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    Do Peripheral and Extra Musculoskeletal Manifestations Have An Impact on Biologic Dmard Prescribing Patterns in Axial Spondyloarthritis: the Results of Treasure Experience
    (Bmj Publishing Group, 2021) Ediboglu, E. Durak; Solmaz, Duygu; Karadağ, Ömer; Pehlivan, Yavuz; Çınar, M.; Ertenli, Ali İhsan; Akar, Servet; Mercan, Rıdvan
    [No Abstract Available]
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    Genotypic characterization of meat-type lambs expressing the callipyge gene in Turkey: I. Carcass characteristics and retail yield
    (TUBITAK, 2022) Esen, Vasfiye Kader; Esen, S.; Karadağ, Ömer; Önenç, Alper; Elmacı, C.
    This study is set out to evaluate the effects of callipyge (CLPG) gene, attributed to sheep affecting growth and meat quality, on carcass and sensory trait of most preferred meat-type lamb (Kivircik, Karacabey Merino, Ramliç, German Black-Head Mutton × Kivircik, Hampshire Down × Merino) in the western part of Turkey. Two datasets were used: (i) 177 lambs (66 males, 111 females) to determine genotype and allele frequencies; (ii) 48 genotypically identified male lambs for the assessment of carcass and meat sensory quality. It was found that homozygous (NN) and heterozygous (MN) conditions of the CLPG gene were observed in all sheep breeds, except Ramliç which exhibits only NN. No significant differences were observed in CLPG genotypes for slaughter weight, cold carcass weight, and cold dressing percentage (p > 0.05). On the other hand, the effect of genotype on neck percentage was significant (p < 0.01), and lambs expressing CLPG genotype (MN) had a higher neck percentage. Not significantly, but numerically the MN genotype had a higher percentage of the shoulder, rack, and leg than the NN genotype, while the NN genotype had a higher percentage of loin (p > 0.05). Similarly, the effect of genotype on meat quality assessment was not significant (p > 0.05); however, shear force, water holding capacity, and cooking loss of the NN genotype were higher than the MN genotype. Indeed, no interaction between genotype and time was observed on the color parameter of the Longissimus thoracis et lumborum muscle at various storage periods (p > 0.05). The findings suggest that all meat-type sheep breeds (except Ramliç) were polymorphic, suggesting that heterozygous individuals who received the CLPG mutation from the sire should be adopted in selection programs to improve carcass traits. © 2022 TUBITAK. All rights reserved.
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    Short Term Efficacy of Tumor Necrosis Factor Inhibitors in Patients with non-radiographic Axial Spondylarthritis and ankylosing Spondylitis; Results from Turkbio Registry.
    (Wiley-Blackwell, 2014) Çetin, Pınar; Kalyoncu, Umut; Kisacik, Bunyamin; Sarı, İsmail; Solmaz, Dilek; Karadağ, Ömer; Akkoç, Nurullah
    [No Abstract Available]
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    The First Effect of COVID-19 Pandemic on Starting Biological Disease Modifying Anti-Rheumatic Drugs: Outcomes from the TReasure Real-Life Database
    (Aves, 2022) Kanıtez, Nilüfer Alpay; Kiraz, Sedat; Dalkılıç, Ediz; Kimyon, Gezmiş; Mercan, Rıdvan; Karadağ, Ömer; Beş, Cemal; Mercan, Rıdvan
    Objective: The coronavirus disease 2019 pandemic has been resulting in increased hospital occupancy rates. Rheumatic patients cannot still reach to hospitals, or they hesitate about going to a hospital even they are able to reach. We aimed to show the effect of the first wave of coronavirus disease 2019 pandemic on the treatment of biological disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis or spondyloarthritis. Methods: Patients were divided into three groups as follows: pre-pandemic (Pre-p: starting on biological disease-modifying anti-rheumatic drug therapy for the first time within 6 months before March 11, 2020); post-pandemic A (Post-p A: starting on biological disease-modifying anti-rheumatic drug therapy for the first time within the first 6 months after March 11, 2020); post-pandemic B (Post-p B: starting on biological disease-modifying anti-rheumatic drug therapy for the first time within the second 6 months). Results: The number of rheumatoid arthritis patients in the Post-p A and B groups decreased by 51% and 48%, respectively, as compared to the Pre-p group similar rates of reduction were also determined in the number of spondyloarthritis patients. The rates of tofacitinib and abatacept use increased in rheumatoid arthritis patients in Post-p period. Conclusion: The number of rheumatoid arthritis and spondyloarthritis patients starting on biological disease-modifying anti-rheumatic drugs for the first time decreased during the first year of the coronavirus disease 2019 pandemic.
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    Tuberculin skin test before biologic and targeted therapies: does the same rule apply for all?
    (Springer Heidelberg, 2022) İlgen, Ufuk; Karadağ, Ömer; Emmungil, Hakan; Küçükşahin, Orhan; Koca, Süleyman Serdar; Erden, Abdulsamet; Kalyoncu, Umut; Mercan, Rıdvan
    This study aimed to compare Tuberculin Skin Test (TST) and QuantiFERON (R)-TB Gold In-Tube (QFT-GIT) test in rheumatoid arthritis (RA) and spondyloarthritis (SpA) patients scheduled for biological and targeted synthetic disease modifying anti-rheumatic drugs (DMARDs) in a Bacillus Calmette-Guerin-vaccinated population. Adult RA (n = 206) and SpA (n = 392) patients from the TReasure database who had both TST and QFT-GIT prior to initiation of biological and targeted synthetic DMARDs were included in the study. Demographic and disease characteristics along with pre-biologic DMARD and steroid use were recorded. The distribution of TST and performance with respect to QFT-GIT were compared between RA and SpA groups. Pre-biologic conventional DMARD and steroid use was higher in the RA group. TST positivity rates were 44.2% in RA and 69.1% in SpA for a 5 mm cutoff (p < 0.001). Only 8.9% and 15% of the patients with RA and SpA, respectively, tested positive by QFT-GIT. The two tests poorly agreed in both groups at a TST cutoff of 5 mm and increasing the TST cutoff only slightly increased the agreement. Among age, sex, education and smoking status, pre-biologic steroid and conventional DMARD use, disease group, and QFT-GIT positivity, which were associated with a 5 mm or higher TST, only disease group (SpA) and QFT-GIT positivity remained significant in multiple logistic regression. TST positivity was more pronounced in SpA compared to that in RA and this was not explainable by pre-biologic DMARD and steroid use. The agreement of TST with QFT-GIT was poor in both groups. Using a 5 mm TST cutoff for both diseases could result in overestimating LTBI in SpA.