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Adenomatöz kolon polipli hastalarda oksidatif stres mekanizmasının paraoksonaz ve arilesteraz üzerinden değerlendirilmesi
(2013) Aydın, Murat; Tülübaş, Feti; Bali, İlhan; Mete, Rafet; Oran, Mustafa; Yıldırım, Oğuzhan; Gürel, Ahmet
Amaç: Adenomatöz polip, rektum ve kolonda adenomların lümene doğru gelişimi ile karakterize klinik bir durumdur. Birçok dejeneratif ve tümöral hastalığın patogenezinde artmış oksidatif stres rol oynamaktadır. Bu çalışma adenomatöz kolon polipli hastalarda paraoksonaz, indüklenebilir paraoksonaz ve arilesteraz enzim aktivitelerinin tespiti ve oksidatif stres ile hastalığın patofizyolojisi arasındaki ilişkiyi ortaya koymak amacı ile planlanmıştır. Gereç ve yöntem: Namık Kemal Üniversitesi Araştırma ve Uygulama Hastanesi Gastroenteroloji Polikliniği'ne başvuran hastalardan kolon polipi saptananlar ve sağlıklı gönüllüler çalışmaya alındı. Paraoksonaz, indüklenebilir paraoksonaz ve arilesteraz düzeylerinin ölçümleri spektrofotometrik olarak yapıldı. Bulgular: Kolon polipli hastalar ile sağlıklı kontroller karşılaştırıldığında, kolon polipli hastalarda, paraoksonaz, indüklenebilir paraoksonaz aktiviteleri istatistiksel olarak anlamlı oranda düşük bulunurken, arilesteraz aktivitesinde istatistiksel olarak anlamlı fark bulunmadı. Sonuç: Kolon polipli hastalarda paraoksonaz ve indüklenebilir paraoksonaz aktivitesinin sağlıklı polülasyondan düşük bulunması, oksidan-antioksidan dengenin oksidan yönünde bozulmasının polipli hastalarda polip gelişimi ile yakın ilişki içinde olduğunu düşündürmektedir
Association between drug resistant hypertension and increased osteoprotegerin levels in hypertensive male patients with non obstructive sleep apnea
(Carbone Editore, 2014) Akyüz, Aydın; Oran, Mustafa; Alpsoy, Şeref; Mutlu, Levent Cem; Değirmenci, Hasan; Küçükyalçın, Volkan; Alp, Recep
Objectives: Increased carotid intima-media thickness (IMT) reflects subclinical vascular damage and is related to obstructive sleep apnea (OSA) syndrome and hypertension. Osteoprotegerin OPG is a member of the tumor necrosis factor superfamily and increases leukocyte adhesion. The relationship between increased OPG and atherosclerosis is Well known, but there is still no evidence whether there is an association between OPG and resistant hypertension. This study investigated the association between OPG and drug resistant hypertension in patients With OSA and non-OSA. Patients and methods: We investigated the association between serum OPG levels and carotid IMT in patients With drug resistant hypertensive OSA (ODR) patients (n= 39) and drug resistant hypertensive non-OSA(NODR) patients (n=34) and drug-responsive hypertensive non-OSA controls (n=36). Results: OPG levels and carotid IMT were found to be higher in the ODR [12.4(5.9-19.5) and 0.89 +/- 0.51 and in the NODR group [11.9(5.7-17.6) and 0.88 +/- 0.6] compared with the controls [8.4(4.8-16.5) pmollL and 0.73 +/- 0.8 um], (p= 0.01 and p=0.01 for OPG and p<0.01 and p<0.01 for carotid IMT). The carotid IMT was positively correlated with OPG levels in the ODR. group (r=0.412, p=0.016) and in the NODR group(r=0.321, p=0.024) and with apnea hypopnea index (r=0.462, p<0.001) in the ODR. There was no correlation between OPG and apnea-hypopnea index (r=0.07, p=0.564) in the ODR group. Conclusions: Increased serum OPG levels were associated with subclinical carotid atherosclerosis in patients with ODR and NODR, but not with drug-response non-OSA controls.
Association Between Serum Fetuin-A levels, Carotid Artery Stiffness, and Intima-Media Thickness in Patients With Normotensive Obstructive Sleep Apnea Syndrome
(Sage Publications Inc, 2014) Akyüz, Aydın; Oran, Mustafa; Alpsoy, Şeref; Mutlu, Levent Cem; Akkoyun, Dursun Çayan; Güzel, Savaş; Alp, Recep
Increased carotid intima-media thickness (cIMT) and stiffness, reflecting subclinical atherosclerosis, are associated with obstructive sleep apnea syndrome (OSAS). The relationship between serum fetuin-A, which inhibits ectopic calcification, and atherosclerosis is unclear. Therefore, we investigated the association between serum fetuin-A levels and carotid artery stiffness and cIMT in patients with normotensive OSAS (n = 50) and non-OSAS controls (n = 38). Compared with controls, there were lower fetuin-A levels (59.4 +/- 6.5 vs 68.2 +/- 5.8 ng/mL, P = .029), higher mean cIMT (0.73 +/- 0.2 vs 0.63 +/- 0.3 mm, P < .001), and greater stiffness (beta) index (7.45 +/- 0.9 vs 5.2 +/- 0.7, P = .001) in the OSAS group. The cIMT and stiffness (beta) index were inversely correlated with fetuin-A levels (r = -.324, P = .033; r = -.466, P < .001, respectively) and positively correlated with apnea hypopnea index (r = .498, P < .001; r = .422, P = .001, respectively) in the OSAS group. Decreased serum fetuin-A levels were associated with subclinical carotid atherosclerosis in patients with normotensive OSAS.
Association of colon adenomas and skin tags: coincidence or coexistence?
(Verduci Publisher, 2014) Oran, Mustafa; Erfan, Gamze; Mete, Rafet; Yanık, Mehmet Emin; Yıldırım, Oğuzhan; Aydın, M.; Topçu, Birol
OBJECTIVES: Skin tag (STs) are benign connective tissue tumors of the dermis. Some researchers have argued that there is a relationship between skin tag and colon polyps, although the physiopathological mechanisms underlying this relation were not well elucidated. In this study we aimed to investigate the co-existence of colonic adenomatous polyps and ST, additionally to shed light on the physiopathological mechanisms underlying this coincidence. PATIENTS AND METHODS: A total of 45 patients aged between 18 and 60 diagnosed with adenomatous colonic polyps and 45 sex, age, and socio-demographically matched subjects, had no polyps, were enrolled as the control group. Routine blood analysis of all participants, including serum glucose, total cholesterol, low-density lipoprotein cholesterol (LDL-C), (high-density lipoprotein cholesterol (HDL-C), triglyceride, insulin, IGF-1, and EGF, were performed. The chi-square and independent sample t or Mann Whitney U test were used to determine differences between groups. RESULTS: The number of participants with ST was significantly higher in the patient group (OR 7.067, p < 0.01). Serum levels of IGF-1 and EGF were statistically similar between the groups. In the subgroup analyses, no difference was found in serum levels of insulin, IGF-1, or EGF between patients with and without ST. However, higher serum levels of insulin and EGF were found in control subjects with ST (p < 0.01 and p < 0.01, respectively). For the entire study group, 67 participants had ST and 23 patients did not. Serum insulin, and IGF-1 were similar, while serum EGF levels were higher in patients with ST (p < 0.01). CONCLUSIONS: Findings of the present study may show a co-existence of colonic polyps and ST. Although previous studies have indicated that insulin resistance may play a role in the pathogenesis of both lesions in diabetic and obese patients, we found no indication of a relationship in nondiabetic and nonobese patients with increased levels of EGF in patients with ST, suggesting an alternative pathogenesis in this patient group.
Asymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with COPD
(Wiley, 2017) Aydın, Murat; Altıntaş, Nejat; Mutlu, Levent Cem; Bilir, Bülent; Oran, Mustafa; Tülübaş, Feti; Gürel, Ahmet
IntroductionAsymmetric dimethylarginine (ADMA) and nitric oxide (NO) show their mechanism of action reciprocally, the balance between these molecules contributes to the tight regulation of airways tone and function. ObjectivesThe aim of this study to determine the serum levels of ADMA and NO in patients with chronic obstructive pulmonary disease (COPD) and establish whether their level vary in relation to forced expiratory volume in 1s (FEV1), to assess their role in pathophysiology of COPD. Materials and MethodsThis study consisted of 58 patients with COPD and 30 healthy subjects. Serum ADMA and NO levels were measured using enzyme-linked immunosorbent assay and the colorimetric method, respectively. ResultsSerum ADMA levels were significantly higher, however, NO levels were lower in patients with COPD compared with controls. ADMA levels were inversely correlated with NO levels. Serum ADMA and NO were significantly correlated with FEV1. Multivariable logistic regression analysis revealed that serum ADMA and NO were independently and significantly associated with the presence of COPD. Multiple linear regression analysis showed that COPD was positively associated with ADMA, additionally COPD and ADMA were independently and inversely associated with NO. NO levels were decreased, ADMA levels were increased compliant with progression of COPD stages. ConclusionWhile circulating ADMA is higher, NO is lower in COPD and both show a strong correlation to the degree of airflow limitation. ADMA seems to be a possible new marker of prognosis of COPD and can be a novel therapeutic target for the treatment of COPD.
Asymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with COPD (Meeting Abstract)
(European Respiratory Soc Journals Ltd, 2015) Aydın, Murat; Altıntaş, Nejat; Mutlu, Levent Cem; Bilir, Bülent; Oran, Mustafa; Tukubas, Feti; Topçu, Birol
[No Abstract Available]
Caga Strain of Helicobacter Pylori in Recurrent Aphtous Somatitis Patients Without Dyspeptic Symptoms: Response to Eradication Therapy
(Carbone Editore, 2014) Erfan, Gamze; Mete, Rafet; Oran, Mustafa; Yanık, Mehmet Emin; Güneş, Hayati; Kaya, Şule; Topçu, Birol
Helicobacter pylori (HP) play a role as an etiological factor of soine dermatological diseases such as rosacea and Behcet disease. Recurrent aphtus stomatitis (RAS) is the most common mucosal disease with unknown etiology. Several microbial agents such as HP also have been proposed as causative factors for this disease. Although some of the studies do not support a strong association between HP and RAS, the relationship might differ when the virulence of the infecting strains are examined. The cytotoxin-associated gene A (CagA) is one of the virulence factors of HP and has impact in some of the extra gastrointestinal dermatological diseases such as rosacea. In this study; the seroprevelance of CagA of non-dyspeptic RAS patients and the eradication treatment response in CagA positive and negative RAS patients were examined. In 87 RAS patients and 72 healthy volunteers; 43.6% of RAS patients and 25% of control subjects were CagA (+). The number of CagA (+) patients were significantly higher in RAS group. (OR: 3.61, 95%CI: 1.21-10.7, p=0.01). Out of 45 HP (+); 32 (80%) of patients who underwent eradication treatment assessed three months after treatment. In CagA (+) RAS patients; composite index score of RAS after eradication was significantly lower than before treatment (p 0.01) but in CagA (-) RAS patients statistical analysis revealed no difference (p= 0.11). The CagA strain of HP is significantly higher even in non-dyspeptic RAS patients than healthy cases. The eradication treatment in these patients with HP and CagA seropositivity improves symptoms of RAS.
Carotid intima-media thickness and serum paraoxonase-1 activity in patients with Helicobacter pylori
(Verduci Publisher, 2013) Mete, Rafet; Oran, Mustafa; Alpsoy, Şeref; Güneş, H.; Tülübaş, Feti; Turan, C.; Yıldırım, Oğuzhan
AIM: To evaluate serum paraoxonase(PON)-1 activity and carotid intima-media thickness (CIMT) in patients with Cytotoxin-associated antigen(CagA)-positive and negative Helicobacter pylori strains. PATIENTS AND METHODS: The study group included a total of 134 individuals, of whom 103 were H. pylori positive, and 31 were H. pylori negative. Five biopsies were collected from each patient for histological examination: two from the antrum, two from the corpus, and one from the incisura angularis. The presence of H. pylori was determined using a modified Gram staining protocol. Peripheral blood was collected from each patient to determine levels of triglyceride, TC, HDL-cholesterol and LDL-cholesterol. IgG antibodies against CagA protein were analyzed by enzyme immunoassays. PON-1 activity was measured by colorimetric method. Carotid intima-media thickness and atherogenic plaques were measured using a grey scale color Doppler ultrasound. Data were analyzed by descriptive and inferential statistics. RESULTS: The right, the left and the mean CIMT were significantly higher in H. pylori (+) group versus H. pylori (-) group (p < 0.001 for all). However, the mean PON-1 concentration was significantly lower in H. pylori (+) group versus H. pylori (-) group (p < 0.001). The right, the left and the mean CIMT of CagA (+) group were significantly higher than that of CagA (-) group and controls, while PON-1 concentrations of CagA (+) group were significantly lower than that of CagA (-) group and controls (for all p = 0.0001). The right, the left and the mean CIMT of CagA (-) group were significantly higher than that of the control group, while the mean PON-1 concentration were significantly lower (for all p = 0.0001). CONCLUSIONS: Decreased PON-1 activity may be an etiopathogenetic factor in increased atherosclerosis in patients with H. pylori infection, especially in those infected with the CagA positive strain.
Cytotoxin associated gene A+ helicobacter pylori ınfection is related with endothelial dysfunction in normotensive ındividuals
(2014) Akyüz, Aydın; Mete, Rafet; Oran, Mustafa; Alpsoy, Şeref; Akkoyun, Dursun Çayan; Değirmenci Osanmaz, Pelin; Avcı, Okan
Giriş: Sitotoksin ilişkili A genli Helicobacter pylori (SİAGHP), en çok virülansı olan H. pylori tipidir ve halen endotelyal disfonksiyon ile ilişkisi belirsizdir. Bu nedenle biz SİAGHP’nin endotelyal bağımlı dilatasyon üzerine etkilerini ve C-reaktif protein (CRP) düzeyleri ile ilişkisini normotansif bireylerde araştırdık. Hastalar ve Yöntem: SİAGHP enfeksiyonu olan 60 kişi, sitotoksin ilişkili A geni negatif H. pylori (SAİGNHP) enfeksiyonlu 40 kişi ve enfeksiyonu olmayan 50 kişi ile akım aracılı dilatasyon (AAD), endotele bağımlı olmayan dilatasyon (EBOD) ve CRP düzeyleri yönünden karşılaştırıldı. Bulgular: SİAGHP’li bireylerde ortalama AAD’nin yüzdesi (6,3±2,7) SİAGNHP olanlardan (9,8±3,3, p<0,01) ve enfekte olmayan kontrol grubundan (10,1±2,6, p<0,01) belirgin olarak düşüktü. CRP’nin ortalama düzeyleri SİAGHP’li bireylerde 3,9 mg/dL (0,1-9,8 aralığında), SİAGNHP olanlardan (2,3 mg/dL, 0,1-5,4 aralığında, p=0,01) ve enfekte olmayan kontrol grubundan (1,9 mg/dL, 0,1-5,3 aralığında, p<0,01) daha yüksek idi. SİAGHP’li bireylerde CRP düzeyleri AAD ile ters korelasyon gösterdi (r=0,318, p=0,013), fakat EBOD ile bu korelasyon görülmedi. Sonuç: Azalmış AAD ve düşük düzeyde inflamasyon SİAGHP enfeksiyonu ile ilişkilidir, ancak SİAGNHP ile ilişkili değildir.
Detection of subclinical atherosclerosis and diastolic dysfunction in patients with schizophrenia
(Dove Medical Press Ltd, 2013) Ünsal, Cüneyt; Oran, Mustafa; Oktay Türeli, Hande; Alpsoy, Şeref; Yeşilyurt, Sema; Arslan, Mehtap; Kurt, Erhan
Background: Patients with schizophrenia have a higher risk for cardiovascular diseases, which is associated with early mortality compared with the nonschizophrenic population. Early diagnosis of cardiovascular diseases in asymptomatic periods in patients with schizophrenia would enhance their quality of life and reduce mortality. Echocardiography, carotid ultrasonography, and ankle brachial index (ABI) measurement are known to be beneficial methods of detecting subclinical cardiovascular diseases and of risk stratification. The present study investigated carotid intima media thickness (CIMT) and ABI and echocardiographic parameters measured via conventional and tissue Doppler echocardiography in patients with schizophrenia in comparison with a control group. Methods: The present case-control study included 116 patients with schizophrenia and 88 healthy patients. Participants with any current comorbid psychiatric disorder, current or lifetime neurological and medical problems, current coronary artery disease, diabetes, hypertension, hypothyroidism, or hyperthyroidism or who were using antihypertensives, antidiabetic agents, or antiobesity drugs were excluded. High-resolution B-mode ultrasound images were used to measure CIMT. Conventional and tissue Doppler measurements were performed according to the recommendations of the American Society of Echocardiography. Results: Low ABI, mitral ratio of the early (E) to late (A) ventricular filling velocities, septal E', septal S', lateral E', lateral S', septal E'/septal A', lateral E'/lateral A', and high septal A', mitral E/septal E', mitral E/lateral E', and CIMT values were observed in the schizophrenia group compared with the control group. Conclusion: Doppler parameters supported the hypothesis that patients with schizophrenia are at high risk for cardiovascular diseases.
Effect of lifestyle modifications on diastolic functions and aortic stiffness in prehypertensive subjects: a prospective cohort study
(Aves, 2013) Alpsoy, Şeref; Oran, Mustafa; Topçu, Birol; Akyüz, Aydın; Akkoyun, Dursun Çayan; Değirmenci, Hasan
Objective: Prehypertension is one of the primary causes of major cardiovascular events independent from other cardiovascular risk factors. The aim of the study was to evaluate the effect of therapeutic lifestyle modifications (LSMs) on cardiac diastolic function and aortic stiffness in prehypertensive subjects. Methods: This study designed as a prospective cohort study. Sixty-one prehypertensive adults were included in this study. The goals of LMS were weight loss of at least 5 kg in subjects with a BMI >= 25 kg/m(2) and moderate-intensity physical activity at least 180 minutes per week. We evaluated left ventricular (LV) diastolic function and aortic stiffness parameters at baseline and after 6 months by conventional and tissue Doppler imaging (TDI) echocardiography. Statistical analyses were performed using Wilcoxon-signed rank test and the paired sample t test. Results: Transmitral early velocity (E), the ratio of E to transmitral late velocity (E/A), TDI diastolic early septal velocity (septal E), TDI systolic septal velocity (septal S), TDI early lateral velocity (lateral E), the ratio of septal E to TDI late septal (septal A) velocity (septal E/A) and the ratio of lateral E to late lateral (lateral A) velocity (lateral E/A) were found to be significantly increased after the LSMs (p<0.05 for all). The beta stiffness index was decreased (12.07 vs. 6.33; p < 0.001) and the aortic compliance (0.02 cm/mmHg vs. 0.05 cm/mmHg; p<0.001) and the aortic strain (3.28% vs. 7.02%; p<0.001) were increased significantly after the LSMs. Conclusion: LSMs improve conventional and TDI echocardiographic parameters and aortic stiffness measurements in subjects with prehypertension.
Effects of hemodialysis on the left and right heart functions in patients with end-stage renal disease
(2013) Alpsoy, Şeref; Akyüz, Aydın; Oran, Mustafa; Yaman, Reşit; Akkoyun, Dursun Çayan; Topçu, Birol; Değirmenci, Hasan
Amaç: Kronik böbrek yetmezli ği olan hastalarda morbidite ve mortalite riskinin arttığı bilinmektedir. Kronik böbrek yetmezliği olan hastalarda hemodiyalizin sol ve sağ ventrikül sistolik ve diyastolik fonksiyonları üzerine etkisini konvansiyonel ve doku Doppler ekokardiyografi ile değerlendirmeyi amaçladık. Materyal ve metod: Bu ileriye dönük gözlemsel çalışmada hemodiyaliz öncesi ve diyalizden 60 dakika sonra 41 üremik hasta ekokardiyografi ile değerlendirildi. İki boyutlu, M- Mode, konvansiyonel ve doku Doppler ekokardiyografi ile sol ve sağ ventrikülün sistolik ve diyastolik fonksiyonları ölçüldü. Bulgular: Hemodiyaliz sonrası kalp hızı anlamlı olarak artarken ortalama vücut ağırlığı, sistolik ve diyastolik kan basınçları azaldı (hepsi için p<0.001). Hemodiyaliz öncesine kıyasla hemodiyaliz sonrasında mitral E/ mitral anulus septal E' ve mitral E/ mitral anulus lateral E' değerleri değişmedi (p= 0.105 ve p= 0.165), fakat M-mode, geleneksel ve diğer doku Doppler parametrelerinde anlamlı değişiklikler oldu (tüm p değerleri < 0.05 ve < 0.01). Sonuçlar: Mitral E/ septal E' ve mitral E/ lateral E' değerleri dializ sonrası değişmez, bu nedenle hemodiyaliz hastalarında diyastolik fonksiyonları değerlendirmek için en iyi parametrelerdir. Konvansiyonel ve diğer doku Doppler parametreleri hemodiyaliz ile değiştiği için bu hastalarda doğru sonuçlar vermez.
Evaluation of Paraoxonase and Arylesterase activities in patients with irritable bowel syndrome
(Pakistan Medical Assoc, 2014) Oran, Mustafa; Tülübaş, Feti; Mete, Rafet; Aydın, Murat; Sarıkaya, Hatice Gul; Gürel, Ahmet
The aims of the present study were to evaluate oxidative status, by investigating the serum Paraoxonase/Arylesterase (PON/ARE) activities along with conjugated dienes in patients with IBS and controls and to confirm the link between oxidative stress and IBS. Thirty IBS patient and 30 healthy subjects were recruited. Total serum cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), PON and ARE activities and conjugated dienes levels were measured. Mean serum PON1 activity was lower in IBS group compared to that of the control group whereas there was no significant difference in ARE activity between IBS and control groups (p<0.000, p<0.716, respectively). Serum conjugated diene levels of the IBS group was significantly higher than that of the control group (p<0.01). The drop in PON activity accompanied with an increase in conjugated diene levels indicate the presence of oxidative stress, a disturbance in prooxidant - antioxidant balance and increased inflammation in IBS patients.
Growth Differentiation Factor-15 Is a Novel Biomarker Predicting Acute Exacerbation of Chronic Obstructive Pulmonary Disease
(Springer/Plenum Publishers, 2015) Mutlu, Levent Cem; Altıntaş, Nejat; Aydın, Murat; Tülübaş, Feti; Oran, Mustafa; Küçükyalçın, Volkan; Kaplan, Gizem; Gürel, Ahmet
Exacerbations in chronic obstructive pulmonary disease (COPD) reduce quality of life and are associated with a more rapid deterioration of the disease. Growth differentiation factor-15 (GDF-15) is a novel candidate exacerbation biomarker. In this study, we aimed to assess GDF-15 as a biomarker of acute exacerbation of COPD (AE-COPD). Lung function parameters, arterial blood gas analysis, and circulating levels of GDF-15, C-reactive protein (CRP), and fibrinogen were assessed in 29 patients on admission to the hospital for AE-COPD, in 29 age-, gender-, and body mass index (BMI)-matched patients with stable COPD, and 29 matched controls with normal lung function. Patients with AE-COPD had higher circulating concentrations of GDF-15 (p < 0.001), CRP (p < 0.001), and fibrinogen (p < 0.002) compared with patients with stable COPD and healthy controls. GDF-15 levels correlated with systemic inflammatory marker CRP in patients with AE-COPD (r = 0.677, p < 0.001) and with stable COPD (r = 0.417, p = 0.024). Multivariate logistic regression analysis revealed GDF-15 (odds ratio 18.16, 95 % confidence interval (CI) 2.51-134.32; p = 0.005) as an independent predictor of AE-COPD. In receiver operating characteristic analysis, GDF-15 achieved an area under the curve of 0.78 for the identification of AE-COPD. In conclusion, GDF-15 is a novel blood biomarker of AE-COPD that is more sensitive than that of CRP. GDF-15 may offer new insights into the pathogenesis of AE-COPD.
Helicobacter Pylori Pozitif Alopesi Areata ve Vitiligo Hastalarında Cag-A İlişkisi
(2015) Erfan, Gamze; Oran, Mustafa; Mete, Rafet; Güneş, Hayati; Yanık, Mehmet Emin; Albayrak, Hülya; Taşolar, Mustafa Kaan; Murat Aydın, Ayşe; Topçu, Birol; Kulaç, Mustafa
Amaç: Helicobacter Pylori (HP) ile bazı dermatolojik hastalıklar arasında ilişki kurulurken, alopesi areata (AA) ve HP arasında çelişkili veriler mevcuttur. Bu çelişkili sonuçların nedeni, HP'nin virulansından sorumlu faktörlerden biri olan Cag-A (sitotoksin ilişkili gen ürünü A) olabilir. Vitiligoda ise HP'nin muhtemel rolü hakkında tıbbı literatürde çok az sayıda çalışma bulunmaktadır. Literatürde tespit edilebildiği kadarıyla Cag-A (+) suşlarının rolünün saptandığı sadece bir çalışma bulunmaktadır. Yöntem: Altmış AA ve 52 vitiligo tanısı almış, dispepsi, eşlik eden otoimmün hastalıklar ve diğer enfeksiyonlar açısından hikâye, belirti, tanı ve tedavileri olmayan hastalar ve 60 sağlıklı bireyde HP stool antijeni ve serumlarında Cag-A seroprevelansı ELİSA kullanılarak incelendi. Hastalık şiddetleri AA grubunda alopesi şiddet ölçeği (SALT) skoru ve vitiligo grubunda ise "dokuzlar kuralı" ile ölçüldü ve HP, Cag-A pozitifliği ile ilişkisi karşılaştırıldı. Bulgular: AA grubunda 43 (%71,7), vitiligo grubunda 26 (%50) hastada HP (+)'liği saptandı. Bu hastalardan AA hastalarında Cag-A (+)'liği 26 (%60,4), vitiligo hastalarında 17 (%65,3) kişide saptandı. AA hastaları ile kontrol grubu karşılaştırıldığında, HP (+)'liği ve Cag-A (+)'liği AA hastalarında belirgin olarak yüksek sayıda saptanırken (p<0.05), vitiligo hastaları ile kontrol grubu karşılaştırıldığında ise HP (+)'liği ve Cag-A (+)'liği ile herhangi bir fark ve hastalık şiddeti açısından ilişki saptanmadı. Sonuç: Cag-A (+) HP suşları sağlıklı bireylere göre dispeptik olmayan AA hastalarında yüksek orandadır ancak vitiligo hastalarında bu yükseklik ve hastalık şiddetleri ile ilişki tespit edilememiştir.
Helikobakter pilori pozitif bireylerde endotel disfonksiyonu ile serum CRP ve B12 vitamin düzeyleri arasındaki ilişki
(2013) Alpsoy, Şeref; Oran, Mustafa; Mete, Rafet; Akyüz, Aydın; Akkoyun, Dursun Çayan; Topçu, Birol; Değirmenci, Hasan
Amaç: Çalışmanın amacı Helicobacter pylori (HP) seropozitif ve negatif bireylerde, endotel fonksiyon parametrelerini, C- reaktif protein (CRP) ve vitamin B12 düzeylerini ölçmek ve endotel fonksiyon parametreleri ile CRP ve vitamin B12 arasında ilişki olup olmadığını ortaya koymaktı. Materyal ve metod: Dispeptik yakınmaları olan110 kişide HP immünglobulin G antikor düzeyleri, CRP ve B12 vitamini düzeyleri ölçüldü. Brakiyal arter endotel-bağımlı (akım aracılı vazodilatasyon) ve endotel bağımsız (nitrogliserin bağlı) vazodilatasyon yanıtı ölçümleri yüksek frekanslı ultrasonografik görüntüleme ile yapıldı. Bulgular: HP immünglobulin G antikoru 70 kişide pozitif, 40 kişide ise negatifti. HP negatif bireylere kıyasla HP pozitif bireylerde brakiyal arter akım aracılı dilatasyon yanıtı azalmış, CRP düzeyi yüksek, vitamin B12 düzeyi ise düşüktü. HP pozitif bireylerde akım aracılı vazodilatasyon yanıtı ile yaş ve CRP arasında ters yönlü ilişki varken vitamin B12 ile aynı yönde ilişki vardı. Endotel bağımsız vazodilatasyon her iki grupta da benzerdi. Sonuç: Kronik HP enfeksiyonunda, sistemik ve vasküler inflamasyon artışı ve vitamin B12 eksikliği endotel disfonksiyonu gelişmesinde etkili olabilir
Hypofibrinolysis Is Associated with the Severity of COVID-19 Infection: the Role of Obesity
(Carbone Editore, 2021) Oran, Mustafa; Akpınar, Seval; Doğan, Mustafa; Avcı, Burcu Altındağ; Çelikkol, Aliye; Turgut, Burhan
Introduction: Obesity, by causing hypofibrinolysis and thrombotic complications, ought to be a risk factor in terms of disease severity and mortality in COVID-19 infection. We aim to investigate the effects of obesity on fibrinolytic system in coronavirus patients while studying the changes of major fibrinolytic inhibitors plasminogen activator inhibitor (PAI-1) and thrombin activatable fibrinolysis inhibitor (TAFI). Material and methods: Sixty-six patients and 21 healthy donors were investigated and observed until either their recovery or death. Body mass index (BMI) was calculated for each person and peripheral blood used for PAI-1 and TAFI measurements. PAI-1 antigen and TAFI activated/inactivated (TAFIa/i) were measured using ELISA kits. Results: PAI-1 antigen and TAFIa/i plasma levels are higher in patients than in control group (P<00001 for both). Patients needing ICU had higher TAFIa/i values than non-ICU patients. The 15 patients who died had higher TAFIa/i levels than those staying alive. Obese patients (BMI >= 30) had higher PAI-1 levels than non-obese patients. TAFIa/i is associated with D-dimer, C-reactive protein (CRP), ferritin, creatinine and neutrophile count, whereas PAI-1 is associated only with the serum creatinine level. Conclusion: Our study shows that the levels of the major fibrinolytic inhibitors PAI 1 and TAFI increase in patients with COVID-19 infection, and proves for the first time that PAI 1 levels increase more in obese patients than in non-obese ones. It is also revealed that the plasma TAFI level is associated with the severity of COVID-19 infection, which suggests that the inhibitory treatments against TAFI should be effective in preventing thrombotic complications in the course of COVID-19 infection.
Investigation of serum lipid levels in patients with iron deficiency anemia
(2013) Tülübaş, Feti; Oran, Mustafa; Mete, Rafet; Yılmaz, Ahsen; Yıldız, Zeynep Deniz; Gürel, Ahmet
Objective: Several metabolic pathways are affected by the reduction in the amount of iron in iron deficiency anemia (IDA). As a result, some hormonal control mechanisms, especially carbohydrates, proteins, nucleic acid metabolism, are influenced. In this study, we aimed to investigate the effect of IDA on serum lipid profile. Method: Files of 30 patients with IDA and 30 healthy people (both groups aged 18-60), who consulted to internal medicine and gastroenterology clinic in Nami{dotless}k Kemal University Faculty of Medicine, were scanned. The lipid and blood parameters of these people as well as their demographics were recorded. Results: While serum total cholesterol and low-density lipoprotein (LDL) levels were markedly lower in IDA cases than in controls, serum triglyceride, high-density lipoprotein (HDL) and very low-density lipoprotein (VLDL) levels did not differ in patients with IDA compared with the control group. Conclusion: It was observed that serum total cholesterol and LDL levels, whose main content is cholesterol, were decreased in IDA. We consider that reduction of iron levels changes cholesterol metabolism.
Investigation of serum macrophage migration inhibitor factor and monocyte chemotactic protein-1 levels in irritable bowel syndrome
(Tubitak Scientific & Technical Research Council Turkey, 2014) Tülübaş, Feti; Oran, Mustafa; Mete, Rafet; Turan, Filiz; Yılmaz, Ahsen; Yıldız, Zeynep Deniz; Gürel, Ahmet
Aim: Irritable bowel syndrome (IBS), a functional disorder of the bowel, has been thought to result from immune activation. The aim of this study was to evaluate macrophage migration inhibitory factor (MMIF) and monocyte chemotactic protein-1 (MCP-1) levels in IBS patients. Materials and methods: We enrolled 30 IBS patients and 30 healthy controls. The MMIF and MCP-1 levels of all patients and controls were detected using commercial enzyme-linked immunosorbent assay kits. Results: Serum MMIF and MCP-1 levels were markedly higher in IBS patients than in controls. White blood cell, neutrophil, lymphocyte, monocyte, eosinophil, and basophil counts did not differ significantly between groups. Conclusion: These results show that alterations in MMIF and MCP-1 affect the proinflammatory process. They also suggest that MMIF and MCP-1 may play a substantial role in IBS.
Iron Deficiency Anaemia is Associated with Decreased Levels of Macrophage Migration Inhibitory Factor and Monocyte Chemoattractant Protein-1
(Modestum Ltd, 2015) Oran, Mustafa; Tülübaş, Feti; Mete, Rafet; Aydın, Murat; Yıldız, Zeynep Deniz; Yılmaz, Ahsen; Gürel, Ahmet
Many bodily systems are affected by iron deficiency anaemia (IDA), including the immune system. However, the pathophysiological mechanisms whereby this anaemia promotes deterioration in immunity remain largely unexplained. In order to enlighten this pathophysiological link, serum levels of macrophage migration inhibitory factor (MIF) and monocyte chemoattractant protein-1 (MCP-1), which play an important roles in a healthy functioning immune system, were examined in patients with IDA and healthy volunteers. A total of 30 patients with IDA (mean age 33.6+/-7.8 years, 30% male) and 30 healthy individuals (mean age 30.1 +/- 8.8 years, 27 % male) were included. Serum MIF and MCP-1 levels were measured in a sandwich-assay format, using commercial enzyme-linked immunosorbent assay kits. There was no statistically significant difference in age and gender distribution between participants with IDA and controls (p> 0.05). Serum MIF and MCP-1 concentrations were lower in the IDA group than in the control group (p < 0.005, and p < 0.01, respectively). When considering the role of MIF and MCP-1 in maintaining the normal immune response of the organism, a decrease in production in patients with IDA may contribute to immune dysfunction in these individuals.

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