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    Azaindole-BODIPYs: Synthesis, fluorescent recognition of hydrogen sulfate anion and biological evaluation
    (Pergamon-Elsevier Science Ltd, 2019) Kesan, Gurkan; Topaloglu, Burcu; Özcan, Emrah; Kazan, Hasan Huseyin; Ecik, Esra Tanriverdi; Şenkuytu, Elif; Cosut, Bunyemin; Kandemir, Hakan
    The synthesized and sensing capability of two novel azaindole substituted mono and distyryl BODIPY dyes against bisulfate anion were reported. Structural characterizations of the targeted compounds were conducted by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, H-1 and C-13 NMRspectroscopies. Photophysical properties of the azaindole substituted BODIPY compounds were investigated employing absorption and fluorescence spectroscopies in acetonitrile solution. It was found that the final compounds 3 and 4 exhibited exclusively selective and sensitive turn-off sensor behavior on HSO4- anion. Additionally, the stoichiometry ratio of the targeted compounds to bisulfate anion was measured 0.5 by Job's method. Also, density function theory was performed to the optical response of the sensor for targeted compounds. Furthermore, the cytotoxicity of Azaindole-BODIPYs was examined against living human leukemia K562 cell lines. (C) 2019 Elsevier B.V. All rights reserved.
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    Meso-piperidine linked bodipys: Synthesis, fluorescent properties and biological evaluation
    (Elsevier Science Bv, 2019) Ecik, Esra Tanriverdi; Kazan, Hasan Huseyin; Şengül, İbrahim Fazıl; Kandemir, Hakan; Cosut, Bunyemin
    The synthesis and characterization of meso-piperidine linked Bodipy starting from 4-(2-(piperidine-1-yl)ethoxy) benzaldehyde was described. Meso-piperidine linked Bodipy was subsequently used for the construction of distyryl-piperidine-Bodipy and distyryl-morpholine-Bodipy via Knoevenagel type reaction. The photophysical properties including molar extinction coefficient, fluorescence lifetime and fluorescence quantum yield of Bodipys were investigated in ethanol solution. The targeted compounds were also assessed in live cell imaging and cytotoxicity studies by using breast cancer cell line, MCF-7 in vitro.