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    Effects of sodium arsenite on the some laboratory signs and therapeutic role of thymoquinone in the rats
    (Verduci Publisher, 2015) Aras, S.; Gerin, Fethullah; Aydın, B.; Ustunsoy, S.; Şener, Ümit; Turan, Bünyamin Cüneyt; Armutcu, F.
    OBJECTIVE: Serious health problems in humans are caused by arsenic (As) exposure, which is wide spread in the environment. Sodium arsenite (SAs), capable of inducing macromolecular damage is evaluated for its damaging effect in the blood vessels, liver and kidneys of Wistar rats. This study was undertaken to investigate the ameliorative effects of thymoquinone on SAs-induced oxidative and inflammatory damages in the serum of male Wistar rats. MATERIALS AND METHODS: Wistar Albino rats divided into three groups of nine rats each were administered to controls saline (10 mg/kg), SAs (10 mg/kg), and SAs plus thymoquinone (10 mg/kg/day) for two weeks orally. Biochemical tests were analyzed by a otoanalyzer; nitric oxide levels specthrophometrically, and cytokines were measured by ELISA method in the rat serum samples. RESULTS: Inflammatory cytokines and some biochemical variables were found to be increased in the SAs group compared to control group. On the other hand, thymoquinone supressed these laboratory signs, which are thought to be the characteristic signs of SAs toxicity, most probably by its ameliorative effects including anti-inflammatory and antioxidant properties. CONCLUSIONS: From the results obtained, thymoquinone mitigates SAs-induced adverse effects in the serum of rats, which suggest that it may attenuate inflammation implicated in endotelial dysfunction.
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    Evaluation of the Prevalence of Thyroid Autoantibodies in Patients with Alopecia Areata
    (Wiley-Blackwell, 2016) Gerin, Fethullah; Albayrak, Hülya; Soydan, Zekeriya; Şener, Ümit; Yanık, Mehmet Emin; Erboğa, Mustafa; Gürel, Ahmet
    [No Abstract Available]
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    The Effects of Ferulic Acid Against Oxidative Stress and Inflammation in Formaldehyde-Induced Hepatotoxicity
    (Springer/Plenum Publishers, 2016) Gerin, Fethullah; Erman, Hayriye; Erboğa, Mustafa; Şener, Ümit; Yılmaz, Ahsen; Seyhan, Hatice; Gürel, Ahmet
    This study was designed to elucidate the protective effects of ferulic acid (FA) on formaldehyde-induced hepatotoxicity by measuring some routine biochemical parameters, cytokine levels, and oxidative stress-related parameters in addition to YKL-40 in male Wistar albino rats. Tissue superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activities, and tissue malondialdehyde (MDA) levels were measured. Also, serum YKL-40, TNF-alpha, IL-6, IL-1 beta, IL-8, total protein, albumin, total bilirubin concentrations, and AST, ALT, ALP, and LDH activities were measured. Histological specimens were examined in light microscopy. Formaldehyde significantly increased tissue MDA, and serum cytokine levels and also decreased activities of antioxidant enzymes. FA treatment decreased MDA and cytokine levels and increased activities of antioxidant enzymes. FA also alleviated degeneration due to formaldehyde toxicity. We suggested that FA can be used as a promising hepatoprotective agent against formaldehyde toxicity because of the obvious beneficial effects on oxidative stress parameters.
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    The Effects of Quercetin on Acute Lung Injury and Biomarkers of Inflammation and Oxidative Stress in the Rat Model of Sepsis
    (Springer/Plenum Publishers, 2016) Gerin, Fethullah; Şener, Ümit; Erman, Hayriye; Yılmaz, Ahsen; Aydın, Bayram; Armutcu, Ferah; Gürel, Ahmet
    Experimental studies indicate that sepsis causes remote organ injury although the molecular mechanism has not been clearly defined. In this report, the role of oxidative damage, and inflammation on lung injury, following sepsis model by cecal ligation and puncture, and the effects of quercetin, antioxidant, and anti-inflammatory flavonoid, in the lung tissue were investigated. In the present study, we found that administration of single-dose quercetin before cecal ligation and puncture procedure, while markedly diminishing the levels of YKL-40 and oxidant molecules (xanthine oxidase (XO), nitric oxide (NO), and malondialdehyde (MDA)), increases the antioxidant enzymes levels. Quercetin is beneficial to acute lung injury by decreasing the levels of oxidative stress markers and increasing the antioxidant enzyme activities. Quercetin also causes a decrease in the serum levels of YKL-40 and periostin in the oxidative lung injury induced by the experimental sepsis model.