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    Characterization and Lidocaine Release Behavior of Chitosan/ Sodium Alginate/ Clinoptiolite Nanocomposite Hydrogel
    (Turkish Chemical Society, 2024) Sözkes, Sarkis; Taşdelen, Betül; Erdoğan, Sevil; Gülenç, Nadide Gülşah; Koruyucu, Aslıhan
    In this study, the novel nanocomposites were prepared from the natural biopolymers, chitosan (CS), sodium alginate (SA) and clinoptiolite (CL) particles, and also having glutaraldehyde as a crosslinker by cryogelation technique. CS biopolymer was produced from crayfish Astacus leptodactylus Eschscholtz, 1823. Characterization of the prepared CS, CS-co-SA (CS/SA) and drug loaded CS/SA/ CL nanocomposite were performed by Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) analyses. The anesthetic drug release behavior of the prepared nanocomposite was investigated for the model drug lidocaine (LD) using UV-Vis spectrophotometry and High Performance Liquid Chromatography (HPLC) techniques. The effect of different LD and CL content on the drug release behavior of the prepared nanocomposite were studied. LD release data was fitted to various kinetic models to study the drug release behavior. The LD release from all the prepared nanocomposite hydrogels fitted zero-order, first-order, Higuchi, and Korsmeyer-Peppas models. The swelling and drug release properties of the new CS-based nanocomposite hydrogels were improved with the inclusion of SA and CL in the gel structure. © 2024, Turkish Chemical Society. All rights reserved.
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    Radiation synthesis and characterization of chitosan/hyraluronic acid/hydroxyapatite hydrogels: drug uptake and drug delivery systems
    (Elsevier Science Bv, 2018) Taşdelen, Betül; Erdoğan, Sevil; Bekar, Bahadır
    In this work, a new chitosan (CS)/hyaluronic acid (HA)/hydroxyapatite (HAP) hydrogels were synthesized by using gamma rays irradiation technique for oral delivery of drugs. The hydrogelss were characterized using fourier transform infrared spectroscopy (FTIR) and the physicochemical properties of shrimp chitosan was determined with both FTIR and scanning electron microscopy (SEM). The use of the hydrogel samples as a drug delivery system was investigated by an anticancer drug. 5-Fluorouracil (5-FU) was used as a model anticancer drug to investigate the drug uptake and release kinetics of hydrogels. The properties of the hydrogels were evaluated in terms of swelling, drug uptake and release behaviours. The addition of hyaluronic acid and hydroxyapatite in the gel structure improved drug uptake and release capability of the new hydrogels. (c) 2018 Elsevier Ltd. All rights reserved. Selection and/or Peer-review under responsibility of 14th International Conference on Nanosciences & Nanotechnologies (NN17).