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Öğe Acitretin-induced spiny follicular hyperkeratosis(Taylor & Francis Ltd, 2016) Yanık, Mehmet Emin; Erfan, Gamze; Albayrak, Hülya; Taşolar, Kaan; Albayrak, Şule; Gelincik, İbrahim; Kulaç, MustafaSpiny follicular hyperkeratosis (SFH) is follicular flesh-colored hyperkeratotic spicules that are linked to different situations including drug reactions. Previously suspected drugs are BRAF inhibitors and cyclosporine. We described a 51-year-old psoriasis patient with SFH who had been using acitretin.Öğe Alopesi Areata Hastalarında Nötrofil/Lenfosit Oranının ve Diğer İnflamatuar Parametrelerin Normal Popülasyon İle Karşılaştırılması(Selçuk Üniversitesi, 2016) Yanık, Mehmet Emin; Erfan, Gamze; Albayrak, Hülya; Kara, Pınar Sonat; Solmaz, Dilek; Kulaç, MustafaAmaç: Bu çalışmanın amacı; alopesi areata AA hastalarında nötrofil/lenfosit oranını NLR , Eritrosit sedimentasyon hızı ESR , C reaktif protein CRP gibi inflamatuar parametreleri normal populasyon ile kıyaslayarak bu parametrelerin AA hastalarında inflamasyonun şiddetini ölçebilecek bir marker olarak kullanılabilirliğini değerlendirmektir.Yöntem: Çalışmaya klinik olarak AA tanısı konmuş 234 hasta dahil edildi. 37 sağlıklı kişi alındı. Hasta dosyalarından lökosit, nötrofil ve lenfosit sayıları ile ESR ve CRP sonuçları kaydedildi. NLR ise hesaplanarak bulunup kaydedilmiştir. Bulgular: Hasta ve kontrol grubu arasında Lökosit, Nötrofil, ,Hb ve Esr değerleri ile NLR açısından anlamlı fark saptanmazken p>0.05 Lenfosit sayıları p=0,02 ve Crp PÖğe Alopesi areata hastalarında nötrofil/lenfosit oranının ve diğer inflamatuar parametrelerin normal popülasyon ile karşılaştırılması(2016) Yanık, Mehmet Emin; Erfan, Gamze; Albayrak, Hülya; Kara, Sonat Pınar; Solmaz, Dilek; Kulaç, MustafaAmaç: Bu çalışmanın amacı; alopesi areata(AA) hastalarında nötrofil/lenfosit oranını (NLR), Eritrosit sedimentasyon hızı(ESR), C reaktif protein(CRP) gibi inflamatuar parametreleri normal populasyon ile kıyaslayarak bu parametrelerin AA hastalarında inflamasyonun şiddetini ölçebilecek bir marker olarak kullanılabilirliğini değerlendirmektir.Yöntem: Çalışmaya klinik olarak AA tanısı konmuş 234 hasta dahil edildi. 37 sağlıklı kişi alındı. Hasta dosyalarından lökosit, nötrofil ve lenfosit sayıları ile ESR ve CRP sonuçları kaydedildi. NLR ise hesaplanarak bulunup kaydedilmiştir. Bulgular: Hasta ve kontrol grubu arasında Lökosit, Nötrofil, ,Hb ve Esr değerleri ile NLR açısından anlamlı fark saptanmazken(p>0.05) Lenfosit sayıları(p=0,02) ve Crp( P <0.001) değeri AA hastalarında yüksek olduğu tesbit edilmiştir. Sonuç: Sonuç olarak AA hastalığında NLR değerinin kullanılabilecek bir belirteç olmadığı kanaatine varılmıştır. CRP'nin AA için kullanılabilir bir marker olduğunu gösterebilmek için daha geniş ölçekli çalışmalar yapmak gereklidir.Öğe Alopesi Areatalı hastaların hematolojik parametrelerinin normal populasyon ile karşılaştırılması(2016) Şener, Ümit; Yanık, Mehmet Emin; Erboğa, Mustafa; Albayrak, Hülya; Erfan, Gamze; Gürel, AhmetAmaç: Bu çalışmada, alopesi areatalı hastaların hematolojik parametrelerinin normal populasyonun hematolojik parametreleri ile karşılaştırılması ve olası değişikliklerin, farklılıkların saptanması amaçlanmıştır.Yöntem: Bu çalışma, geriye dönük olarak gerçekleştirildi. 2013-2015 Yıllarında Namık Kemal Üniversitesi, Araştırma ve Uygulama Merkezi, Deri ve Zührevi Hastalıklar Polikliniği'ne başvurmuş 18-65 yaş arasındaki, 50 (35 erkek, 15 kadın) Alopesi Areata tanısı almış hasta, 50 (35 erkek, 15 kadın) sağlıklı kontrol, çalışmaya dahil edildi. Hastalara ve kontrol grubuna ait hematolojik parametreleri, kayıtlardan öğrenildi. Bulgular: AA' lı hastalara ait eritrosit sayısı (RBC), hemoglobin miktarı (Hb), hematokrit (Htc) değerleri, total lökosit, nötrofil, lenfosit ve monosit sayılarının kontrol grubuna göre anlamlı derecede yüksek, eritrosit dağılım aralığı (RDW-CV) değerinin ise anlamlı derecede düşük olduğu görüldü (sırasıyla p<0,05, p<0,01, p<0,01, p<0,05, p<0,05, p<0,05, p<0,05, p<0,001). Bu parametreler, cinsiyete göre değerlendirildiğinde ise, AA' lı kadınlarda ve erkeklerde RDW-CV değerinin kontrol grubuna göre anlamlı derecede düşük olduğu (sırasıyla p<0,05, p<0,01) saptandı. AA' lı erkeklerde ise Hb ve Htc değerlerinin erkek kontrol grubuna göre anlamlı derecede yüksek olduğu (sırasıyla p<0,01, p<0,01), total lökosit, nötrofil, lenfosit ve monosit sayılarının erkek kontrol grubuna göre anlamlı derecede yüksek saptandı (sırasıyla p<0,01, p<0,05, p<0,01, p<0,05). Sonuç: Bu çalışmada, AA'lı hastalarda normal popülasyona göre eritrositer seride ve lökositer seride gözlenen değişiklikler, hem hematopoezde, hem de hücresel immunitede aktivite artışının olduğunu düşündürmektedir. Bu bulgular, AA hastalarda hematopoezi uyaran faktörlerin varlığına, bu hastalığın immun sistemi aktive ettiğine ve etiyolojisinde otoimmunitenin rol oynamakta olduğuna işaret etmektedir. Öte yandan, bu çalışmada bildirilen verileri destekleyecek yeni çalışmalara ihtiyaç bulunduğu kanaatindeyiz.Öğe Association between Pityriasis Rosea (PR) and HHV-6/HHV-7 Infection: Importance of Sample Selection and Diagnostic Techniques(Mdpi, 2024) Kurc, Mine Aydin; Erfan, Gamze; Kaya, Ayse Demet; Gulen, Dumrul; Oznur, Meltem; Yanik, Mehmet EminRecent studies have focused on the role of human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) in PR etiology with varying results. In our study, with the approach that the discrepancy between the results may be related to the different samples and techniques used, we aimed to clarify the etiology by examining tissue and plasma samples using molecular methods and evaluating the results together with serological parameters. Skin biopsies and plasma samples of twenty-five PR patients were tested to detect HHV-6 and HHV-7 DNA using calibrated quantitative real-time polymerase chain reaction (CQ RT-PCR). IgG and IgM antibodies against HHV-6 and HHV-7 were tested by enzyme-linked immunosorbent assay and indirect immunofluorescence. Of the patient group, 64% were positive for HHV-6 IgG without IgM positivity. HHV-6 DNA was present in seven tissue and ten plasma samples. HHV-7 positivity was 100% and 12% for IgG and IgM antibodies, respectively. HHV-7 DNA was detected in four tissue samples and one plasma sample. Patients with HHV-7 DNA-positive plasma and tissue samples had also HHV-7 IgM antibodies. In conclusion, our results seem to support the role of HHV-6/HHV-7 in the etiology of PR. To clarify the etiology of PR and avoid confusion, the collection of different biological materials simultaneously and the usage of CQ RT-PCR as a diagnostic technique are recommended.Öğe Association of colon adenomas and skin tags: coincidence or coexistence?(Verduci Publisher, 2014) Oran, Mustafa; Erfan, Gamze; Mete, Rafet; Yanık, Mehmet Emin; Yıldırım, Oğuzhan; Aydın, M.; Topçu, BirolOBJECTIVES: Skin tag (STs) are benign connective tissue tumors of the dermis. Some researchers have argued that there is a relationship between skin tag and colon polyps, although the physiopathological mechanisms underlying this relation were not well elucidated. In this study we aimed to investigate the co-existence of colonic adenomatous polyps and ST, additionally to shed light on the physiopathological mechanisms underlying this coincidence. PATIENTS AND METHODS: A total of 45 patients aged between 18 and 60 diagnosed with adenomatous colonic polyps and 45 sex, age, and socio-demographically matched subjects, had no polyps, were enrolled as the control group. Routine blood analysis of all participants, including serum glucose, total cholesterol, low-density lipoprotein cholesterol (LDL-C), (high-density lipoprotein cholesterol (HDL-C), triglyceride, insulin, IGF-1, and EGF, were performed. The chi-square and independent sample t or Mann Whitney U test were used to determine differences between groups. RESULTS: The number of participants with ST was significantly higher in the patient group (OR 7.067, p < 0.01). Serum levels of IGF-1 and EGF were statistically similar between the groups. In the subgroup analyses, no difference was found in serum levels of insulin, IGF-1, or EGF between patients with and without ST. However, higher serum levels of insulin and EGF were found in control subjects with ST (p < 0.01 and p < 0.01, respectively). For the entire study group, 67 participants had ST and 23 patients did not. Serum insulin, and IGF-1 were similar, while serum EGF levels were higher in patients with ST (p < 0.01). CONCLUSIONS: Findings of the present study may show a co-existence of colonic polyps and ST. Although previous studies have indicated that insulin resistance may play a role in the pathogenesis of both lesions in diabetic and obese patients, we found no indication of a relationship in nondiabetic and nonobese patients with increased levels of EGF in patients with ST, suggesting an alternative pathogenesis in this patient group.Öğe Atherosclerosis, some serum inflammatory markers in psoriasis(Edizioni Minerva Medica, 2014) Alpsoy, Şeref; Akyuz, A.; Erfan, Gamze; Akkoyun, Dursun Çayan; Topçu, Birol; Güzel, Savaş; Kulaç, MustafaAim. Psoriasis is an autoimmune inflammatory disease which is associated with increased inflammatory markers and atherosclerosis. We wanted to investigate whether there is a relationship between some inflammatory markers and subclinical atherosclerosis markers. Methods. We studied 60 psoriasis patients and 50 healthy controls. Demographic, biochemical parameters, C3, C4, d-dimer, CRP, fibrinogen and YKL-40 (human cartilage glyco-protein-39) levels were measured. After measuring carotid intima-media thickness (cIMT) and aortic elasticity parameters such as aortic strain, (beta) stiffness index and compliance, statistical comparisons were done. Results. Patients with psoriasis had significantly higher diastolic blood pressure, CRP, fibrinogen, C3, uric acid levels, beta-stiffness index, and cIMT values than the control group. cIMT was correlated with CRP, YKL-40 and psoriasis area and severity index (PASI) score (r=0.219, P=0.038; r=0.225, P=0.033 and r=0.275, P=0.034). Aortic strain (%), aortic compliance and aortic stiffness index were correlated with C3 (r=-0.349, r=-0.526 and r=0.235) and fibrinogen (r=-0.354, r=-0.275 and r=0.289), all P values <0.05, but not with PASI score. The presence of psoriasis was related to aortic strain (beta +/- SE: -2.055 +/- 0.861, P=0.019) and beta-stiffness index (beta +/- SE: 2.934 +/- 1.143, P=0.012). Conclusion. Serum C3, CRP, fibrinogen and YKL-40 levels are elevated as well as increased cIMT and impaired aortic elasticity in psoriasis. CRP, YKL-40 and PASI score are correlated with cIMT. Increased serum C3 and fibrinogen levels correlate negatively with aortic strain and aortic compliance, and correlate positively with the beta-stiffness index.Öğe Caga Strain of Helicobacter Pylori in Recurrent Aphtous Somatitis Patients Without Dyspeptic Symptoms: Response to Eradication Therapy(Carbone Editore, 2014) Erfan, Gamze; Mete, Rafet; Oran, Mustafa; Yanık, Mehmet Emin; Güneş, Hayati; Kaya, Şule; Topçu, BirolHelicobacter pylori (HP) play a role as an etiological factor of soine dermatological diseases such as rosacea and Behcet disease. Recurrent aphtus stomatitis (RAS) is the most common mucosal disease with unknown etiology. Several microbial agents such as HP also have been proposed as causative factors for this disease. Although some of the studies do not support a strong association between HP and RAS, the relationship might differ when the virulence of the infecting strains are examined. The cytotoxin-associated gene A (CagA) is one of the virulence factors of HP and has impact in some of the extra gastrointestinal dermatological diseases such as rosacea. In this study; the seroprevelance of CagA of non-dyspeptic RAS patients and the eradication treatment response in CagA positive and negative RAS patients were examined. In 87 RAS patients and 72 healthy volunteers; 43.6% of RAS patients and 25% of control subjects were CagA (+). The number of CagA (+) patients were significantly higher in RAS group. (OR: 3.61, 95%CI: 1.21-10.7, p=0.01). Out of 45 HP (+); 32 (80%) of patients who underwent eradication treatment assessed three months after treatment. In CagA (+) RAS patients; composite index score of RAS after eradication was significantly lower than before treatment (p 0.01) but in CagA (-) RAS patients statistical analysis revealed no difference (p= 0.11). The CagA strain of HP is significantly higher even in non-dyspeptic RAS patients than healthy cases. The eradication treatment in these patients with HP and CagA seropositivity improves symptoms of RAS.Öğe Chemerin and calprotectin levels correlate with disease activity and inflammation markers in psoriasis vulgaris(Elsevier Taiwan, 2015) Güzel, Savaş; Erfan, Gamze; Kulaç, Mustafa; Güzel, Eda Çelik; Küçükyalçın, Volkan; Kaya, Şule; Kızıler, Ali RızaBackground: Psoriasis is a chronic inflammatory dermatosis that affects about 2-3% of the general population. We aimed to investigate the relationship between serum chemerin and calprotectin levels and the inflammatory markers that can lead to oxidative damage. Methods: Fifty patients with psoriasis and 30 healthy controls were included in the study. Levels of chemerin and calprotectin were measured in addition to levels of C-reactive protein, the erythrocyte sedimentation rate, and the white blood cell count to evaluate inflammation. Results: According to our findings, chemerin and calprotectin levels in the patient group were significantly higher than in the control group (p <0.01 and p < 0.001. respectively). Patients with psoriasis were divided into three groups based on the Psoriasis Area and Severity Index: mild, moderate, and severe. The chemerin levels in the severe and moderate groups were significantly higher than in the mild group (p < 0.01 and p < 0.05, respectively). The calprotectin levels in the severe psoriasis group were also significantly higher than in the mild group (p < 0.05). Similarly, the erythrocyte sedimentation rate and levels of fibrinogen and C-reactive protein were significantly higher in patients with psoriasis than in the control group (p < 0.05, p <0.01. and p < 0.001, respectively). Stepwise regression analysis was used to assess the individual contributing factors. Among these contributing factors, the chemerin levels were observed to be positively correlated with both the Psoriasis Area and Severity Index (R-2 = 0.111) and the calprotectin level (R-2 = 0.445). Calprotectin was observed to be positively correlated with both the C-reactive protein (R-2 = 0.119) and chemerin levels (R-2 = 0.315). Conclusion: The chemerin and calprotectin levels in patients with psoriasis showed that there is an inflammatory process in psoriasis and that these markers are useful indicators of the severity of psoriasis. (C) Copyright 2014, Taiwanese Dermatological Association. Published by Elsevier Taiwan LLC. All rights reserved.Öğe Cutaneous Side Effects of Single Versus Combined BRAF Inhibitors: A Comment to Erfan et al. Reply(Acta Dermato-Venereologica, 2017) Erfan, Gamze; Carrera, Cristina; Malvehy, Josep; Puig, Susana[No Abstract Available]Öğe Decreased ovarian reserve in female Sprague-Dawley rats induced by isotretinoin (retinoic acid) exposure(Elsevier Sci Ltd, 2013) Abalı, Remzi; Yüksel, Mehmet Aytaç; Aktaş, Cevat; Çelik, Cem; Güzel, Savaş; Erfan, Gamze; Şahin, ÖnderIsotretinoin is a retinoid widely used for the treatment of severe nodulocystic acne. Although it has broad side effects, there is no well-designed study about its effects on the ovary. This study investigated possible toxic effects of isotretinoin on female gonads. A total of 30 female rats were randomly divided into three equal groups according to the dose of isotretinoin they were administered: 0 mg/kg/day (group 1), 7.5 mg/kg/day (group 2) or 15 mg/kg/day (group 3). Thirty days after the treatment, the effects of isotretinoin on the ovaries were evaluated with serum anti-Mullerian hormone (AMH) concentrations, apoptosis by TUNEL assay and immunohistochemical observations by proliferating cell nuclear antigen (PCNA). The percentage of atretic follicles was calculated for each stage of folliculogenesis. The serum AMH concentrations were found to be lower in both isotretinoin groups. The percentage of atretic follicles in both isotretinoin groups was higher than the control. The number of PCNA-positive granulosa cells was decreased in the isotretinoin groups. The number of ovarian follicles with apoptotic granulosa cells was increased in the experimental groups. These data are the first to identify that exposure of isotretinoin may be responsible for decreased ovarian reserve and toxic effects on rat ovaries. RBMOnline Crown Copyright (C) 2013. Published by Elsevier Ltd. All rights reserved.Öğe Decreased ovarian reserve in female Sprague-Dawley rats induced by isotretinoin exposure(Oxford Univ Press, 2013) Abalı, Remzi; Yüksel, Mehmet Aytaç; Aktaş, Cevat; Çelik, Cem; Güzel, Savaş; Erfan, Gamze; Şahin, Önder[No Abstract Available]Öğe Dermatological Aspect of Labial Fusion: a Prospective Study(2019) Erfan, Gamze; Varol, Gamze; Yeşildağ, EbruAim:Labial fusion is a common condition in prepubertal girls and has several complications. Some dermatological conditions were reported as etiologic factor for this disease. The aim of this study is to evaluate the etiological factors of labial fusion in children through a dermatologic view and to compare the socio-demographic, and environmental data of patients with healthy children.Materials and Methods:In this cross sectional prospective study,23 patients with labial fusion and 49 age-sex matched healthy subjects were questioned and examined from dermatological aspect and assessed by aquestionnaireResults:In the control group; 35 % of mothers graduated from university. In children with labial fusion 35% and 26% of mothers graduated from primary school and university, respectively. The atopic family history and history of atopic diseases of patients were higher in labial fusion group when compared with healthy controls. (p<0.001, p <0.001) There were complaints of pre-erythematous lesions with a mean of 1.26±1.32 (median: 1.00) weeks before labial fusion in 60.9% (n:14) of patients with labial fusion. The alcohol based baby wipes usage was higher in group with labial fusion (p = 0.035).Conclusion:Labial fusion can be diagnosed in children of mothers with lower grade education, with family and personal atopic history and diseases, and frequent usage of alcohol based baby wipes. Also erythema in genital area could need follow-up in first month of visit for prevention or early diagnosis of labial fusion.Öğe Development of Cutaneous Toxicities During Selective Anti-BRAF Therapies: Preventive Role of Combination with MEK Inhibitors(Acta Dermato-Venereologica, 2017) Erfan, Gamze; Puig, Susana; Carrera, Cristina; Arance, Ana; Gaba, Lydia; Victoria, Ivan; Malvehy, Josep[No Abstract Available]Öğe Distinct temperament and character profiles in first onset vitiligo but not in alopecia areata(Wiley, 2014) Erfan, Gamze; Albayrak, Yakup; Yanık, Mehmet Emin; Öksüz, Özden; Tasolar, Kaan; Topçu, Birol; Ünsal, CüneytAlopecia areata (AA) and vitiligo (V) are diseases that are correlated with psychiatric disorders before, during and after diagnosis. The Temperament and Character Inventory (TCI) is a well-established approach for investigating personality traits in various psychosomatic diseases. The aim of this study is to compare and investigate the differences in the TCI between patients with first onset AA, patients with V and healthy controls (HC). Participants in the study included 42 patients with first onset AA, 50 adult patients with V and 60 HC who had no history or diagnoses of psychiatric or dermatological disorders. All participants were assessed with the TCI and the Dermatology Life Quality Index (DLQI). Among the temperament traits, the extravagance, disorderliness and total novelty-seeking scores were lower, and the worry and pessimism scores were higher in patients with V compared with patients with AA and the HC. The mean score of the enlightened second nature and the total self-directedness score of the character traits were higher in patients with V compared with patients with AA and the HC group. In the AA group, there was a negative correlation only between the reward dependence total score and the DLQI score. This study suggests that patients with first onset V have a distinct temperament, such as being unenthusiastic and unemotional, and character profiles, such as worry and pessimism, independent of their psychiatric comorbidities, and patients with AA do not have a different personality from the non-affected population.Öğe Distribution and antifungal susceptibility profiles of candida species isolated from dermatomycosis patients(2024) Kurç, Mine Aydın; Kaya, Ayşe Demet; Erfan, Gamze; Albayrak, ŞuleAims: Superficial mycoses are the most common dermatological diseases worldwide, and the causes are becoming increasingly resistant to antifungal agents used in treatment. The aim of our study was to identify the yeast species causing superficial mycoses and determine their susceptibilities to some antifungal agents. Methods: Skin and nail scraping samples obtained from 726 patients with suspected superficial fungal infection were collected and examined by direct microscopy and culture. Isolates were identified by conventional methods and API ID32 C (Biomeriux, France) commercial kits. The minimum inhibitory concentrations (MIC) of isolates against itraconazole, miconazole, nystatin, and terbinafine antifungals were determined by microdilution method. Results: A total of 59 yeasts were isolated from the samples. The most frequently isolated species were Candida glabrata (n=31, 52.54%), Candida guillermondii (n=9, 15.25%), and Candida albicans (n=7, 11.86%). In terms of infection sites, the most common involvement was observed in the foot (n=39, 66.1%) and nails (n=16, 27.1%). In terms of their antifungal susceptibilities, the highest resistance was detected against terbinafine (35.6%) and itraconazole (33.9%). Multidrug resistance was observed among strains of the Candida species (n=17, 28.8%). Conclusion: The most striking results of this study can be summarized as high rates of Candida glabrata isolation, increase in resistance rates, and a prevalence of 28.8% multidrug resistance. This data once again emphasize the importance of isolation, identification, and antifungal susceptibility testing in the diagnosis and effective treatment of superficial mycoses.Öğe Early Cosmetic Results and Midterm Follow-up Findings of Rhinophyma Patients Treated With High-Frequency Electrosurgery and a Discussion on the Severity Assessment of the Disease(Sage Publications Inc, 2017) Goktay, Fatih; Erfan, Gamze; Çelik, Nil Su; Öztürk, Canan; Doruk, Tuba; Albayrak, Hülya; Albayrak, Şule; Yanık, Mehmet EminBackground: Different methods can be used in the surgical treatment of patients with rhinophyma. There are limited numbers of reports on high-frequency electrosurgery treatment. In addition, an efficient scoring system is required to evaluate severity of the disease in clinical progress and recurrence after treatment. Objectives: We evaluated patients with rhinophyma who were treated with high-frequency electrosurgery and discussed the methods used to assess severity of the disease. Methods: Data and photos of 13 patients were retrospectively evaluated and scored via 2 different forms of the rhinophyma severity index. Results: Median rhinophyma severity index scores of patients at first visits were significantly higher than those at second and third visits (P = .002 and P = .002, respectively). Likewise, median modified rhinophyma severity scores of patients at first visits were significantly higher than those at second and third visits (P = .001 and P = .001, respectively). Also, there was a strong positive correlation between these 2 assessment methods (r = 0.838, P < .001). Conclusions: The rhinophyma severity assessment methods used in this study are positively correlated. High-frequency electrosurgery seems to be a procedure that is safe, effective, and relatively cost-effective in the treatment of rhinophyma lesions.Öğe Effect of left ventricular diastolic function of psoriasis(Aves Press Ltd, 2014) Akkoyun, Dursun Çayan; Alpsoy, Şeref; Erfan, Gamze; Yanık, Mehmet Emin; Akyüz, AydınThe objective of our study was to evaluate the diastolic left heart functions of patients with no known cardiovascular disease via tissue Doppler imaging method. 50 psoriasis patients along with 30 healthy individual controls were included in the study. When the psoriasis group was compared with the control group, a decrease in left ventricular early filling time (71.8 +/-+/- 4.9 versus 81 +/-+/- 3.8, P<0.05) and increase in atrial filing [67.5 (44-93) versus 60 (46-96), P<0.05] as well as decrease in E/A ratio [1.14 (0.64-1.8) versus 1.27 (0.74-1.67), P<0.05] were observed in psoriasis patients; whereas a significant increase was not observed in the deceleration time [184 (102 - 261) versus 172 (146 - 261), P>0.05], Whereas isovolumetric relaxation time was determined to be longer [95 (55 -1 21) versus 89 (39 1 14), P<0.05] in a statistically significant manner in the psonrisis group. When the psoriasis patients were compared with the control group, septal E' [10.1 (6 - 17) versus 11 (7 - 16)] and septal E'/A' [0.9 (0.55 - 2) versus 1.42 (0.53 - 2.67)] along with lateral E' [11 (6 - 19) versus 14 (8 - 20)] and lateral E'/A' [1.09 (0.62 - 2.67) versus 1.76 (0.73 - 2.5)] were determined to be lower (P<0.05). Septal A' was determined to be higher in the psoriasis group. Our study has put forth the relationship between psoriasis and the detenriration of the functions in left ventricular diastolic functions.Öğe Helicobacter Pylori Pozitif Alopesi Areata ve Vitiligo Hastalarında Cag-A İlişkisi(2015) Erfan, Gamze; Oran, Mustafa; Mete, Rafet; Güneş, Hayati; Yanık, Mehmet Emin; Albayrak, Hülya; Taşolar, Mustafa Kaan; Murat Aydın, Ayşe; Topçu, Birol; Kulaç, MustafaAmaç: Helicobacter Pylori (HP) ile bazı dermatolojik hastalıklar arasında ilişki kurulurken, alopesi areata (AA) ve HP arasında çelişkili veriler mevcuttur. Bu çelişkili sonuçların nedeni, HP'nin virulansından sorumlu faktörlerden biri olan Cag-A (sitotoksin ilişkili gen ürünü A) olabilir. Vitiligoda ise HP'nin muhtemel rolü hakkında tıbbı literatürde çok az sayıda çalışma bulunmaktadır. Literatürde tespit edilebildiği kadarıyla Cag-A (+) suşlarının rolünün saptandığı sadece bir çalışma bulunmaktadır. Yöntem: Altmış AA ve 52 vitiligo tanısı almış, dispepsi, eşlik eden otoimmün hastalıklar ve diğer enfeksiyonlar açısından hikâye, belirti, tanı ve tedavileri olmayan hastalar ve 60 sağlıklı bireyde HP stool antijeni ve serumlarında Cag-A seroprevelansı ELİSA kullanılarak incelendi. Hastalık şiddetleri AA grubunda alopesi şiddet ölçeği (SALT) skoru ve vitiligo grubunda ise "dokuzlar kuralı" ile ölçüldü ve HP, Cag-A pozitifliği ile ilişkisi karşılaştırıldı. Bulgular: AA grubunda 43 (%71,7), vitiligo grubunda 26 (%50) hastada HP (+)'liği saptandı. Bu hastalardan AA hastalarında Cag-A (+)'liği 26 (%60,4), vitiligo hastalarında 17 (%65,3) kişide saptandı. AA hastaları ile kontrol grubu karşılaştırıldığında, HP (+)'liği ve Cag-A (+)'liği AA hastalarında belirgin olarak yüksek sayıda saptanırken (p<0.05), vitiligo hastaları ile kontrol grubu karşılaştırıldığında ise HP (+)'liği ve Cag-A (+)'liği ile herhangi bir fark ve hastalık şiddeti açısından ilişki saptanmadı. Sonuç: Cag-A (+) HP suşları sağlıklı bireylere göre dispeptik olmayan AA hastalarında yüksek orandadır ancak vitiligo hastalarında bu yükseklik ve hastalık şiddetleri ile ilişki tespit edilememiştir.Öğe Investigation of the serum brain-derived neurotrophic factor in patients with alopecia areata: A preliminary study(Istanbul Universitesi, 2014) Erfan, Gamze; Albayrak, Yakup; Emin Yanık, M.; Ünsal, Cüneyt; Günes, H.; Kulaç, Mustafa; Kuloğlu, MuratObjectives: Alopecia areata (AA) is an asymptomatic hair loss; with mostly single, well-defined patches and in-group of non-scarring alopecia. There have been numerous studies that reported high percentages of psychiatric comorbidity in patients with alopecia areata. Beside these studies, to our knowledge there has been no study that researched a psychiatric biomarker such as brain-derived neurotrophic factor (BDNF) in first onset alopecia areata patients. Method: This study was conducted in Namık Kemal University Medical Faculty, Departments of Dermatology and Psychiatry between March 2013 and September 2014. After inclusion and exclusion criteria, 60 patients with first onset AA who have no current and past psychiatric disorder and 60 age-sex matched healthy subjects were compared in terms of serum brain-derived neurotrophic factor. Results: The age and female /male ratio were found to be insignificant between groups. The mean values of serum BDNF were 2.13±1.71 ng/dl and 2.32±1.93 ng/dl in AA group and in healthy control group respectively. The mean BDNF level was found to be similar between groups (t=2.76, p=0.61). Conclusions: According to our knowledge, this study is the first to compare serum BDNF between patients with first onset alopecia areata and healthy subjects. Our study might indicate that patients with alopecia areata have similar serum BDNF levels compared with normal population. Nonetheless, further studies are needed to support our preliminary results. © 2014, Istanbul Universitesi. All rights reserved.
