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    Investigation of the Levels of Blood MDA, GSH and Nitric Oxide Levels in Patients with Probable Alzheimer's Disease
    (2020) Güven, Aysel; Yıldız Dalgınlı, Kezban; Çulhaoğlu, Hacer; Huseyınoglu, Nergiz; İlhan Alp, Selen
    Aim: The main focus of this study is to determine blood malondialdehyde (MDA), Glutathione (GSH) and nitric oxide (NO) levels in patients with possible Alzheimer’s disease (AD).Material and Method: The study included 15 healthy persons and 15 Alzheimer’s patients aged between 65 and 79 living in Kars. Before taking blood samples from patients who were diagnosed with Alzheimer at Kafkas University Faculty of Medicine Neurology Service, they were applied Standardized Mini Mental State Examination (SMMSE) and Clinical Dementia Rating. In the next step, erythrocyte GSH and serum MDA, NO levels were determined.Results: The difference between healthy persons and Alzheimer’s disease group erythrocyte GSH (p<0.05) and serum MDA (p<0.01), NO (p<0.001) levels were statistically significant. MMSE scores were significantly lower than the control group (p<0.001).Conclusion: It was observed that AD caused lipid peroxidation and as a conclusion significantly increased the MDA, GSH and NO levels in the blood of Alzheimer patients. This study supports the theory that the brain is affected by increased oxidative stress in AD based on the data obtained.