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    Effects of microencapsulated and non-encapsulated aronia extract on serum lipid profile and liver histology in Sprague-Dawley rats fed a high fat diet
    (Polish Society Magnesium Research, 2024) Koc, Serim Tuna; Kok, Suleyman; Ersoy, Onur; Atalay, Sertac
    The aim of this study was to determine the biofunctional effects of aronia extract and its microencapsulated form on lipid metabolism and liver tissue in rats fed a high-fat diet. In the study, 42 male Sprague-Dawley rats aged 10 weeks were used. The rats were divided into 6 groups, with 7 animals in each experimental group. The experimental groups were as follows: 1 - standard diet control (CON), 2 - high fat diet control (HF), 3 - HF + 400 mg kg(-1) aronia extract (HF400E), 4 - HF + 200 mg kg(-1) aronia extract (HF200E), 5 - HF + 400 mg kg(-1) aronia encapsulated (HF400C), and 6 - HF + 200 mg kg(-1) aronia encapsulated (HF200C). From the 10(th) week to 20(th) week, rats were fed with HF diet for 10 weeks except (CON). At the end of the 20(th) week, rats fed HF were administered aronia extract and its encapsulated form (200-400 mg kg(-1)) by oral gavage for 6 weeks. After six weeks of treatment, biochemical analyses were performed in blood and tissue samples of the rats. Liver histology was evaluated. As a result of the study, it was determined that the high-fat diet significantly increased serum ALT, AST, TC, TG and LDL-C levels and hepatic MDA levels, whereas administration of HF400E to hyperlipidaemic rats caused a significant decrease in the levels of these parameters. Furthermore, histopathological analysis of liver sections revealed that the HF400E treatment also protected against liver injury. These results indicated that HF400E improved lipid profiles, inhibited lipid peroxidation and played a protective role against liver injury in hyperlipidaemic rats. The lack of a significant effect of the encapsulation of aronia may be due to the short duration of treatment. Thus, future studies should be carried out for longer periods (>6 weeks) and at higher doses.
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    Gelatins derived from aronia-supplemented fish diets: Structural effect and molecular simulation
    (Elsevier, 2025) Kaynarca, Gulce Bedis; Yagcilar, Cretin; Kamer, Deniz Damla Altan; Gumus, Tuncay; Cretin, Ismail; Koc, Serim Tuna
    Fish gelatin, a sustainable substitute for mammalian gelatin, frequently exhibits weaker gel strength and thermal stability, limiting its industrial uses. This study investigated an in vivo method to improve functional characteristics by supplementing Nile tilapia diets with Aronia extract. The control diet (A0) contained no Aronia extract, while the remaining four diets consisted of commercial pelleted feed enriched with 250 mg/kg (A250), 500 mg/kg (A500), 750 mg/kg (A750), and 1000 mg/kg (A1000) of Aronia extract. The gelatin samples revealed thermo-reversible behavior with increasing temperature. A250 exhibited the highest melting temperature of 29.65 degrees C, compared to 27.43 degrees C for A0. The gelation temperature for A250 was 17.56 degrees C, indicating a relatively stable gelatin structure. The elastic modulus (G') was the highest in A250, suggesting an improved gel network compared to the other samples. The gelation rate constant (kgel) was highest in A250 (540.67 Pa), followed by A750 (447.32 Pa), A500 (393.85 Pa), and A1000 (370.97 Pa), compared to 391.15 Pa for A0. The gel strength was improved, with A250 showing the highest value at 133.9 g, followed by A750, A1000, and A500, while A0 was 102.1 g. The glass transition temperatures (Tg) for A250, fish gelatin (FG), bovine gelatin (BG), and A0 were 76.72 degrees C, 74.31 degrees C, 70.71 degrees C, and 73.52 degrees C, respectively. Molecular docking studies revealed strong binding interactions between A250 and phenolic compounds, which contributed to the observed structural enhancements. These findings suggest that supplementing fish diets with Aronia extract can substantially enhance gelatin quality, offering a promising alternative to traditional gelatin sources.