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    Varfarin Doz Aşımına Bağlı Kanamalarda Hızlı ve Etkin Bir Tedavi Yöntemi: Plazma Kompleks Konsantresi
    (Acil Tıp Uzmanları Derneği, 2020) Örün, Serhat; Şahin, Hüseyin; Erdem, Mustafa; Bıçakcı, Sercan; Başol, Batuhan; Yeniay, Elif; Demir, Mehmet
    Introduction: Warfarin is important anticoagulant that we need in indications despite. Bleeding duo to overdose of warfarin can be lifethreatening when we don’t intervene early and correctly.Case report: A 81 years old female presented with weakness, anorexia and black colored defecating. She uses warfarin for 5 years because of prosthetic heart valve. On clinical examination she had hypotension and melena. Blood tests revealed Hemoglobin: 5,14 g/dl and INR:12,08. Vitamin K, Prothrombin complex concentrate and Proton pomp inhibitor was given as treatment in emergency service. The patient hospitalised in intensive care unit for further examination and treatment. Next day blood tests revealed Hemoglobin: 8,84 g/dl and INR:3,83.  The patient with no active bleeding focus on gastroscopy and with no decrease in hemoglobin tests discharged from hospital on 2nd day of hospitalization. Low-molecular-weight heparin treatment started.Discussion: Warfarin is a drug that still needed for treatment of atrial fibrillation, mechanical heart valves, protein c-s deficiency and antiphospholipid antibody disease. Common pathology of these diseases is predisposition to embolism and thrombus formation. In the emergency services, we need to make decisions according to the patient while treating patients who have warfarin overdose bleeding.  On the one hand to stop the bleeding to ensure the patient's hemodynamics, on the other hand, the risk of thromboembolism caused by the use of warfarin should not be ignored. Therefore, it is necessary to reduce the current INR level to the targeted INR level as quickly and safely as possible.Conclusion: In conclusion, we suggest that a timely and protocol-based approach to treat coagulapathy in patients with trauma and drug-induced coagulapathy may improve patients’ prognosis.