data for the 67 patients in the piroxicam group and the 69 in the capsaicin group were examined. The initial visual analog scale (VAS) scores were compared with the 60th and 120th minute as well as the 24th and 72nd hour values. Differences between the VAS scores, clinical effectiveness of the treatment and side effects were evaluated. Results: In the capsaicin group, the mean difference in the delta VAS scores was significantly higher at each measurement time. The mean of the percentage of reduction in the VAS scores of the topical capsaicin group was significantly higher than that in the topical piroxicam group. The highest difference in terms of both outcomes was determined at the 72nd hour VAS change. Mean differences were 1.53 (95% CI: 0.85-2.221) and 19.7 (95% CI: 12.4-27.2) respectively (p < 0.001). In the capsaicin group, the clinical effect of the treatment was found significantly higher (p < 0.01). The difference between the clinical effectiveness of the groups regarding the treatment outcomes was also statistically significant (p < 0.001). There was no significant difference between the patient groups regarding the presence of side effects. Conclusion: Topical capsaicin can be used as an alternative to topical piroxicam initially and at follow-up in patients presenting to the emergency department with acute pain as there were no observable differences in side-effects between the two groups. (c) 2020 Elsevier Inc. All rights reserved.Öğe Demographic Characteristics of Occupational Accidents Admitted to the Emergency Department of Tekirdağ Namık Kemal University Hospital(Galenos Publ House, 2025) Basol, Batuhan Ilbey; Orun, Serhat; Sahin, Huseyin; Bicakci, SercanAim: It was aimed to evaluate the demographic characteristics of patients who were admitted to our emergency department due to occupational accidents and to examine the outcomes of the forensic reports.Materials and Methods: The electronic files and forensic reports of patients admitted to our emergency department due to occupational accidents between 01.01.2020 and 31.12.2020 were retrospectively analyzed.Results: The mean age of the 235 cases included in our study was 33.9 +/- 10.9 years. The number of male cases was 192 (81.7%) and the number of female cases was 43 (18.3%). The shift with the highest number of occupational accidents was day shift with 125 cases (53.2%). The most common mechanisms of occupational accidents were injuries caused by work machines/tools with 111 (47.2%) cases. In 82 (34.9%) cases, simple soft tissue trauma was the most common diagnosis. Two hundred seventeen (92.3%) of the cases were discharged, while 1 (0.4%) died. In the forensic reports of 48 (20.4%) of the current cases, it was not stated whether their current condition could be resolved by simple medical intervention. A permanent report was written in 2 (0.8%) of all forensic reports.Conclusion: Occupational accidents presenting to our emergency department are most commonly seen in young adult males in their thirties and during day shifts. The mechanism of development of occupational accidents and the diagnoses received by patients differ among health centers. Physicians working in our emergency department tend to share medical and judicial responsibilities with other specialtiesÖğe Diagnostic accuracy of adropin as a preliminary test to exclude acute pulmonary embolism: a prospective study(Bmc, 2022) Orun, Serhat; Çelikkol, Aliye; Başol, Batuhan İlbey; Yeniay, ElifBackground This study aims to investigate the diagnostic accuracy of adropin as a biomarker to exclude the diagnosis of acute pulmonary embolism (PE). Methods Patients admitted to the emergency department of a tertiary health centre between August 2019 and August 2020 and diagnosed with PE were included in this prospective cohort study. The amount of serum adropin was determined in patients with (PE) and compared with that of healthy volunteers. Receiver operating characteristic analysis was performed with the obtained data, and the area under the curve (AUC) with a 95% confidence interval was determined. The parameters of diagnostic accuracy for PE were determined. Results A total of 57 participants were included in the study (28 controls and 29 PE patients). The mean adropin level in the PE group was 187.33 +/- 62.40 pg/ml, which was significantly lower than that in the control group (524.06 +/- 421.68 pg/ml) (p < 0.001). When the optimal adropin cut-off value was 213.78 pg/ml, the likelihood ratio of the adropin test was 3.4, and the sensitivity of the adropin test at this value was 82% with specificity of 75% (95% CI; AUC: 0.821). Conclusion Our results suggest that adropin may be considered for further study as a candidate marker for the exclusion of the diagnosis of PE. However, more research is required to verify and support the generalizability of our study results.Öğe Exploring the Association Between Serum Neurogranin, Nardilysin, and Ischemic Stroke: A Case-Control Study Conducted in the Emergency Department(Int Scientific Information, Inc, 2025) Ozensoy, Habibe Selmin; Orun, Serhat; Guru, Selahattin; Oguz, Esra FiratBackground: Ischemic stroke (IS) is a major cause of mortality and disability worldwide. Rapid and accurate diagnosis in the emergency department (ED) is crucial for improving outcomes. Neurogranin (Ng), a postsynaptic protein involved in synaptic plasticity, and Nardilysin (NRDC), a metallopeptidase with neuronal functions, have been linked to various neurological disorders. This study examines their potential diagnostic and prognostic value in IS. Material/Methods: This prospective case-control study was carried out in a high-volume ED between June and October 2023. A total of 44 IS patients and 44 healthy controls, matched for age and sex, were included. Serum levels of Ng and NRDC were measured using enzyme-linked immunosorbent assay (ELISA). Statistical analyses involved receiver operating characteristic (ROC) analysis to assess diagnostic value and comparisons of biochemical parameters between groups. Results: Ng levels were significantly higher in IS patients compared to controls (281.12 +/- 32.12 pg/mL vs 265.71 +/- 24.54 pg/mL, P=0.01), with moderate diagnostic accuracy (area under curve=0.624). Elevated Ng levels were associated with intensive care unit admission (311.50 +/- 46.13 pg/mL, P=0.023). NRDC levels showed no significant differences between groups or clinical outcomes. Biochemical parameters, including elevated urea and creatinine and reduced hemoglobin levels, showed the systemic impacts of IS. Conclusions: Ng may have a limited role as a biomarker in IS diagnosis, while its potential prognostic value requires further validation. NRDC did not show significant utility in this study. Larger studies incorporating additional biomarkers are needed to determine whether Ng can provide clinical insights into IS diagnosis and prognosis.Öğe The Importance and Its Relationship of Adropin Level in Prediting the Severity of Acute Pancreatitis(Galenos Publ House, 2023) Sahin, Huseyin; Nahmadova, Gunay; Bicakci, Sercan; Bicakci, Nurcan; Erdem, Mustafa Numan; Orun, Serhat; Basol, Batuhan IlbeyAim: We sought an alternative marker without serum amylase-lipase test for diagnosis in acute pancreatitis (AP), a disease with a wide range of severity. In this study, we wanted to see the benefit of serum adropin levels in improving the diagnosis time in the emergency department, predicting the severity of pancreatitis, and hospitalization. Materials and Methods: Our study is a single-center prospective study in which 39 patients with AP (>= 18 years old) participated. Thirty-six patients diagnosed with AP and 36 control group admitted to the Emergency Department of Tekirda & gbreve; Nam & imath;k Kemal University Hospital between March 2021 and November 2021 were included in the study. The blood samples of the patient and control groups at admission were studied by ELISA method. All patients diagnosed with AP were hospitalized and a package program called Statistical Package for the Social Sciences was used in the statistical analysis of the data obtained. Results: In our study results; There was no statistically significant difference in adropin levels compared to the patient/control group (p>0.05). When the ROC curves of the patient/control group were examined in terms of adropin levels; It was determined that the adropin level distinction was not statistically significant (p=0.336 >0.05). At the same time, no statistically significant difference was found in terms of adropin levels according to pancreatitis types and pancreatitis score classes of the patients (p>0.05). Conclusion: According to our study, adropin is not a significant biomarker in determining the diagnosis and severity of AP.
