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Öğe Mefepronic acid, a PPAR agonist, is inefficient on reproductive performance of ewes in both early and late postpartum period(Sivar-Soc Italiana Veterinari Animali Reddito, 2023) Kutlu, Metehan; Dogan, Halef; Aktug, ErayThe liver is a dynamic organ that plays critical roles in many physiological processes. In farm animals, supporting the liver reduces postpartum metabolic diseases and loss of reproductive and milk yield in the transition period. The aim of this study is to investigate the effects of mefepronic acid (2-methyl-2-phenoxy propionic acid) injection on reproductive performance parameters with short-term progesterone administration in early and late postpartum period Hungarian Merino ewes during the non-breeding season. In the study, 89 adult ewes in the early (n=45) and late (n=44) postpartum (pp) period were used in the study. Control and treatment (MA) groups were formed separately for each pp period. Following insertion of a vaginal sponge containing 60 mg medroxyprogesterone acetate for 7 days, PMSG 500 IU was injected intramuscularly (day 7) to all ewes. In treatment groups (Early MA and Late MA), 10 mg/kg mefepronic acid (Hepagen((R)), Fatro Gunesli) was injected (day 7), and remaining ewes consisted of control groups (Early Control and Late Control). The estrus signs of the ewes were followed and they were handmated (ewe: ram=5:1). Pregnancies were determined with transabdominal real time B-Mode ultrasonography with convex probe (3.5 MHz) on day 45 post-mating. There were no statistical differences in estrus rate, pregnancy rate, lambing rate and litter size at 1st service, 2nd service and overall services in early and late pp groups. According to results of this study, administration of mefepronic acid to ewes in the early and late pp period had no increasing effect on reproductive parameters. However, further studies investigating the survival of embryos and prostaglandin metabolism are needed to determine the efficacy of mefepronic acid in ewes.Öğe Mefepronic acid, a PPAR agonist, is inefficient on reproductive performance of ewes in both early and late postpartum period(Massimo Morgante, 2023) Kutlu, Metehan; Dogan, Halef; Aktug, ErayThe liver is a dynamic organ that plays critical roles in many physiological processes. In farm animals, supporting the liver reduces postpartum metabolic diseases and loss of reproductive and milk yield in the transition period. The aim of this study is to investigate the effects of mefepronic acid (2-methyl-2-phenoxy propionic acid) injection on reproductive performance parameters with short-term progesterone administration in early and late postpartum period Hungarian Merino ewes during the non-breeding season. In the study, 89 adult ewes in the early (n=45) and late (n=44) postpartum (pp) period were used in the study. Control and treatment (MA) groups were formed separately for each pp period. Following insertion of a vaginal sponge containing 60 mg medroxyprogesterone acetate for 7 days, PMSG 500 IU was injected intramuscularly (day 7) to all ewes. In treatment groups (Early MA and Late MA), 10 mg/kg mefepronic acid (Hepagen®, Fatro Günesli) was injected (day 7), and remaining ewes consisted of control groups (Early Control and Late Control). The estrus signs of the ewes were followed and they were hand-mated (ewe: ram=5:1). Pregnancies were determined with transabdominal real time B-Mode ultrasonography with convex probe (3.5 MHz) on day 45 post-mating. There were no statistical differences in estrus rate, pregnancy rate, lambing rate and litter size at 1st service, 2nd service and overall services in early and late pp groups. According to results of this study, administration of mefepronic acid to ewes in the early and late pp period had no increasing effect on reproductive parameters. However, further studies investigating the survival of embryos and prostaglandin metabolism are needed to determine the efficacy of mefepronic acid in ewes. © 2023, Massimo Morgante. All rights reserved.Öğe Post-mating diclofenac vs. carprofen treatment on serum progesterone levels and reproductive outcomes in Hungarian-Merino ewes during the non-breeding season(Wiley, 2022) Kutlu, Metehan; Doğan, Halef; Alkan, Hasan; Serbester, Uğur; Kutlu, Hasan RüştüThe maternal recognition process is crucial for the establishment of healthy pregnancy. In this process, anti-luteolytic applications are one of the main reproductive strategies to manage the embryonic losses and maximize reproductive profitability in farm animals. The aim of this study was to investigate the efficacy of post-mating NSAID treatments on reproductive parameters (pregnancy rate, lambing rate, multiple birth rate, litter size) and serum progesterone levels in ewes stimulated with progesterone non-breeding season. For this purpose, two different experiments (diclofenac and carprofen) were conducted in the same ewe flock induced with short-term progestogen-based protocol in the non-breeding season for two consecutive years. In experiment 1 (n = 85), 42 ewes were injected with 2.5 mg/kg diclofenac on the 9th and 10th days post-mating, and the rest were not treated and served as control. In experiment 2 (n = 82), 40 ewes were injected with 1.4 mg/kg carprofen on the 9th days post-mating, and the rest were not treated as control. In both experiments, blood samples were collected from all ewes on days 9, 12 and 13 post-mating to measure serum progesterone levels. In both experiments, there were no differences both reproductive parameters and serum progesterone levels when compared to the control groups. It was concluded that post-mating diclofenac and carprofen treatments in the critical period have no significant effects on both reproductive parameters and serum progesterone levels in ewes in the non-breeding season.Öğe Üreme Sezonu Dışında Kısa Süreli Progestagen ve PMSG ile Senkronize Edilen Koyunlarda Ümmunmodülatör Kullanımının Vaginal Akıntı Skoru ve Konsepsiyon Oranı Üzerine Etkisi(2022) Doğan, Halef; Kutlu, MetehanÜreme sezonu dı?ında, koyunlarda en yaygın kullanılan östrüs uyarım protokollerinden birisi, kısa süreli progestagen ve gebe kısrak serum gonadotropin (PMSG) kombinasyonudur. Progestagenlerin genital organlarda olu?turduğu immunsupresyon ile birlikte intravaginal süngerlerin olu?turduğu irkiltici etki, çoğu kez vaginada deği?en derecelerde vaginal akıntı ve inflamasyona sebep olabilmektedir. Bu çalı?mada, kısa süreli intravaginal progestagen ve PMSG kombinasyonu ile östrüsleri uyarılan üreme sezonu dı?ındaki koyunlarda, protokole immunmodülatör ilavesinin vaginal akıntı skoru ve konsepsiyon oranı üzerindeki etkisinin ara?tırılması amaçlanmı?tır. Çalı?mada, 60 adet Macar merinosu ırkı koyun kullanıldı. Koyunlar rastgele iki e?it gruba ayrıldıktan sonra, deney grubuna (CCL), 10 mg Corynebacterium cutis lizatı uygulanarak, 7 gün süre ile progestagen içeren vaginal sünger uygulandı. Yedinci günde süngerler alınarak, 500 IU PMSG enjeksiyonu yapıldı. Kontrol grubuna (Kontrol) ise, sadece 7 gün intravaginal progestagen ve PMSG uygulaması yapıldı. Süngerlerin çıkarıldığı anda vaginal akıntı skorları belirlenerek kaydedildi. Koyunların östrüsleri takip edilerek elde a?ım yaptırıldı. Elde a?ımlar sonrası gebelik muayenesi yapılarak, gruplarda konsepsiyon oranları belirlendi. CCL ve Kontrol gruplarında östrüs oranları (%96.6 & %93.1; P>0.05) ve ortalama vaginal akıntı skorlarında (1.20 & 1.53; P>0.05) farklılık tespit edilmezken, konsepsiyon oranlarında ise istatistiki açıdan önemlik tespit edildi (%79.3 & %50.0; P=0.011). Alınan verilerden, vaginal akıntı skor sayısı azaldıkça, konsepsiyon oranının arttığı belirlense de, yapılan korrelasyon analizinde, vaginal akıntı skoru ve konsepsiyon oranı arasında anlamlı bir ili?kinin olmadığı tespit edildi (P>0.05). Sunulan bu çalı?manın sonuçlarına göre, üreme sezonu dı?ında kısa süreli progestagen ve PMSG kombinasyonu uygulanan koyunlarda, protokole immunmodülatör ilavesinin, östrüs oranı ve vaginal akıntı skorları üzerine etkili olmadığı, ancak konsepsiyon oranında önemli derecede bir artı? meydana getirdiği sonucuna varıldı.
